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40 percent less likely to die if vitamin D was prescribed (10,000 VA patients, no surprise) – Oct 2021

The Effects of Vitamin D Supplementation and 25-Hydroxyvitamin D Levels on the Risk of Myocardial Infarction and Mortality

J Endocr Soc. 2021 Jul 15;5(10):bvab124. doi: 10.1210/jendso/bvab12
Prakash Acharya 1, Tarun Dalia 1, Sagar Ranka 1, Prince Sethi 1, Olurinde A Oni 2, Maya S Safarova 1, Deepak Parashara 1 2 3, Kamal Gupta 1, Rajat S Barua 1 2 3
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VitaminDWiki

No indication of dose size prescribed nor for how long
20,000 patient records spanning 19 years
They noticed that those whose vitamin D levels were raised from were 40% more likely to not die
They discarded the data from those whose values dropped back to less than 20 ng
VA appears to have a policy of prescribing Vitamin D if < 20 ng


It appears that VA learned that they might save money if they increased Vitamin D

VA found less testing for vitamin D resulted in increased health costs – Jan 2012
Click on image to see study from 2012


Mortality starts with:

People die sooner if they have low vitamin D
Mortality is.gd/VitaminDMortality
click on image for details

There are 280 articles in Mortality category


The Meta-analysis of Mortality and Vitamin D are listed here:

Likewise higher D ==> less COVID death - perhaps >40 ng is needed for COVID

 Download the PDF from VitaminDWiki

Objective: The aim of the study was to examine the effects of the vitamin D (Vit-D) treatment and nontreatment on Vit-D-deficient patients without a prior history of myocardial infarction (MI).

Materials and methods: This was a retrospective, observational, nested case-control study of patients (N = 20 025) with low 25-hydroxyvitamin D ([25-OH]D) levels (<20 ng/mL) who received care at the Veterans Health Administration from 1999 to 2018. Patients were divided into 3 groups:

  • Group A (untreated, levels ≤20 ng/mL),
  • Group B (treated, levels 21-29 ng/mL), and
  • Group C (treated, levels ≥30 ng/mL).

The risk of MI and all-cause mortality were compared utilizing propensity score-weighted Cox proportional hazard models.

Results: Among the cohort of 20 025 patients, the risk of MI was significantly lower in Group C than in Group B (hazard ratio [HR] 0.65, 95% CI 0.49-0.85, P = .002) and Group A (HR 0.73, 95% CI 0.55-0.96), P = .02). There was no difference in the risk of MI between Group B and Group A (HR 1.14, 95% CI 0.91-1.42, P = 0.24).
Compared with Group A, both

  • Group B (HR 0.59, 95% CI 0.54-0.63, P < .001) and
  • Group C (HR 0.61, 95% CI 0.56-0.67, P < .001)

had significantly lower all-cause mortality.
There was no difference in all-cause mortality between Group B and Group C (HR 0.99, 95% CI 0.89-1.09, P = .78).

Conclusions: In patients with Vit-D deficiency and no prior history of MI, treatment to the (25-OH)D level of >20 ng/mL and >30 ng/mL was associated with a significantly lower risk of all-cause mortality. The lower risk of MI was observed only in individuals maintaining (25-OH)D levels ≥30 ng/mL.
Short URL= https://is.gd/acharya2021


Created by admin. Last Modification: Saturday August 21, 2021 23:08:28 GMT-0000 by admin. (Version 13)

Attached files

ID Name Comment Uploaded Size Downloads
16081 20 vs 30.jpg admin 16 Aug, 2021 13:29 23.42 Kb 117
16080 20-29.jpg admin 16 Aug, 2021 13:28 22.29 Kb 125
16079 all-cause.jpg admin 16 Aug, 2021 13:28 79.25 Kb 136
16078 Myocardial Infarction 20,000.pdf PDF - 2021 admin 16 Aug, 2021 13:27 656.65 Kb 128
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