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85 year olds who were not Vitamin D deficient had and continued to have few disabilities – Sept 2020

The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study

Nutrients 2020,12, 2742; doi:10.3390/nu12092742
Sarah Hakeem 1,2,3, Nuno Mendonca 1,2,4,5, Terry Aspray 6, , Andrew Kingston , CarmenRuiz-Martin CarolJagger John C.Mathers O/Rachel Duncan7 and Tom R.Hill 1,2' tom.hill at ncl.ac.uk
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Overview Seniors and Vitamin D
Muscle in VitaminDWiki title,
Overview Fractures and Falls and Vitamin D

Falls and Fractures category listing has 225 items along with related searches

Alzheimers-Cognition - Overview
Overview Cancer and vitamin D
Overview Influenza and vitamin D

Cancer - Prostate category listing has 95 items along with related searches

Overview Diabetes and vitamin D
Hearing Loss appears to be prevented and treated with vitamin D

Mortality category listing has 252 items along with related searches

Overview Osteoporosis and vitamin D
Restless Legs Syndrome dramatically reduced by vitamin D, etc
Overview Rheumatoid Arthritis and vitamin D
Frailty is associated with low Vitamin D many studies
Search VitaminDWIKI for "GAIT SPEED" 173 items as of Aug 2020
10 reasons why seniors need more vitamin D has the following

  1. Senior skin produces 3X less Vitamin D for the same sun intensity
  2. Seniors have fewer vitamin D receptors as they age
    • (The effect of low Vitamin D receptor genes does not show up on vitamin D test results)
  3. Seniors are indoors more than than when they were younger
    • not as agile, weaker muscles; frail, no longer enjoy hot temperatures
    • (if outside, stay in the shade), however, seniors might start outdoor activities like gardening, biking, etc.
  4. Seniors wear more clothing outdoors than when younger **+fear skin cancer/wrinkles, sometimes avoid bright light after cataract surgery
  5. Seniors often take various drugs which reduce vitamin D (some would not show up on vitamin D test) statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc
  6. Seniors often have one or more diseases which consume vitamin D ( osteoporosis, diabetes, MS, ...)
  7. Seniors generally put on weight at they age - and a heavier body requires more vitamin D
  8. Seniors often (40%) have fatty livers – which do not process vitamin D as well
  9. Seniors not have as much Magnesium needed to use vitamin D
    (would not show up on vitamin D test)
  10. Seniors with poorly functioning kidneys do not process vitamin D as well
    (would not show up on vitamin D test) 2009 full text online  Also PDF 2009
  11. Vitamin D is not as bioavailable in senior digestive systems (Stomach acid or intestines?)

 Download the PDF from VitaminDWiki
Model 4
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Background: Low vitamin D status is common in very old adults which may have adverse consequences for muscle function, a major predictor of disability. Aims: To explore the association between 25-hydroxyvitamin D [25(OH)D] concentrations and disability trajectories in very old adults and to determine whether there is an ‘adequate' 25(OH)D concentration which might protect against a faster disability trajectory.

Methodology: A total of 775 participants from the Newcastle 85+ Study for who 25(OH)D concentration at baseline was available. Serum 25(OH)D concentrations of <25 nmol/L, 25-50 nmol/L and >50 nmol/L were used as cut-offs to define low, moderate and high vitamin D status, respectively. Disability was defined as difficulty in performing 17 activities of daily living, at baseline, after 18,36 and 60 months.

Results: A three-trajectory model was derived (low-to-mild, mild-to-moderate and moderate-to-severe). In partially adjusted models, participants with 25(OH)D concentrations <25 nmol/L were more likely to have moderate and severe disability trajectories, even after adjusting for sex, living in an institution, season, cognitive status, BMI and vitamin D supplement use. However, this association disappeared after further adjustment for physical activity. Conclusions: Vitamin D status does not appear to influence the trajectories of disability in very old adults.

Attached files

ID Name Comment Uploaded Size Downloads
14635 disability 3 curves.jpg admin 29 Nov, 2020 18:05 47.65 Kb 128
14634 Trajectory model 4.jpg admin 29 Nov, 2020 18:01 44.17 Kb 109
14633 Disability Trajectories.pdf PDF 2020 admin 29 Nov, 2020 18:01 747.84 Kb 93
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