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Fertil Steril . 2023 Dec 23:S0015-0282(23)02094-0. doi: 10.1016/j.fertnstert.2023.12.023. Online ahead of print.
Association between Serum 25-hydroxyvitamin D and Antimüllerian Hormone in a Cohort of African-American Women
Anita Subramanian 1, Quaker E Harmon 2, Lia A Bernardi 3, Mercedes R Carnethon 4, Erica E Marsh 5, Donna D Baird 2, Anne Marie Z Jukic 2
Affiliations expand
PMID: 38145700 DOI: 10.1016/j.fertnstert.2023.12.023
Abstract
Objective: To examine the association between serum 25-hydroxyvitamin D [25(OH)D] and ovarian reserve as measured by antimüllerian hormone (AMH).
Design: Cross-sectional study.
Setting: Detroit, Michigan area.
Subjects: Data were obtained from a prospective cohort of self-identified Black/African-American women aged 23-35 years at the time of enrollment (N=1593), had no prior diagnosis of polycystic ovary syndrome (PCOS), were not currently pregnant, and were not missing AMH or 25(OH)D measures.
Exposure: Serum 25(OH)D.
Main outcome measure: Serum AMH was the main outcome. Linear regression was used to examine the associations between categorical 25(OH)D (<12 ng/mL, 12-<20, 20-<30, ≥30) and continuous natural log-transformed AMH. Associations between 25(OH)D and high (upper 10th percentile: >7.8 ng/mL) or low AMH (<0.7 ng/mL) were estimated with logistic regression. Models were adjusted for age, age-squared, BMI, hormonal contraceptive use, smoking, and exercise.
Results: The 25(OH)D levels were low; 70% of participants were below 20 ng/mL. In fully-adjusted models, compared to 25(OH)D levels <12 ng/mL, those with 25(OH)D levels of 12-<20, 20-<30 and ≥30 ng/mL had an AMH level that was 7% (95% CI: -4, 20) , 7% (95% CI: -6, 22), or 11% higher (95% CI: -7, 34), respectively. Moreover, these groups had a lower odds of having low AMH (OR[95% CI): 0.63 (0.40, 0.99), 0.60 (0.34, 1.07), 0.76 (0.35, 1.65), respectively, and the highest category of 25(OH)D had a higher odds of having high AMH, (OR [[95% CI]: 1.42 [0.74, 2.72]). Exclusion of participants with either irregular cycles or very high AMH (>25 ng/mL), did not alter the associations.
Conclusion: Taken together, these results indicate that higher levels of 25(OH)D are associated with a slightly higher AMH, a lower odds of low AMH, and a higher odds of high AMH. This evidence is weak, however, since only a small percentage of participants had high 25(OH)D. Future studies should examine populations with a wide distribution of 25(OH)D levels (both high and low), with a clinical trial design, or with longitudinal measures of both 25(OH)D and AMH.
VitaminDwiki – Fertility and Sperm category contains
See also:
Overview Women and Vitamin D
Overview Pregnancy and vitamin D Fertility and Vitamin D – several articles
Endometriosis
Ensure a healthy pregnancy and baby - take Vitamin D before conception
IVF OR "IN VITRO FERTILIZATION" etc. in 18 VitaminDWiki titles
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- Vitamin D is needed for human fertility – goal is 50 ng – Sept 2018
- In-vitro Fertilization costs at least 10,000 dollars, Vitamin D costs 5 dollars
- Women were 50X more likely to be fertile if just 1 ng higher level of vitamin D – Nov 2024
- Infertile patients 1.7X more-likely to become pregnant if take Vitamin D – meta-analysis Feb 2023
- Live birth 1.7 X more likely after IVF if good level of vitamin D – meta-analysis Aug 2020
- If diagnosed infertile, more likely to have live birth if Vitamin D fortification – Feb 2020
- Preconception vitamin D is great - every extra 10 ng associated with 10 percent more likely to have live birth – Aug 2018
- Women with more than minimum vitamin D were 3.4 X more likely to achieve pregnancy and 1.6 X more likely to have live births – June 2017
- Assisted Reproduction – 5 studies concluded vitamin D repletion helps – Review March 2015
- Pregnancy success increased 30 percent if sunny (or vitamin D) one month earlier – June 2015
- IVF 4X more successful for white women with lots of vitamin D – many studies
Increased male Vitamin D increases fertility
- Birth rates doubled with Vitamin D - 300,000 for infertile men – RCT Nov 2017
- Higher vitamin D results in 22% fewer abnormal sperm (Mendelian analysis) – May 2024
- Conception was 3.7X more likely if the male had a good level of Vitamin D – July 2022
- Far better sperm in fertility clinic if more than 30 ng of Vitamin D - June 2022
- Fertility (sperm) associated with vitamin D – meta-analysis Sept 2019
- Infertility - 71 percent of the time of BOTH partners had less than 20 ng of Vitamin D – Aug 2017
- Male fertility 4 X higher if high Vitamin D – Nov 2015
- Vitamin D somewhat assists reproduction – both the mother and the father – May 2014
Decreased Fertility if decreased Vitamin D Receptor
- Unexplained infertility 4X more likely if poor vitamin D receptor – Dec 2020
- Male Infertility is associated with poor Vitamin D Receptor – July 2021
Observational Study PLoS One
. 2023 Dec 22;18(12):e0292780. doi: 10.1371/journal.pone.0292780. FREE PDF
Effects of medical and surgical treatment on vitamin D levels in obesity
Ala Mejaddam 1 2, Gudrún Höskuldsdóttir 2 3, Frida Lenér 2 4, Ville Wallenius 5, Penelope Trimpou 2 3, Lars Fändriks 5, Karin Mossberg 2 4, Björn Eliasson 3, Kerstin Landin-Wilhelmsen 2 3
Affiliations expand
PMID: 38134006 PMCID: PMC10745143 DOI: 10.1371/journal.pone.0292780
Free PMC article
Abstract
Introduction: Persons living with obesity treated with bariatric surgery are at a high risk of developing nutritional deficiencies. The primary aim of this observational cohort study was to compare vitamin D levels in patients two years after bariatric surgery (Roux-en-Y gastric bypass/RYGB and sleeve gastrectomy/SG) with a very low-energy diet (VLED). The same subjects were also compared with a population sample from the same region at baseline. The primary hypothesis was that surgery, especially RYGB, would lead to an increased prevalence of vitamin D deficiency compared to subjects treated with VLED. 971 individuals eligible for surgical, RYGB (n = 388), SG (n = 201), and medical treatment (n = 382), in routine care, were included consecutively between 2015 and 2017. A random population sample from the WHO-MONICA project was used as a reference, (n = 414). S-calcium, S-25(OH)D (vitamin D), and S-PTH (parathyroid hormone) were measured in all persons with obesity at baseline and two years after treatment (n = 713). Self-reported use of vitamin D and calcium supplementation was registered.
Results: Vitamin D deficiency (S-25(OH)D <25mmol/l) was found in 5.2% of the persons with obesity at baseline versus 1.7% of the general population (SMD>0.1). S-25(OH)D increased for all treatment groups but was higher in RYGB and SG (SMD>0.1, standardized mean difference). Thirteen subjects (1.8%) had vitamin D deficiency after obesity treatment.
Conclusion: Surgical intervention for obesity followed by vitamin D supplementation was not associated with a higher risk for vitamin D deficiency, irrespective of surgery type, compared to individuals on medical treatment. However, persons living with obesity seeking weight loss treatment are more likely to have deficient vitamin D levels compared to the general population.
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