Serum 25-hydroxyvitamin D, frailty, and mortality among the Chinese oldest old: Results from the CLHLS study
Nutr Metab Cardiovasc Dis. 2021 Aug 26;31(9):2707-2715. doi: 10.1016/j.numecd.2021.05.033
Lin Liu 1, Chaolei Chen 1, Kenneth Lo 2, Jiayi Huang 1, Yuling Yu 1, Yuqing Huang 3, Yingqing Feng 4
Mortality category starts with:
People die sooner if they have low vitamin D
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28 Mortality Meta-analyses__
This list is automatically updated
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Maternal pregnancy problems if Vitamin D is less than 40 ng – meta-analysis Oct 2022
-
COVID-19 mortality extrapolates to zero at 50 ng of vitamin D – 18th Meta-analysis Sept 2021
-
Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
-
Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
-
People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019
-
Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019
-
Low Vitamin D is associated with dying sooner (70 studies) – meta-analysis Jan 2019
-
Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018
-
Review of meta-analyses of non-skeletal benefits of vitamin D (Mortality, RTI, etc) – July 2017
-
Chronic Kidney Disease mortality is 60 percent less likely if good vitamin D – meta-analysis July 2017
-
Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017
-
Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
-
Cardiovascular deaths 12 percent less likely if have 10 ng more vitamin D – meta-analysis March 2017
-
ICU patients 30 % less likely to die if have enough vitamin D – meta-analysis Nov 2016
-
Less likely to die if have enough vitamin D - Meta-analysis June 2014
-
Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
-
Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014
-
Vitamin D reduces risk of cause specific death, unless it is D2 – meta-analysis BMJ April 2014
-
More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014
-
Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014
-
Death of women from cancer 24% less likely if 20 ng more vitamin D – meta-analysis Sept 2013
-
Chance of dying increases by 25 percent in seniors if low vitamin D – Meta-analysis July 2013
-
Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013
-
Vitamin D with Calcium reduces mortality by 7 percent – meta-analysis May 2012
-
Death rate reduced 8 percent for 8 nanogram more vitamin D – meta-analysis Feb 2012
-
40 ng Vitamin D perhaps optimal for reduced mortality – Meta-analysis Jan 2012
-
Vitamin D3 but not D2 reduces mortality – meta-analysis July 2011
-
Vitamin D and mortality a meta-analysis of RCT - 2008
Items in both categories Seniors and Morality
-
Seniors 5.4 more likely to die if Vitamin D less than 15 ng (Mexico) – Aug 2023
-
Longevity and healthspan increased by Vitamin D - many studies
-
Less likely to die of various causes if higher Vitamin D (data from 300,000 people) – Oct 2022
-
Only 35,000 died in US of COVID who previously had been healthy
-
Oldest Chinese with low Vitamin D were more likely to die – Oct 2021
-
40 percent less likely to die if vitamin D was prescribed (10,000 VA patients, no surprise) – Oct 2021
-
Vitamin D supplementation and high levels reduce COVID-19 deaths in elderly – Review April 17, 2021
-
9X COVID-19 survival in nursing home if had 80,000 IU dose of vitamin D in previous month – Oct 2020
-
Respiratory deaths in seniors – 40 percent are attributable to low vitamin D – Aug 2020
-
Vitamin D predicts good health and long life in seniors, review of 20 cohort studies – Oct 2019
-
2 X more likely to die early if low vitamin D (80 year old Chinese) – April 2019
-
Low Vitamin D is associated with dying sooner (70 studies) – meta-analysis Jan 2019
-
Vitamin D In Older Women - Fractures, Frailty and Mortality – Buchebner thesis 2017
-
Much more likely to live longer if higher vitamin D – 27,000 seniors Feb 2017
-
Vitamin D supplementation can cost 50 dollars a day (live longer)
-
Women very low on vitamin D were 56 percent more likely to die in nursing home – Feb 2012
-
Vitamin D Omega 3 and Exercise are being used in controlled trial to support healthy ageing – Feb 2012
-
Low vitamin D associated with all-cause mortality and frailty – Mar 2011
-
Vitamin D deficiency was the best predictor of older patient death in hospital – May 2010
-
Table of outcomes for seniors vs vitamin D level
Frailty and Vitamin D - many studies
Download the PDF from VitaminDWiki
Background and aims: In this study, the aim is to explore whether frailty status modified the associations of serum 25(OH)D levels with all-cause and cause-specific mortality in the oldest old Chinese population.
Methods and results: A total of 1411 participants aged at least 80 years were enrolled in the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Information on serum 25(OH)D level, frailty status, and covariates were examined at baseline. All-cause and cause-specific mortality status were ascertained during the follow-up survey conducted in 2017-2018 by using the ICD-10 codes. Cox proportional hazard models with stratified analyses were performed to evaluate potential associations. Over a median follow-up of 3.2 years, 722 (51.2%) participants were deceased, including 202 deaths due to circulatory diseases, and 520 deaths due to noncirculatory causes.
After multivariable adjustment, the lowest quartile of serum 25(OH)D levels (Hazard Ratios (95% Confidence Intervals), 1.85 (1.45-2.36), 1.85 (1.45-2.36), 1.73 (1.31-2.29), respectively) and frailty (Odd Ratios (95% Confidence Intervals), 1.91 (1.60-2.29), 2.67 (1.90-3.74), 1.64 (1.31-2.05)) were associated with significantly higher risk of all-cause mortality, circulatory mortality, and noncirculatory mortality, respectively.
In addition, we observed significant interactions among 25(OH)D and frailty on the risk of all-cause and cause-specific mortality (all P-interaction < 0.001). Similar results were found in sensitivity analyses by excluding participants who died in the first year of follow-up and using clinical cutoffs of serum 25(OH)D levels.
