Osteoporosis International volume 20, Article number: 1407 (2009)
C. J. Bacon, G. D. Gamble, A. M. Horne, M. A. Scott & I. R. Reid
Loading Dose of Vitamin D category has the following
see also Overview Loading of vitamin D Overview Toxicity of vitamin D
Injection category listing has
It appears that over 1 million Vitamin D loading doses have been taken
Doses ranged from 100,000 to 600,000 IU over a period of a day to a month
No reports of adverse reactions
Many studies report on the benefits resulting from loading doses
~~#00F:The TOP articles in Loading Dose of Vitamin D are listed here: __
- Elderly Vitamin D Loading Dose of 500,000 IU is safe and effective – RCT 2009
- Low trauma bone fractures in seniors – considering Vitamin D loading dose for all, without testing – Nov 2019
- Common cause of dizziness (BPPV) reduced 5 X by several doses of 50,000 IU of vitamin D – 2015, 2016
- Vitamin D levels of seniors restored with 50,000 IU weekly for 8 weeks – April 2014
- Vitamin D for Italians – Senior 2300 IU, if deficient loading dose of at least 300,000 IU– Med Society 2011
- 600,000 IU vitamin D normalized virtually all seniors in 3 months (Injection better than oral)– May 2012
- Half of the seniors needed more than 1700 IU vitamin D3 (50000 monthly) – April 2011
- 300,000 IU vitamin D helped seniors in many ways – May 2011
- Vitamin D3 loading dose of 500,000 IU for elderly – Aug 2009
Daily dosing with vitamin D often fails to achieve optimal outcomes, and it is uncertain what the target level of 25-hydroxyvitamin D should be. This study found that large loading doses of vitamin D3 rapidly and safely normalize 25OHD levels, and that monthly dosing is similarly effective after 3–5 months. With baseline 25OHD > 50 nmol/L, vitamin D supplementation does not reduce PTH levels.
There is concern that vitamin D supplementation doses are frequently inadequate, and that compliance with daily medication is likely to be suboptimal.
This randomized double-blind trial compares responses to three high-dose vitamin D3 regimens and estimates optimal 25-hydroxyvitamin D (25OHD) levels, from changes in parathyroid hormone (PTH), and procollagen type I amino-terminal propeptide (P1NP) in relation to baseline 25OHD. Sixty-three elderly participants were randomized to three regimens of vitamin D supplementation: a 500,000-IU loading dose; the loading dose plus 50,000 IU/month; or 50,000 IU/month.
The Loading and Loading + Monthly groups showed increases in 25OHD of 58 ± 28 nmol/L from baseline to 1 month. Thereafter, levels gradually declined to plateaus of 69 ± 5 nmol/L and 91 ± 4 nmol/l, respectively. In the Monthly group, 25OHD reached a plateau of ~80 ± 20 nmol/L at 3–5 months. There were no changes in serum calcium concentrations. PTH and P1NP were only suppressed by vitamin D treatment in those with baseline 25OHD levels <50 and <30 nmol/L, respectively.
Large loading doses of vitamin D3 rapidly and safely normalize 25OHD levels in the frail elderly. Monthly dosing is similarly effective and safe, but takes 3–5 months for plateau 25OHD levels to be reached.
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