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Autoimmune Hepatitis 8X more likely if low vitamin D – Dec 2014

Low Serum Vitamin D Levels Are Associated with Severe Histological Features and Poor Response to Therapy in Patients with Autoimmune Hepatitis

Digestive Diseases and Sciences, December 2014, Volume 59, Issue 12, pp 3035-3042
Cumali Efe, Taylan Kav, Cisel Aydin, Mustafa Cengiz, Narin Nasıroglu Imga, Tugrul Purnak, Daniel S. Smyk, Murat Torgutalp, Turan Turhan, Seren Ozenirler

PDF is available free at Sci-Hub   10.1007/s10620-014-3267-3



Background and Aim
25-Hydroxyvitamin D [25(OH)D] has an important role in fibrosis progression and inflammatory response in patients with various etiologies of chronic liver disease. However, its influence on autoimmune hepatitis (AIH) has not been investigated. We evaluated the association of serum 25(OH)D levels with clinical, biochemical and histological features and response to therapy in AIH.

Materials and methods: Serum 25(OH)D levels were quantified in 68 therapy naïve AIH patients and 34 healthy controls.

Mean serum 25(OH)D levels were significantly lower in AIH compared to healthy controls (16.8 ± 9.2 vs. 35.7 ± 13.6, p < 0.0001). Low levels of 25(OH)D (<30 µg/L) were independently associated with advance fibrosis and severe interface hepatitis in AIH patients [p = 0.014; odds ratio (OR) 0.12, 95 % confidence interval (CI) 0.02–0.65 and p = 0.020; OR 0.17, 95 % CI 0.04–0.76, respectively].
Severe 25(OH)D deficiency (<10 µg/L) was associated with

  • advance fibrosis,
  • severe interface hepatitis,
  • low platelet counts and
  • sampling time in a univariate analysis.

Only interface hepatitis and fibrosis scores were independently associated with 25(OH)D deficiency in a multiple regression analysis (p = 0.005; OR 0.12, 95 % CI 0.03–0.53 and p = 0.022; OR 0.15, 95 % CI 0.03–0.75, respectively).
Mean serum 25(OH)D levels were lower in non-responders compared to responders (9.2 ± 4.8 vs. 17.1 ± 9.4, p = 0.015), and 25(OH)D deficiency was more commonly observed in non-responders than the responders (80 vs. 43 %, p = 0.036).

Low 25(OH)D levels are associated with advance fibrosis and severe inflammation in AIH. Our study suggests that vitamin D may be a potential biomarker that predicts response to therapy and histological features in AIH.


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See also VitaminDWiki

Diabetes age-adjusted
Diabetes (CDC)
see wikipage: http://www.vitamindwiki.com/tiki-index.php?page_id=339
Obesity- kids 150%
Obesity WikiPedia.gif
from: http://www.iuns.org/features/obesity/obesity.htm
Multiple Sclerosis 70 %
MS Increase
Autism 250 %
updated from http://autisminnb.blogspot.com/2011/01/autism-speaks-cdc-autism-prevalence.html
Ulcerative Colitis 210 %
UC and Crohn's
Crohn's Disease
Crohn's Disease.png
Hospitalizations for Food Allergy 260 %
Metabolic Syndrome 250 %

Attached files

ID Name Comment Uploaded Size Downloads
10715 Fibrosis scores.jpg admin 20 Oct, 2018 15.02 Kb 1570
10714 hepatitis severity.jpg admin 20 Oct, 2018 14.61 Kb 1159
4612 Autoimmune book.jpg admin 22 Nov, 2014 14.50 Kb 19506