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Migraine headaches reduced with 50,000 IU vitamin D weekly – RCT July 2015

Effect of Vitamin D supplementation on symptoms and C-reactive protein in migraine patients

Journal of Research in Medical Sciences
Tayebeh Mottaghi, Gholamreza Askari, Fariborz Khorvash, Mohammad Reza Maracy

Background: Migarine is the most common headache around the world including Iran. In recent years, Vitamin D deficiency has been shown to a global health problem. A few studies have been determined inverse association between serum levels of Vitamin D with a headache. So, in this study, we investigated the effect of Vitamin D supplementation on symptoms and C-reactive protein(CRP) among patients with migraine.

Materials and Methods: This study was randomized, double-blind, and controlled-placebo clinical trial. Sixty-five migraine patients aged 10-61 years were included for analysis. Vitamin D was administrated for 10 weeks with 50,000 IU dosage of Vitamin D per week. Multivariate analysis of covariate and univariate analysis of covariate were done to determine the effects of Vitamin D supplementation on symptoms, including severity, duration, frequency of headache, and the headache diary result (HDR).

Results: Mean headache frequency and HDR had significant difference among two groups (5.9 ± 7.0 vs. 7.0 ± 6.0, P = 0.06 and 85.0 ± 134.2 vs. 132.1 ± 147.1, P = 0.04). But, a mean difference of headache frequency was marginally significant (P = 0.06). These values were lower among the intervention group compared to placebo group. The association was not observed between CRP with migraine disease.

Conclusion: In this study, we shown Vitamin D supplementation may be useful in decreasing frequency of headache attacks and HDR among patients with migraine.

See also VitaminDWiki

Headaches helped by Vitamin D in 7 studies – Jan 2020
Pages listed in BOTH the categories Headache and Magnesium

  • Headache category listing has 43 items along with related searches which has the following

Migraine Headaches associated with metal excess/deficiencies - July 2015
Compared blood levels of 25 with migraines to 25 without

Metal MigraineNo Migraine Ratio
Cadmium 0.36 ug0.09 ug 4X MORE
Iron0.97 ug0.48 ug2X MORE
Lead1.48 ug0.78 ug 2X MORE
Magnesium10.6 ug34.5 ug 3.5X LESS
Zinc0.24 ug 5.77 ug 24X LESS

Speculation by VitaminDWiki
Significant migraine reduction if use 10,000 IU of vitamin D, Magnesium, and perhaps Zinc

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