Correction of vitamin D deficiency improves seizure control in epilepsy: A pilot study
Epilepsy & Behavior; Available online 11 April 2012
Brief Communication http://dx.doi.org/10.1016/j.yebeh.2012.03.011,
András Hollóa, Zsófia Clemensb clemenszsofia at gmail.com, Anita Kamondib, Péter Lakatosc, Anna Sz?csb
a National Institute for Medical Rehabilitation, H-1121 Budapest, Szanatórium u. 19, Hungary
b National Institute of Neuroscience, H-1145 Budapest, Amerikai út 57, Hungary
c Semmelweis University, 1st Department of Internal Medicine, H-1083 Budapest, Korányi Sándor u. 2/a, Hungary
There is growing interest concerning the role of vitamin D in various medical conditions such as diabetes and oncological, cardiovascular and central nervous system disorders. Although vitamin D deficiency is known to be highly prevalent among epilepsy patients, only a single study, published nearly forty years ago, assessed the effect of vitamin D on seizure control. Here, we measured serum 25-hydroxy-vitamin D (25(OH)D) levels and normalized it by administration of vitamin D3 in 13 patients with pharmacoresistant epilepsy. To see if vitamin D3 has an impact on seizure frequency, we compared seizure numbers during a 90-day period before and after treatment onset. We found that seizure numbers significantly decreased upon vitamin D3 supplementation. Median seizure reduction was 40%. We conclude that the normalization of serum vitamin 25(OH)D level has an anticonvulsant effect.
Normalizing probably means vitamin D levels > 30 nanogram, but it might mean > 20 nanogram.
See also VitaminDWiki
- Epilepsy category listing has
16 items along with related searches
- Overview Epileptic children and Vitamin D
- Epilepsy drugs decrease vitamin D levels – 2016
- Hypothesis – UV treat epilepsy – Feb 2011
- Epilepsy and deficiency of vitamin D and-or Magnesium – Feb 2013
- Children with epilepsy advised to take vitamin D – July 2013
- Attached at the bottom of this page: Epileptic seizures in a girl stopped with 6,000 IU of vitamin D daily
- Search VitaminDWiki for SEIZURES 291 items as of April 2014
See also web
Epilepsy seizures reduced by 40 percent after vitamin D levels normalized – April 2012
- Vitamin D Deficiency Among Children With Epilepsy in South Queensland PubMed Jan 2013
- What Causes Epilepsy Stanford
The causes of epilepsy can be divided into two groups: brain injuries and chemical imbalances in the brain.
Anything that injures the brain can lead to seizures. But in over half the cases no cause can be identified.
- See also Brain trauma and low vitamin D
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