Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men.
Sci Rep. 2017 Jan 3;7:39697. doi: 10.1038/srep39697.
Virtanen JK1, Giniatullin R2,3, Mäntyselkä P1,4, Voutilainen S1, Nurmi T1, Mursu J1, Kauhanen J1, Tuomainen TP1.
1Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
2Department of Neurobiology, A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland.
3Laboratory of Neurobiology, Kazan Federal University, Kazan, Russia.
4Primary Health Care Unit, Kuopio University Hospital, Finland.
- People in this study had Ischaemic Heart Disease and lived in Eastern Finland – far from the equator
- Frequent Headache (weekly or daily): 2.16 less likely if > 22 ng vs <12 ng
See also VitaminDWiki
- Headache category listing has
30 items along with related searches
- Migraine headaches reduced with 50,000 IU vitamin D weekly – RCT July 2015
- Hypothesis– Chronic headache and musculoskeletal pain both result from low vitamin D – Oct 2013
- Cluster headaches substantially reduced by 10,000 IU of Vitamin D in 80 percent of people
More physical activity, More with good/excellent health, Less likely smoke, Fewer strokes, Less Diabetes
Vitamin D has been suggested to have a role in various neurovascular diseases, but the data regarding headache is inconclusive. Our aim was to investigate the associations between serum 25-hydroxyvitamin D [25(OH)D], a marker for vitamin D status, and risk of frequent headache. The study population consisted of 2601 men from the population-based Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) from eastern Finland, aged 42-60 years in 1984-1989. The cross-sectional associations with prevalence of self-reported frequent headache (defined as weekly or daily headaches) were estimated with multivariable-adjusted odds ratios. The average serum 25(OH) concentration was 43.4 nmol/L (SD 18.9, min-max 7.8-136.1 nmol/L). A total of 250 men (9.6%) reported frequent headache. The average serum 25(OH)D concentration among those with frequent headache was 38.3 nmol/L (SD 18.8) and 43.9 nmol/L (SD 18.9) among those without frequent headache, after adjustment for age and year and month of blood draw (P for difference <0.001). After multivariable adjustments, those in the lowest vs. the highest serum 25(OH)D quartile had 113% (95% CI 42, 218%; P for trend <0.001) higher odds for frequent headache. In conclusion, low serum 25(OH)D concentration was associated with markedly higher risk of frequent headache in men.
PMID: 28045039 DOI: 10.1038/srep39697