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Melanoma not as thick if recently had a sunny vacation – Nov 2013

Sunny Holidays before and after Melanoma Diagnosis Are Respectively Associated with Lower Breslow Thickness and Lower Relapse Rates in Italy.

PLoS One. 2013 Nov 4;8(11):e78820. doi: 10.1371/journal.pone.0078820.
Gandini S, De Vries E, Tosti G, Botteri E, Spadola G, Maisonneuve P, Martinoli C, Joosse A, Ferrucci PF, Baldini F, Cocorocchio E, Pennacchioli E, Cataldo F, Bazolli B, Clerici A, Barberis M, Bataille V, Testori A.
Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy.

BACKGROUND: Previous studies have reported an association between sun exposure and improved cutaneous melanoma (CM) survival. We analysed the association of UV exposure with prognostic factors and outcome in a large melanoma cohort.

METHODS: A questionnaire was given to 289 (42%) CM patients at diagnosis (Group 1) and to 402 CM patients (58%) during follow-up (Group 2). Analyses were carried out to investigate the associations between sun exposure and melanoma prognostic factors and survival.

RESULTS: Holidays in the sun two years before CM diagnosis were significantly associated with lower Breslow thickness (p=0.003), after multiple adjustment.
Number of weeks of sunny holidays was also significantly and inversely associated with thickness in a dose-dependent manner (p=0.007).
However when stratifying by gender this association was found only among women (p=0.0004) the risk of CM recurrence in both sexes was significantly lower in patients (n=271) who had holidays in the sun after diagnosis, after multiple adjustment including education: HR=0.30 (95%CI:0.10-0.87; p=0.03)

CONCLUSIONS: Holidays in the sun were associated with thinner melanomas in women and reduced rates of relapse in both sexes.
However, these results do not prove a direct causal effect of sun exposure on survival since other confounding factors, such as vitamin D serum levels and socio-economic status, may play a role.
Other factors in sun seeking individuals may also possibly affect these results.

PMID: 24223851

Fewer with thick melanoma (>4 mm) if vacation

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Fewer with thick melanoma - even better if 3 week vacation

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Help women especially

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Also less recurrence if have sunny vacation

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PDF is attached at the bottom of this page

Possible reasons include

  1. Vitamin D from the sun provided reduced cancer (probably internal as well as external cancer)
    Can also get vitamin D from supplements
  2. Less likely to have sunburn on a sunny vacation than on a sunny weekend

See also VitaminDWiki

Attached files

ID Name Comment Uploaded Size Downloads
3276 Sunny4a.jpg admin 14 Nov, 2013 18:22 31.94 Kb 752
3275 Sunny 3c.jpg admin 14 Nov, 2013 18:22 35.70 Kb 817
3274 Sunny 2b.jpg admin 14 Nov, 2013 18:22 53.61 Kb 870
3273 Sunny 2a.jpg admin 14 Nov, 2013 18:21 55.11 Kb 883
3272 Sunny vacation reduces risk of melanoma.pdf PDF - 2013 admin 14 Nov, 2013 18:21 729.85 Kb 573
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