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Vitamin D: A Potential Star for Treating Chronic Pancreatitis – June 2022


Vitamin D: A Potential Star for Treating Chronic Pancreatitis

Front Pharmacol. 2022 Jun 6;13:902639. doi: 10.3389/fphar.2022.902639. eCollection 2022.
Meifang Zheng 1, Runping Gao 1

Chronic Pancreatitis studies

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Chronic Pancreatitis Clinical Trials

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Chronic pancreatitis (CP) is a chronic inflammatory and fibrotic disease of the pancreas. The incidence of CP is increasing worldwide but the effective therapies are lacking. Hence, it is necessary to identify economical and effective agents for the treatment of CP patients. Vitamin D (VD) and its analogues have been confirmed as pleiotropic regulators of cell proliferation, apoptosis, differentiation and autophagy. Clinical studies show that VD deficiency is prevalent in CP patients. However, the correlation between VD level and the risk of CP remains controversial. VD and its analogues have been demonstrated to inhibit pancreatic fibrosis by suppressing the activation of pancreatic stellate cells and the production of extracellular matrix. Limited clinical trials have shown that the supplement of VD can improve VD deficiency in patients with CP, suggesting a potential therapeutic value of VD in CP. However, the mechanisms by which VD and its analogues inhibit pancreatic fibrosis have not been fully elucidated. We are reviewing the current literature concerning the risk factors for developing CP, prevalence of VD deficiency in CP, mechanisms of VD action in PSC-mediated fibrogenesis during the development of CP and potential therapeutic applications of VD and its analogues in the treatment of CP.
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Some Pancreatitis and Vitamin D studies on the web

  • Vitamin D and Pancreatitis: A Narrative Review of Current Evidence- May 2022 PDF
  • Nutritional management of chronic pancreatitis: A systematic review and meta-analysis of randomized controlled trials - Jan 2021 PDF
  • Vitamin D deficiency predicts severe acute pancreatitis - Oct 2018 PDF

VitaminDWiki Inflammation pages with PANCREATITIS in title (6 as of June 2022)

This list is automatically updated

Items found: 7

VitaminDWiki - Inflammation category contains

151 items total

Example studies

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Vitamin C also helps CP

Comment by Dave M. Both vitamin D and C are depleted in patients with severe pancreatitis. Vitamin C deficiency increases the likelihood of fibrosis which markedly worsen the observed outcomes. Vitamin D may improve vitamin C status via the increase in levels of glutathione- this may partially account for improvements when vitamin D is used alone... but one can only imagine the benefits of measuring and correcting both D and C deficiencies simultaneously.


Created by admin. Last Modification: Monday June 27, 2022 14:51:24 GMT-0000 by admin. (Version 14)

Attached files

ID Name Comment Uploaded Size Downloads
17956 Vit C chronic pancreatitis_CompressPdf.pdf admin 23 Jun, 2022 20:45 235.87 Kb 5
17953 CP Meta_CompressPdf.pdf admin 23 Jun, 2022 15:34 311.49 Kb 4
17952 P current evidence_CompressPdf.pdf admin 23 Jun, 2022 15:34 280.04 Kb 6
17951 Predicts P.pdf admin 23 Jun, 2022 15:34 254.23 Kb 6
17950 Vitamin D - A Potential Star for Treating Chronic Pancreatitis_CompressPdf.pdf PDF 2022 admin 23 Jun, 2022 15:11 799.25 Kb 5
17949 CP Clinical trials.jpg admin 23 Jun, 2022 15:10 66.73 Kb 31
17948 CP Studies.jpg admin 23 Jun, 2022 15:10 134.38 Kb 41
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