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Role of Vitamin D in human Diseases and Disorders – An Overview – DBP, VDR June 2014

International Journal of Pharmacological Research, Vol 4, No 2 (2014)
Priyanshee Gohil, Palak Solanki
Priyanshee Gohil, Assistant Professor, K.B.Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat, India
Palak Solanki. Department of Pharmacology and Clinical Pharmacy, K. B. Instituteof Pharmaceutical Education & Research, Kadi SarvaVishvavidyalya, Gandhinagar. India

Vitamin D is a fat soluble vitamin and generated in human skin by ultraviolet (UV) light. Today, vitamin D is considered to be a steroidal hormone and plays a central role in bone mineralization and calcium homeostasis. The active form of the vitamin D is 1, 25-dihydroxyvitamin D [1, 25-dihydroxycholecalciferol (DHCC)] which mediates proliferation, differentiation and various functions at the cellular level through Vitamin D receptors (VDR).Therefore, compromised vitamin D status is likely to be involved in progression or pathogenesis of various disorders. This assumption is consistent with findings from epidemiological studies that a compromised vitamin D status in humans increases the risk of autoimmune diseases, such as inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus (SLE), multiple sclerosis and type I diabetes mellitus. However, diseases like cancer, cardiovascular disorders and bone disorders are yet not focused. Thus the role of vitamin D in pathogenesis of various diseases is complex and controversial. This review briefly summarizes the role of vitamin D in development and progression of different human disorders.

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Role of Vitamin D in human Diseases and Disorders – An Overview – DBP, VDR June 2014

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- Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014 Overview Leukemia and Vitamin D Intense exercise increases vitamin D receptor activation Health problems that run in families are often associated with low vitamin D Genes are one of the reasons for low response to vitamin D – Nov 2014 Vitamin D-binding protein controls T cell responses to vitamin D in the lab – Sept 2014 Thin epidermis under skin cancer was thickened when vitamin D was raised to 70 ng – April 2014 Gene makes COPD 2.6X more likely unless get more vitamin D – meta-analysis Dec 2014 Vitamin D Binding Protein special Issue – June 2014 Vitamin D Receptors are important for health (technical)– May 2015

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Cancer 268 Genetics 336 Vitamin D Receptor 525 Vit D Binding Protein 174

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