Vitamin D: A Potential Star for Treating Chronic Pancreatitis
Front Pharmacol. 2022 Jun 6;13:902639. doi: 10.3389/fphar.2022.902639. eCollection 2022.
Meifang Zheng 1, Runping Gao 1
Chronic Pancreatitis studies
Chronic Pancreatitis Clinical Trials
Chronic pancreatitis (CP) is a chronic inflammatory and fibrotic disease of the pancreas. The incidence of CP is increasing worldwide but the effective therapies are lacking. Hence, it is necessary to identify economical and effective agents for the treatment of CP patients. Vitamin D (VD) and its analogues have been confirmed as pleiotropic regulators of cell proliferation, apoptosis, differentiation and autophagy. Clinical studies show that VD deficiency is prevalent in CP patients. However, the correlation between VD level and the risk of CP remains controversial. VD and its analogues have been demonstrated to inhibit pancreatic fibrosis by suppressing the activation of pancreatic stellate cells and the production of extracellular matrix. Limited clinical trials have shown that the supplement of VD can improve VD deficiency in patients with CP, suggesting a potential therapeutic value of VD in CP. However, the mechanisms by which VD and its analogues inhibit pancreatic fibrosis have not been fully elucidated. We are reviewing the current literature concerning the risk factors for developing CP, prevalence of VD deficiency in CP, mechanisms of VD action in PSC-mediated fibrogenesis during the development of CP and potential therapeutic applications of VD and its analogues in the treatment of CP.
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Some Pancreatitis and Vitamin D studies on the web
- Vitamin D and Pancreatitis: A Narrative Review of Current Evidence- May 2022 PDF
- Nutritional management of chronic pancreatitis: A systematic review and meta-analysis of randomized controlled trials - Jan 2021 PDF
- Vitamin D deficiency predicts severe acute pancreatitis - Oct 2018 PDF
VitaminDWiki Inflammation pages with PANCREATITIS in title (6 as of June 2022)
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VitaminDWiki - Inflammation category contains
Example studies
- Vitamin D energizes the innate and adaptive immune systems to fight lung inflammation – Sept 2022
- COVID-19 inflammation extinguished by 60,000 IU of vitamin D nanoemulsion daily for a week – RCT May 2021
- Inflammation (C-reactive protein) associated with low vitamin D in 22 diseases – April 2020
- Vitamin D reduces inflammation in critically ill patients – Sept 2020
- Inflammation is reduced by each of the following: Vitamin D, Omega-3, Diet
- How Vitamin D reduces inflammation, improves immunity and fights autoimmunity – review Dec 2018
- CYTOKINE in VitaminDWiki 12 titles as of July 2023
- 17 pages in VitaminDWiki had REACTIVE or CRP in title as of July 2023
- Little risk of infection after surgery if have more than 50 ng of vitamin D - 2014
Vitamin C also helps CP
Comment by Dave M. Both vitamin D and C are depleted in patients with severe pancreatitis. Vitamin C deficiency increases the likelihood of fibrosis which markedly worsen the observed outcomes. Vitamin D may improve vitamin C status via the increase in levels of glutathione- this may partially account for improvements when vitamin D is used alone... but one can only imagine the benefits of measuring and correcting both D and C deficiencies simultaneously.
- Vitamin C status in patients with acute pancreatitis - 1993 https://doi.org/10.1002/bjs.1800800632
- Systematic review and meta-analysis: Is there any role for antioxidant therapy for pain in chronic pancreatitis - Oct 2020 PDF
- Vitamin C intake and multiple health outcomes: an umbrella review of systematic reviews and meta-analyses - March 2022 https://doi.org/10.1080/09637486.2022.2048359
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