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Epilepsy seizures reduced by 40 percent after vitamin D levels normalized – April 2012

Correction of vitamin D deficiency improves seizure control in epilepsy: A pilot study

Epilepsy & Behavior; Available online 11 April 2012
Brief Communication http://dx.doi.org/10.1016/j.yebeh.2012.03.011,
András Hollóa, Zsófia Clemensb clemenszsofia at gmail.com, Anita Kamondib, Péter Lakatosc, Anna Sz?csb
a National Institute for Medical Rehabilitation, H-1121 Budapest, Szanatórium u. 19, Hungary
b National Institute of Neuroscience, H-1145 Budapest, Amerikai út 57, Hungary
c Semmelweis University, 1st Department of Internal Medicine, H-1083 Budapest, Korányi Sándor u. 2/a, Hungary

There is growing interest concerning the role of vitamin D in various medical conditions such as diabetes and oncological, cardiovascular and central nervous system disorders. Although vitamin D deficiency is known to be highly prevalent among epilepsy patients, only a single study, published nearly forty years ago, assessed the effect of vitamin D on seizure control. Here, we measured serum 25-hydroxy-vitamin D (25(OH)D) levels and normalized it by administration of vitamin D3 in 13 patients with pharmacoresistant epilepsy. To see if vitamin D3 has an impact on seizure frequency, we compared seizure numbers during a 90-day period before and after treatment onset. We found that seizure numbers significantly decreased upon vitamin D3 supplementation. Median seizure reduction was 40%. We conclude that the normalization of serum vitamin 25(OH)D level has an anticonvulsant effect.


Normalizing probably means vitamin D levels > 30 nanogram, but it might mean > 20 nanogram.

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Attached files

ID Name Comment Uploaded Size Downloads
3062 Epilepsy stoped with vitamin D.pdf PDF 2013 admin 01 Oct, 2013 02:58 212.57 Kb 815
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