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Kidney not essential for Vitamin D3 activation – fungi can do it – Jan 2014

Microbial production of 1α-hydroxyvitamin D3 from vitamin D3.

Nat Prod Res. 2014 Jan 23.
Ahmed SA, Mesbah MK, Youssef DT, Khalifa SI.
Department of Pharmacognosy , Faculty of Pharmacy, Suez Canal University , Ismailia , Egypt.

The microbial transformation of vitamin D3 (1) by the fungi Candida maltosa R42 and Botrytis allii NRRL 2502 was investigated. Incubation of compound 1 with C. maltosa R42 and B. allii NRRL 2502 produced the same three more polar metabolites in small yields. The main metabolite was identified as 1α-hydroxyvitamin D3 (2). This biotransformation has utility as a possible tool for the production of 1α-hydroxyvitamin D3 from the readily available vitamin D3 for patients with compromised kidney function.

PMID: 24456427 Publisher charges $46 for the PDF


See also VitaminDWiki

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