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Melanoma 2.1 X more likely if low vitamin D – meta-analysis Jan 2020


The Association Between Serum Vitamin D Level and Risk and Prognosis of Melanoma: A Systematic Review and Meta-Analysis

J Eur Acad Dermatol Venereol, 2020 Jan 9, DOI: 10.1111/jdv.16189
Tsung-Yu Tsai 1, Che-Yuan Kuo 2, Yu-Chen Huang 1 3

Background: Vitamin D has antineoplastic effects, but the synthesis of vitamin D requires ultraviolet radiation, a known risk factor for melanoma.

Objective: To investigate the correlations between serum vitamin D levels and risk and prognosis of melanoma.

Methods: A systematic review and meta-analysis was conducted. Online databases were searched on Oct 31, 2018.

Results: Twenty-five studies with a total of 11166 patients with melanoma were included. There was no significant difference in serum vitamin D levels between patients with melanoma and controls (standardized mean difference [SMD], -0.185; 95% confidence interval [CI], -0.533-0.162). However, the prevalence of vitamin D deficiency was significantly higher in patients with melanoma than that in controls (odds ratio, 2.115; 95% CI, 1.151-3.885). In terms of prognosis, serum vitamin D levels were significantly higher in melanoma patients with lower Breslow thickness (≦ 1 mm vs > 1 mm: SMD, 0.243; 95% CI, 0.160-0.327).
Moreover, melanoma patients with lower vitamin D levels had a significantly higher mortality rate (hazard ratio, 1.558; 95% CI, 1.258-1.931).

Conclusions: Vitamin D deficiency is associated with higher Breslow thickness and mortality in melanoma patients.


VitaminDWiki pages with MELANOMA in title (41 as of Jan 2022)

This list is automatically updated

Items found: 42
Title Modified
Melanoma might be suppressed by Vitamin D - many studies 25 Nov, 2022
Melanoma Cancer detected more often (perhaps due to infrequent intense UVA) – Oct 2022 07 Oct, 2022
Overview Suntan, melanoma and vitamin D 28 Nov, 2021
Melanoma not treated by small doses of vitamin D (100,000 IU every 50 days) – RCT June 2021 30 Jun, 2021
Melanoma huge increase - perhaps due to use of sunscreen or lower vitamin D - Aug 2014 26 Apr, 2021
Melanoma associated with vitamin D less than 30 ng (9X) – March 2021 13 Mar, 2021
Recurrence of malignant melanoma may be reduced by 100,000 IU of vitamin D monthly – trial underway 2017 13 Mar, 2021
Melanoma 25 X more likely if low vitamin D – Feb 2018 13 Mar, 2021
Sunlight on skin has decreased 9X while melanoma has increased 30X – Feb 2020 20 Feb, 2020
Melanoma 2.1 X more likely if low vitamin D – meta-analysis Jan 2020 11 Jan, 2020
Melanoma cancer growth slowed by increased Vitamin D Receptor (yet again) – Oct 2019 06 Nov, 2019
Melanoma Is a Disease of Office Workers - Dec 2018 12 Dec, 2018
Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018 20 Nov, 2018
UVB improvements to Vitamin D receptor appear to improve melanoma survival – Oct 2017 09 Oct, 2017
Non-melanoma skin cancer varies with latitude, melanoma does not – April 2017 23 May, 2017
Malignant melanoma may be reduced by skin-activated vitamin D – Nov 2016 27 Jan, 2017
People with metastatic melanoma and initially Vitamin D deficient had 4.7 times worse outcome if not get enough D – Dec 2016 31 Dec, 2016
Vitamin D being considered for Melanoma – active vitamin D is produced by skin – Nov 2016 01 Dec, 2016
Melanoma survival doubled with Vitamin D binding protein polymorphism – Nov 2015 18 Nov, 2015
Will vitamin D loading dose and 50,000 IU monthly will help after melanoma surgery – Oct 2014 24 Oct, 2014
Melanoma REDUCED by those getting the most UV, unless 5 blistering sunburns while in teen years – June 2014 05 Jun, 2014
Death from melanoma (without ulcers) greatly decreased if have lots of vitamin D receptors – May 2014 28 May, 2014
Melanoma and Vitamin D genes - multiple papers 22 Mar, 2014
Subsequent melanomas associated with BsmI gene variation of VDR– May 2011 22 Mar, 2014
Melanoma risk 2X to 4X higher if Vitamin D receptor genes had morphed – March 2014 19 Mar, 2014
Decreased risk of non-melanoma skin cancer by working outdoors in Europe – April 2013 22 Dec, 2013
UV and Melanoma: are they related – 2013 19 Dec, 2013
The Protective Role of Vitamin D Signaling in Non-Melanoma Skin Cancer - Nov 2013 14 Dec, 2013
Melanoma is 44 percent LESS LIKELY if get sun on the job – Nov 2013 01 Dec, 2013
Melanoma not as thick if recently had a sunny vacation – Nov 2013 14 Nov, 2013
UVA most likely causes melanoma to progress– Sept 2011 10 Nov, 2013
Prostate Cancer increased melanoma rate by 2X (vitamin D not mentioned) Nov 2013 09 Nov, 2013
Melanoma and Vitamin D - association is not certain - 2012 14 Jul, 2013
Melanoma reduces by half the amount of vitamin D activated by the skin – March 2013 17 Apr, 2013
Melanoma less likely when far from equator – Oct 2012 07 Dec, 2012
Red-haired mice can get melanoma without UV - Oct 2012 29 Nov, 2012
Hypothesis – worldwide increase in Melanoma due to UVA – Oct 2011 17 Oct, 2012
Sun exposure is associated with increased survival from melanoma – 2005 07 Oct, 2012
No association found between melanoma and low vitamin D levels – Sept 2012 12 Sep, 2012
UVB, Smoking and second cancers after melanoma – Jan 2012 06 Mar, 2012
Perhaps 28-40 ng of vitamin D would be good for Melanoma patients – Feb 2011 06 Mar, 2011
Study Suggests Indoor Tanning Boosts Chances of Melanoma 27 May, 2010


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