Serum ‘Vitamin-Mineral’ Profiles: Associations with Postmenopausal Breast Cancer Risk Including Dietary Patterns and Supplementation. A Case-Control Study
Nutrients 2019, 11(9), 2244; https://doi.org/10.3390/nu11092244
- Review of Breast cancer prevention by Vitamin D, and other micronutrients– June 2019
- Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019
- Breast Cancer and Vitamin D review – March 2018
- Women worried about breast cancer seem to be taking vitamin D – Jan 2019
- Safer Than Mammograms, Slashes Your Risk by 83 Percent – Vitamin D, Mercola – Oct 2018
- Breast Cancer prevented by Vitamin D (most studies concur) – Dec 2017
- Breast Cancer rate reduced by 40 percent with Omega-3 – meta-analysis June 2013
- Mortality increased: 4X Cancer, 5X Diabetes if eat a lot of meat protein – March 2014
Overview Breast Cancer and Vitamin D contains the following summary and sections
-
25 Meta-analyses of Vitamin D and Breast Cancer
example: 2X reduction of deaths from Breast Cancer if have enough Vitamin D.- Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer
wonder just how much more proof is needed- Breast Cancer 4X more likely if have poor genes
- Cancer - Breast category listing has
256 items along with related searches - Breast Cancer treatment – Vitamin D was the most-popular supplement – Jan 2023
- Breast Cancer again associated with low vitamin D – 15th meta-analysis Sept 2020
- Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019
- Vitamin D both prevents and treats Breast Cancer – 2019
Breast Cancer incidence also depends on VItamin D Genes
- Breast Cancer incidence change by 40 percent with vitamin D receptor genes – Oct 2012
- Women with Breast Cancer were 16.9 times more likely to have a poor Vitamin D Receptor – Jan 2019
 Download the PDF from VitaminDWiki
Beata Krusinska 1,*,Lidia Wadolowska ,Maciej Biernacki 2,Malgorzata Anna Slowinska 1 and Marek Drozdowski 3
1 Department of Human Nutrition, University of Warmia and Mazury in Olsztyn, Sloneczna 45f, 10-718 Olsztyn, Poland
2 Department of Surgery, University of Warmia and Mazury in Olsztyn, 11-041 Olsztyn, Poland
3 Department of Laboratory Medicine, University of Warmia and Mazury in Olsztyn, 11-041 Olsztyn, PolandBreast cancer is the most prevalent cancer in females worldwide. Studies evaluating the blood vitamins and minerals status in the breast cancer etiology are limited, and the results are inconclusive. This study analyzed the association between serum vitamin-mineral profiles (V-MPs) and breast cancer (BC) risk with including dietary patterns (DPs) and the use of supplements. This case-control study involved 420 women aged 40–79 years from north-eastern Poland, including 190 newly diagnosed breast cancer cases. The fasting serum concentrations of vitamins (folate, cobalamin, 25(OH) vitamin D) and minerals (iron, calcium, magnesium) were measured in 129 post-menopausal women, including 82 controls and 47 cases. Three V-MPs were derived with a Principal Component Analysis (PCA). A logistic regression analysis was performed to estimate the odds ratio (OR) and 95% confidence interval (95% CI) of the breast cancer risk associated with serum V-MPs and serum levels of single biomarkers. The risk of BC was lower by 88% (OR: 0.12; 95% Cl: 0.02–0.88; p < 0.05) in the upper tertile of the serum ‘Iron-Calcium’ profile compared to the bottom tertile, lower by 67% (OR: 0.33; 95% Cl: 0.11–0.97; p < 0.05) at the level of serum 25(OH) vitamin D ≥24.6 ng/mL and lower by 68% (OR: 0.32; 95% Cl: 0.11–0.91; p < 0.05) at the level of serum calcium ≥9.6 mg/dL. There was an inverse association of the serum ‘Magnesium’ profile or serum level of iron with the risk of BC, which disappeared after adjustment for the set of confounders accounted for: age, body mass index (BMI), socioeconomic status, overall physical activity, smoking status, age at menarche, number of full-term pregnancies, oral contraceptive use, hormone-replacement therapy use, family history of breast cancer, vitamin/mineral supplement use, the molecular subtype of breast cancer, and dietary patterns. No significant association was found between BC risk and the serum ‘Folate-Cobalamin-Vitamin D’ profile or serum folate, cobalamin or magnesium considered separately. These findings highlight that a higher-normal serum level of both iron and calcium, considered together as the serum profile, as well as a higher-normal serum level of calcium, considered separately, and a slightly below the normal range of serum vitamin D level may protect against breast cancer among postmenopausal women, independent of dietary patterns or the use of vitamin/mineral supplements. Therefore, the maintenance of the adequate status of vitamins and minerals and the regular monitoring of their blood markers should be included in breast cancer prevention.
Breast Cancer 3X more likely if low vitamin D (Principal Component Analysis) – Sept 20194845 visitors, last modified 18 Sep, 2019, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 12656 Breast Cancer PCA.jpg admin 18 Sep, 2019 81.84 Kb 597 12655 Breast Cancer Vitamin Mineral PCA.pdf admin 18 Sep, 2019 431.42 Kb 535 - Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer