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Longevity and healthspan increased by Vitamin D - many studies

VitaminDWiki pages with LONGEVITY etc in title (29 as of April 2023)

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Items found: 29
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Longevity and healthspan increased by Vitamin D - many studies 06 Apr, 2023
Magnesium Role in Health and Longevity - many studies 18 Oct, 2022
Vitamin D supplementation is associated with slower epigenetic aging - May 2022 21 Jun, 2022
Epigenetics, vitamin D, and Multiple Sclerosis 15 Jun, 2022
Vitamin D might increase lifespan – clinical trial with 5,000 mice - June 2021 06 Jun, 2021
Epigenetics - PDFs and links, with and without Vitamin D 25 Feb, 2021
Epigenetics identified Cervical Cancer 100 percent of time – 2019 23 Dec, 2019
Longevity expert (David Sinclair) supplements includes Vitamin D, Vitamin K, and Resveratrol – Sept 2019 30 Sep, 2019
Lifespan and healthspan extension by resveratrol - Jan 2015 28 Apr, 2019
Stressors as a fetus or child can cause health problems in adult (perhaps via epigenetics) – Dec 2017 14 Oct, 2018
Health problems can persist through many generations – Epigenetics and Vitamin D 13 Oct, 2018
Epigenetics meets endocrinology – 2011 13 Oct, 2018
Vitamin D Receptor – environment, genetics and epigenetics – May 2015 13 Oct, 2018
Healthspan is more important than Lifespan – JAMA Oct 2018 02 Oct, 2018
Centenarians have good Vitamin D Receptors (longevity is also increased by higher Vit D levels) – Aug 2016 24 Jul, 2017
Avoiding the sun reduces lifespan by 2 years (smoking reduces lifespan by 10 years) – March 2016 09 Jun, 2017
Sunbathing (vitamin D) increases lifespan in Sweden by about 1 year – March 2016 09 Jun, 2017
Vitamin D extends lifespan about 60 percent (for worms in a lab) – Oct 2016 26 Oct, 2016
Low vitamin D in pregnancy – epigenetic pancreas problems in offspring (mice) – May 2016 05 May, 2016
Epigenetics of Multiple Sclerosis – March 2014 06 Sep, 2015
Micronutrients, methylation, epigenetics, longevity podcast by Rhonda Patrick and Tim Ferriss - June 2015 22 Jun, 2015
Epigenetics meets endocrinology - 2011 21 Jan, 2015
Hypothesis: Epigenetics, vitamin D, and Multiple Sclerosis – Nov 2012 29 Aug, 2014
Epigenetics of prostate cancer and vitamin D – June 2010 09 Jul, 2013
Off topic: Special issue on Longevity in the Journal Nature - free text Dec 2012 07 Dec, 2012
If you have inherited longevity genes you can take 200 IU less vitamin D - Nov 2012 09 Nov, 2012
Lung disease, vitamin D, and epigenetics – Aug 2011 13 Feb, 2012
Every hour of TV watched reduces your lifespan by 22 minutes – Aug 2011 26 Aug, 2011
Epigenetics and vitamin D – June 2010 clips from the web 05 Jun, 2010

Search Google Scholar for this topic: 75,000 hits April 2023

(Longevity OR Lifespan OR Healthspan) "vitamin d"

  • Association of Vitamin D Receptor with Longevity and Healthy Aging - 2013 FREE PDF
  • Investigational drugs and nutrients for human longevity. Recent clinical trials registered in ClinicalTrials.gov and clinicaltrialsregister.eu - Jun 2021, FREE PDF - includes 2 vitamin D megatrials
  • Vitamin D in physiological and pathological aging: Lesson from centenarians - October 2019 FREE PDF

VitaminDWiki Mortality category contains

People die sooner if they have low vitamin D
Mortality is.gd/VitaminDMortality
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There are 293 articles in Mortality category

28 Mortality Meta-analyses

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Methylation of Vitamin D genes changes vitamin D getting to cells- Dec 2016

Relationship between methylation status of vitamin D-related genes, vitamin D levels, and methyl-donor biochemistry
Journal of Nutrition & Intermediary Metabolism Volume 6, December 2016, Pages 8-15 https://doi.org/10.1016/j.jnim.2016.04.010
Emma LouiseBeckett a b KonstaDuesingb CharlotteMartina PatriceJonesa JohnFurstcKatrina KingdSuzanne Niblettd ZoeYatese Martin Veysey df Mark Lucocka


  • Plasma 25(OH)D positively correlates with methylation status of the vitamin D receptor gene.
  • Vitamin D status relates to the methylation status of the genes of key enzymes involved in vitamin D metabolism.
  • DNA methylation may influence vitamin D metabolism, possibly explaining varied responses to intake.
  • Methyl-donor related biochemistry (serum folate, B12, plasma homocysteine) does not significantly alter these relationships.

Vitamin D is known for its role in the regulation of gene expression via the vitamin D receptor, a nuclear transcription factor. More recently, a role for vitamin D in regulating DNA methylation has been identified as an additional mechanism of modulation of gene expression. How methylation status influences vitamin D metabolism and response pathways is not yet clear.
Therefore, we aimed to assess the relationship between plasma 25-hydroxycholecalciferol (25(OH)D) and the methylation status of

  • vitamin D metabolism enzyme genes (CYP2R1, CYP27B1 and CYP24A1) and the
  • vitamin D receptor gene (VDR).