Conclusion: Low serum 25(OH)D levels were associated with higher risk of all-cause and cause-specific mortality among the oldest old of the Chinese population, and the associations were significantly stronger in individuals with frailty.
Oldest Chinese with low Vitamin D were more likely to die – Oct 2021
2189 visitors, last modified 07 Oct, 2021,
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This list is automatically updated
- Maternal pregnancy problems if Vitamin D is less than 40 ng – meta-analysis Oct 2022
- COVID-19 mortality extrapolates to zero at 50 ng of vitamin D – 18th Meta-analysis Sept 2021
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019
- Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019
- Low Vitamin D is associated with dying sooner (70 studies) – meta-analysis Jan 2019
- Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018
- Review of meta-analyses of non-skeletal benefits of vitamin D (Mortality, RTI, etc) – July 2017
- Chronic Kidney Disease mortality is 60 percent less likely if good vitamin D – meta-analysis July 2017
- Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017
- Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
- Cardiovascular deaths 12 percent less likely if have 10 ng more vitamin D – meta-analysis March 2017
- ICU patients 30 % less likely to die if have enough vitamin D – meta-analysis Nov 2016
- Less likely to die if have enough vitamin D - Meta-analysis June 2014
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
- Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014
- Vitamin D reduces risk of cause specific death, unless it is D2 – meta-analysis BMJ April 2014
- More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014
- Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014
- Death of women from cancer 24% less likely if 20 ng more vitamin D – meta-analysis Sept 2013
- Chance of dying increases by 25 percent in seniors if low vitamin D – Meta-analysis July 2013
- Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013
- Vitamin D with Calcium reduces mortality by 7 percent – meta-analysis May 2012
- Death rate reduced 8 percent for 8 nanogram more vitamin D – meta-analysis Feb 2012
- 40 ng Vitamin D perhaps optimal for reduced mortality – Meta-analysis Jan 2012
- Vitamin D3 but not D2 reduces mortality – meta-analysis July 2011
- Vitamin D and mortality a meta-analysis of RCT - 2008
Items in both categories Seniors and Morality
- Seniors 5.4 more likely to die if Vitamin D less than 15 ng (Mexico) – Aug 2023
- Longevity and healthspan increased by Vitamin D - many studies
- Less likely to die of various causes if higher Vitamin D (data from 300,000 people) – Oct 2022
- Only 35,000 died in US of COVID who previously had been healthy
- Oldest Chinese with low Vitamin D were more likely to die – Oct 2021
- 40 percent less likely to die if vitamin D was prescribed (10,000 VA patients, no surprise) – Oct 2021
- Vitamin D supplementation and high levels reduce COVID-19 deaths in elderly – Review April 17, 2021
- 9X COVID-19 survival in nursing home if had 80,000 IU dose of vitamin D in previous month – Oct 2020
- Respiratory deaths in seniors – 40 percent are attributable to low vitamin D – Aug 2020
- Vitamin D predicts good health and long life in seniors, review of 20 cohort studies – Oct 2019
- 2 X more likely to die early if low vitamin D (80 year old Chinese) – April 2019
- Low Vitamin D is associated with dying sooner (70 studies) – meta-analysis Jan 2019
- Vitamin D In Older Women - Fractures, Frailty and Mortality – Buchebner thesis 2017
- Much more likely to live longer if higher vitamin D – 27,000 seniors Feb 2017
- Vitamin D supplementation can cost 50 dollars a day (live longer)
- Women very low on vitamin D were 56 percent more likely to die in nursing home – Feb 2012
- Vitamin D Omega 3 and Exercise are being used in controlled trial to support healthy ageing – Feb 2012
- Low vitamin D associated with all-cause mortality and frailty – Mar 2011
- Vitamin D deficiency was the best predictor of older patient death in hospital – May 2010
- Table of outcomes for seniors vs vitamin D level
Frailty and Vitamin D - many studies
Download the PDF from VitaminDWiki
Background and aims: In this study, the aim is to explore whether frailty status modified the associations of serum 25(OH)D levels with all-cause and cause-specific mortality in the oldest old Chinese population.
Methods and results: A total of 1411 participants aged at least 80 years were enrolled in the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Information on serum 25(OH)D level, frailty status, and covariates were examined at baseline. All-cause and cause-specific mortality status were ascertained during the follow-up survey conducted in 2017-2018 by using the ICD-10 codes. Cox proportional hazard models with stratified analyses were performed to evaluate potential associations. Over a median follow-up of 3.2 years, 722 (51.2%) participants were deceased, including 202 deaths due to circulatory diseases, and 520 deaths due to noncirculatory causes.
After multivariable adjustment, the lowest quartile of serum 25(OH)D levels (Hazard Ratios (95% Confidence Intervals), 1.85 (1.45-2.36), 1.85 (1.45-2.36), 1.73 (1.31-2.29), respectively) and frailty (Odd Ratios (95% Confidence Intervals), 1.91 (1.60-2.29), 2.67 (1.90-3.74), 1.64 (1.31-2.05)) were associated with significantly higher risk of all-cause mortality, circulatory mortality, and noncirculatory mortality, respectively.
In addition, we observed significant interactions among 25(OH)D and frailty on the risk of all-cause and cause-specific mortality (all P-interaction < 0.001). Similar results were found in sensitivity analyses by excluding participants who died in the first year of follow-up and using clinical cutoffs of serum 25(OH)D levels.
Conclusion: Low serum 25(OH)D levels were associated with higher risk of all-cause and cause-specific mortality among the oldest old of the Chinese population, and the associations were significantly stronger in individuals with frailty.
| 2189 visitors, last modified 07 Oct, 2021, |