Am J Epidemiol. 2019 Jan 4. doi: 10.1093/aje/kwy285.
O'Brien KM1,2, Sandler DP1, House M3, Taylor JA1, Weinberg CR2.
1 Epidemiology Branch, National Institutes of Environmental Health Sciences.
2 Biostatistics and Computational Biology Branch, National Institute of Enviro, Health Sciences.
3 Westat, Inc., Durham, NC.
- The women had sisters who had gotten breast cancer and were in a study analyzing the association between Vitamin D and breast cancer
- Vitamin D Test #1, They did/did not get Breast Cancer, Vitamin D Test #2
|Test #1||Test #2 |
4-10 years later)
|Breast Cancer risk|
per +10 ng of Vit D
|No Breast Cancer||32 ng||40 ng||-13%|
|Breast Cancer||32 ng||44 ng||+17%|
Note: Increasing Vitamin D for just a few years does not decrease the chance of breast cancer,
but will increase survival
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
- Vitamin D and breast cancer radiation
- Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
- Vitamin D reduces the risk of Breast Cancer, improves treatment, and improves survival
- Breast Cancer treatment outcome might be predictable from Vitamin D test results – trial 2024
Genes can restrict how much Vitamin D acually gets to tissues (Breast Cancer Cells)
- Breast Cancer incidence change by 40 percent with vitamin D receptor genes – Oct 2012
- Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018
- Breast Cancer was 4.6 times more likely if have a poor Vitamin D Receptor – Dec 2016
- Increased Breast Cancer metastasis if low vitamin D or poor VDR – Feb 2016
- Note: Resveratrol etc, increases how much vitamin D actually gets to cells
A strategy of Breast Cancer cells is to decrease Vitamin D it gets
contains the following
- 16+ meta-analyses of Vitamin D and Breast Cancer
example: 2X reduction of deaths from Breast Cancer if have enough Vitamin D.
- Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer
wonder just how much more proof is needed
- Breast Cancer 4X more likely if have poor genes
- Cancer - Breast category listing has
220 items along with related searches
Prospective and retrospective studies of vitamin D and breast cancer have produced discrepant results. This may be due to variations in serum 25-hydroxyvitamin D [25(OH)D] concentrations over time, including systematic changes after breast cancer diagnosis. We measured total serum 25(OH)D in Sister Study participants who provided samples at baseline (2003-2009) and 4-10 years later (2013-2015). This included 827 women with an intervening breast cancer and 771 without. Although modestly correlated over time (R=0.42), 25(OH)D concentrations increased in both groups, with larger increases among cases (averaging 31.6 ng/mL at baseline, 43.5 ng/mL at follow-up) than controls (32.3 ng/mL at baseline, 40.4 ng/mL at follow-up). Consequently, the estimated association between 25(OH)D and breast cancer depended on whether baseline (odds ratio [OR]=0.87, 95% confidence interval [CI]: 0.78-0.98 per 10 ng/mL) or second blood draw measures (OR=1.17, 95% CI: 1.08-1.26 per 10 ng/mL) were used.
Concentrations were related to regular (>4 times/week) vitamin D supplement use, which became more common over time. Increases were greater in cases (56% to 84%) than in controls (56% to 77%).
Our results do not explain previously observed differences between retrospective and prospective studies, but do demonstrate how reverse causation and temporal trends in exposure can distort inference.