This analysis was conducted in the context of dietary vitamin D, and background methyl donor related biochemistry, with adjustment for several dietary and lifestyle variables. Percentage methylation at CpG sites was assessed in peripheral blood cells using methylation sensitive and dependent enzymes and qPCR. Standard analytical techniques were used to determine plasma 25(OH)D and homocysteine, and serum folate and B12, with the relationship to methylation status assessed using multi-variable regression analysis. CYP2R1 and VDR methylation were found to be independent predictors of plasma 25(OH)D, when adjusted for vitamin D intake and other lifestyle variables. CYP24A1 was related to plasma 25(OH)D directly, but not in the context of vitamin D intake. Methyl-group donor biochemistry was associated with the methylation status of some genes, but did not alter the relationship between methylation and plasma 25(OH)D.
Modulation of methylation status of CYP2R1, CYP24A1 and VDR in response to plasma 25(OH)D may be part of feedback loops involved in maintaining vitamin D homeostasis, and may explain a portion of the variance in plasma 25(OH)D levels in response to intake and sun exposure. Methyl-group donor biochemistry, while a potential independent modulator, did not alter this effect.
 Download the PDF from VitaminDWiki

Vitamin D supplementation is associated 2 year slower epigenetic aging - May 2022

GeroScience volume 44, pages 1847–1859 (2022)
Valentin Max Vetter, Yasmine Sommerer, Christian Humberto Kalies, Dominik Spira, Lars Bertram & Ilja Demuth 

Adverse effects of low vitamin D level on mortality and morbidity are controversially discussed.
Especially older people are at risk for vitamin D deficiency and therefore exposed to its potentially harmful consequences.
A way of measuring differences in the biological age is through DNA methylation age (DNAm age) and its deviation from chronological age, DNAm age acceleration (DNAmAA).
We previously reported on an association between vitamin D deficiency and higher 7-CpG DNAmAA in participants of the Berlin Aging Study II (BASE-II). In this study, we employ a quasi-interventional study design to assess the relationship between DNAmAA of five epigenetic clocks and vitamin D supplementation.
Longitudinal data were available for 1,036 participants of BASE-II that were reexamined on average 7.4 years later in the GendAge study (mean age at follow-up: 75.6 years, SD = 3.8 years, age range: 64.9–94.1 years, 51.9% female).
DNAmAA was estimated with the

  • 7-CpG clock,
  • Horvath’s clock,
  • Hannum’s clock,
  • PhenoAge, and
  • GrimAge.

Methylation data were obtained through methylation-sensitive single nucleotide primer extension (MS-SNuPE) or Illumina’s Infinium “MethylationEPIC” array. Vitamin D–deficient participants who chose to start vitamin D supplementation after baseline examination showed a

  • 2.6-year lower 7-CpG DNAmAA (p = 0.011) and
  • 1.3-year lower Horvath DNAmAA (p = 0.042)

compared to untreated and vitamin D–deficient participants.
DNAmAA did not statistically differ between participants with successfully treated vitamin D deficiency and healthy controls (p > 0.16).
Therefore, we conclude that intake of vitamin D supplement is associated with lower DNAmAA in participants with vitamin D deficiency.
 Download the PDF from VitaminDWiki

Examine.com reviewed this study

Int. J. Mol. Sci. 2022, 23(20), 12292; https://doi.org/10.3390/ijms232012292
by Ashmika Foolch etc.

The highly transmittable and infectious COVID-19 remains a major threat worldwide, with the elderly and comorbid individuals being the most vulnerable. While vaccines are currently available, therapeutic drugs will help ease the viral outbreak and prevent serious health outcomes. Epigenetic modifications regulate gene expression through changes in chromatin structure and have been linked to viral pathophysiology. Since epigenetic modifications contribute to the life cycle of the virus and host immune responses to infection, epigenetic drugs are promising treatment targets to ameliorate COVID-19. Deficiency of the multifunctional secosteroid hormone vitamin D is a global health threat. Vitamin D and its receptor function to regulate genes involved in immunity, apoptosis, proliferation, differentiation, and inflammation. Amassed evidence also indicates the biological relations of vitamin D with reduced disease risk, while its receptor can be modulated by epigenetic mechanisms. The immunomodulatory effects of vitamin D suggest a role for vitamin D as a COVID-19 therapeutic agent. Therefore, this review highlights the epigenetic effects on COVID-19 and vitamin D while also proposing a role for vitamin D in COVID-19 infections.
 Download the PDF from VitaminDWiki

VitaminDWiki is trying to arrange a 30,000 person vitamin D trial - which may show improved longevity

2 Vitamin D megatrials (>5,000 people) on reducing all-cause mortality are underway - 2021

Investigational drugs and nutrients for human longevity. Recent clinical trials registered in ClinicalTrials.gov and clinicaltrialsregister.eu
https://doi.org/10.1080/13543784.2021.1939306 FREE PDF

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Attached files

ID Name Comment Uploaded Size Downloads
18844 Epigenetics, COVID_CompressPdf.pdf admin 20 Nov, 2022 21:59 302.15 Kb 55
18843 slower epigenetic aging_CompressPdf.pdf PDF 2022 admin 20 Nov, 2022 21:50 263.03 Kb 50
18842 methylation Dec 2016.pdf admin 20 Nov, 2022 21:41 612.12 Kb 49