Is There Any Association Between Thrombosis and Tissue Factor Pathway Inhibitor Levels in Patients With Vitamin D Deficiency?
CLIN APPL THROMB HEMOST November 6, 2013 1076029613509477
Oya Topaloglu, MD oyasude at gmail.com
Muyesser Sayki Arslan, MD
Melia Karakose, MD
Bekir Ucan, MD
Evrim Cakir, MD
Esra Tutal Akkaymak, MD
Mustafa Sahin, MD
Mustafa Ozbek, MD
Erman Cakal, MD
Tuncay Delibasi, MD
Objective: The aim of this study was to evaluate the relationship between vitamin D levels and hemostatic factors like tissue factor pathway inhibitor (TFPI).
Methods: Patients who had 25-hydroxyvitamin D3 (25(OH)D3) levels measured were included.
Coagulation and hemostatic parameters were evaluated.
Patients were divided into 3 groups based on 25(OH)D3 levels as
- group 1 (25(OH)D3 < 10 ng/mL, n = 25),
- group 2 (25(OH)D3 = 10-19.9 ng/mL, n = 22), and
- group 3 (25(OH)D3 ≥ 20 ng/mL, n = 28).
Results: A total of 75 patients with a mean age of 39 (range 18-57) years were included in the study.
Prothrombin time was longer in group 3 than in group 2 (P = .043).
The TFPI levels were higher in group 3 than in the other groups (P < .001).
There was a strong positive correlation between 25(OH)D3 and TFPI levels (r = .47, P < .001).
Conclusion: Further studies are needed for evaluation of the role of TFPI in hemostasis and thrombotic process in patients with vitamin D deficiency.
WikiPedia Nov 2013
Thrombosis (Greek: θρόμβωσις) is the formation of a blood clot (thrombus; Greek: θρόμβος) inside a blood vessel, obstructing the flow of blood through the circulatory system. When a blood vessel is injured, the body uses platelets (thrombocytes) and fibrin to form a blood clot to prevent blood loss. Even when a blood vessel is not injured, blood clots may form in the body under certain conditions. A clot that breaks free and begins to travel around the body is known as an embolus.