Loading...
 
Translate Register Log In Login with facebookLogin and Register

Testing misses the Vitamin D tied up with VDBP – June 2014

Assessing Vitamin D Status: Time for a Rethink?

Clinical Chemistry, June 2014 vol. 60 no. 6 809-811
Graham D. Carter1,* and Karen W. Phinney2
1 Imperial College Healthcare NHS Trust, Oncology/Endocrine Laboratory, Charing Cross Hospital, London, UK;
2 Biomolecular Measurement Division, NIST, Gaithersburg, MD
↵* Address correspondence to this author at: Imperial College Healthcare NHS Trust, Oncology/Endocrine Laboratory Charing Cross Hospital, Fulham Palace Rd., London W6 8RF, UK. Fax +44-(0)20-8846-7007; e-mail b.carter1 at which.net.

The first 20% of the full text of this article appears below.
Vitamin D status is universally assessed by measuring circulating total 25-hydroxyvitamin D [25(OH)D]3, the sum of 25(OH)D3 and 25(OH)D2. However, despite the widespread acceptance of this biomarker of vitamin D status, studies have suggested that measurement of 25(OH)D alone may not be sufficient to understand the relationship between vitamin D exposure and certain health outcomes. As a result, attention has turned to other aspects of vitamin D biology.

Approximately 90%–95% of 25(OH)D is tightly bound to a specific α globulin, vitamin D binding protein (VDBP), which is structurally related to serum albumin. Of the remaining 25(OH)D, about 1% is unbound and the rest loosely bound to serum albumin.

A current hypothesis is that the free and albumin-bound moieties are responsible for delivering 25(OH)D to the cell, with the VDBP-bound 25(OH)D acting as a reservoir of the metabolite.

In humans, common genetic polymorphisms produce 3 major circulating variants of the VDBP (Gc1F, Gc2, and Gc1S), which differ in their affinity for 25(OH)D. The prevalence of these polymorphs has been shown to vary across different ethnicities and populations, with the Gc1F variant generally more common among individuals of African ancestry. In a recent study reported in the New England Journal of Medicine (1), Powe et al. investigated the prevalence of the different VDBP phenotypes (Gc1F, Gc2, and Gc1S) in a cohort of black and white Americans and examined the relationship with 25(OH)D concentrations as well as other parameters. Unlike previous investigations, this study included measurements of the concentration of serum VDBP. In this work, black Americans were found to have a preponderance of the high-affinity Gc1F phenotype, with homozygotes having about half the concentration of total VDBP found in whites, in whom the Gc1S variant predominated. The mean concentration of total 25(OH)D was also lower in blacks …


20 Most-visited pages in VDBP category in VitaminDWiki__

Id Page Hits Last modification Creator Categories
3439 Genetics 35804
07 Oct, 2019 16:20
ricks99 Genetics
Vitamin D Receptor
Vit D Binding Protein
Category
6867 Vitamin D Binding Protein 19333
15 Oct, 2019 22:23
admin Vit D Binding Protein
Category
7403 Health problems that run in families are often associated with low vitamin D 11820
13 Feb, 2018 23:52
admin Health
Genetics
Top news
Vitamin D Receptor
Vit D Binding Protein
3881 Vitamin D level can be high, but little benefit: due to kidney, genes, low Magnesium etc. 9629
28 Nov, 2014 19:11
admin Deficiency of Vitamin D
How much Vitamin D
Kidney
Vitamin D and Magnesium
Genetics
Top news
Vitamin D Receptor
Vit D Binding Protein
6306 Growth Hormone problem (Acromegaly) more likely if vitamin D gene problems 8229
18 Mar, 2019 21:09
admin Vitamin D Receptor
Vit D Binding Protein
6835 Genes make Multiple Sclerosis 2X more likely unless get more vitamin D - Aug 2015 6540
22 Sep, 2015 12:29
admin Multiple Sclerosis
Genetics
Top news
Vit D Binding Protein
3672 GC, CYP2R1 and DHCR7 genes associated with low vitamin D levels in China – 2012, 2013 6388
18 Apr, 2018 21:59
admin Genetics
Vit D Binding Protein
Orient
4011 Common Vitamin D gene variants and resulting diseases – Jan 2013 5390
16 Oct, 2017 11:16
admin Genetics
Top news
Vit D Binding Protein
208 How vitamin D helps the lung via vitamin D-binding protein - May 2010 5265
22 Oct, 2017 20:33
admin Breathing
Technical D
Genetics
Vit D Binding Protein
6797 Bioavailable Vitamin D is the same blacks and whites, but measured vit D is not – Oct 2014 5251
31 Dec, 2015 13:53
admin Skin - Dark
Vit D Binding Protein
5703 Tuberculosis, Genes, Vitamin D Binding Protein, and RCT – Review Aug 2014 5201
24 Aug, 2014 12:31
admin Tuberculosis
Genetics
Vit D Binding Protein
1286 Type 1 diabetes patients may be pissing away vitamin D – Jan 2011 5133
14 May, 2014 18:56
admin Diabetes
Vit D Binding Protein
5556 4700 IU of vitamin D needed by most seniors – an equation -July 2014 4951
19 Jan, 2015 16:00
admin How much Vitamin D
Seniors
Predict Vitamin D
Vit D Binding Protein
8113 Vitamin D - Binding Protein, Receptor, enzymes and health benefits - review Jan 2016 4662
15 Apr, 2017 20:19
admin Genetics
Vitamin D Receptor
Vit D Binding Protein
6016 Gene makes COPD 2.6X more likely unless get more vitamin D – meta-analysis Dec 2014 4636
04 Nov, 2015 18:49
admin Breathing
Meta-analysis of Vitamin D
Vit D Binding Protein
6158 Multiple Sclerosis is associated with about 1.5 X more Vitamin D Binding Protein – Jan 2015 4566
25 Feb, 2015 22:44
admin Multiple Sclerosis
Vit D Binding Protein
3383 Heart problems such as Afib related to little Magnesium, Omega-3, Vitamin D getting to tissues 4463
19 Aug, 2019 15:54
admin Cardiovascular
Vitamin D and Magnesium
Vitamin D and Omega-3
Vit D Binding Protein
6881 Alzheimer’s Disease is associated with genes which restrict vitamin D – Aug 2015 4447
18 Sep, 2018 09:10
admin Cognitive
Vitamin D Receptor
Vit D Binding Protein
1979 Vitamin D and Chronic Kidney Disease – Aug 2011 4295
29 May, 2014 16:34
admin Kidney
Vit D Binding Protein
5534 Role of Vitamin D in human Diseases and Disorders – An Overview – DBP, VDR June 2014 4170
04 Aug, 2015 22:46
admin Cancer
Genetics
Vitamin D Receptor
Vit D Binding Protein
See any problem with this page? Report it (FINALLY WORKS)