#### https://www.youtube.com/watch?v=jeLC_b5gDUM YouTube Video

**Presentation on vitamin D to Smart Life Forum in Palo Alto on Oct. 17, 2017**

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** Download the slides from VitaminDWiki**

- Dr. Grant on vitamin D and mortality in VitaminDWiki
- Bibliography of Black-White health disparities linked to vitamin D - Dr. Grant March 2017
- Pregnancy and Vitamin D bibliography - Dr. Grant - March 2017
- Low UVB (thus low Vitamin D) is linked to many diseases – Grant Jan 2016
- Autism and vitamin D: Cannell, Grant – March 2013
- Solar UVB reduces Cancer Risk – Grant, Jan 2013

#### Slide titles

Vitamin D Physiology

Serum Calcium Regulation

Other Actions of Vitamin D

More Actions of Vitamin D

Skin Pigmentation

Human Skin Color Distribution

Recommendations

Leaders of the Two Camps

Vitamin D from UVB Exposure

Other Effects of UV Exposure

Those Most Likely to Have Low 25(OH)D Concentrations

Value of Measuring 25(OH)D

Benefits of Higher 25(OH)D(Partial List)

Colon Cancer Mortality Rates, White Males, 1950-69

Types of Cancer Reduced by UVB Exposure in the U.S.

Breast Cancer Incidence Odds Ratio vs. 25(OH)D Concentration

Cardiovascular DiseaseMeta-analysis

Seasonal Influenza

Pregnancy

Benefits of Vitamin D during Pregnancy

An estimate of the global reduction in mortality rates through doubling vitamin D levels.

Athletic Performance

From VitaminDCouncil.org by John Cannell (2010)

Autism Prevalence, White Children, vs. UVB dose for October

ADHD Prevalence 2007 From the CDC

Dental Caries Rate for Servicemen, 1918-1934 vs. UVB Dose

Dental Caries – Vitamin D Clinical Trials Hujoel, 2012

Sleep

Vitamin D and Verbal Fluency

Vitamin D Status and Rates of Cognitive Decline in a Multiethnic Cohort of Older Adults

Alzheimer’s and DementiaProspective Study 5.6 yrs

Erectile Dysfunction

Testosterone - 1, Testosterone - 2

Surgery

Where is Vitamin D Policy Headed?

Why Vitamin D Clinical Trials Should Be Based on 25(OH)D Concentrations

Variation of 25(OH)D Concentration with Oral Vitamin D Intake

Necessity for Vitamin D Clinical Trials

Why vitamin D clinical trials should be based on 25(OH)D concentrations - 2

#### English transcript

00:0X all right our next speaker is Bill I say

00:0X William B Grant has a PhD in physics

00:0X from the University of California Berkeley

00:1X in 1971 he has had a 30-year career in

00:1X atmospheric sciences with an emphasis on

00:1X laser remote sensing of atmospheric

00:1X constituents such as ozone and aerosols

00:2X with positions at s RI International the

00:2X Jet Propulsion Laboratory California

00:2X Institute of Technology and NASA Langley

00:3X Research Center he turned to health

00:3X research in 1996 publishing the first

00:3X paper linking diet to risk of

00:4X Alzheimer's disease in 1997 followed by

00:4X his studies of sugar fat and coronary

00:4X heart disease in 1998 and animal

00:4X products and cancer risk in 1998 in 1999

00:5X he turned his attention to the role of

00:5X solar ultraviolet B exposure in reducing

00:5X risk of many types of cancer through

01:0X production of vitamin D in 2012 after

01:0X retirement from NASA in 2000 2002 after

01:0X retirement from NASA in 2004 he moved to

01:1X San Francisco and formed the nonprofit

01:1X organization sunlight nutrition and

01:1X health research center which is WWN arc

01:2X AR CSUN AR c.org where he spends most of

01:2X his time studying the role of UVB solar

01:3X UVB exposure and vitamin D in reducing

01:3X risk of cancer and many other types of

01:3X disease he also investigates the role of

01:3X diet in risk of Alzheimer's disease in

01:4X cancer he has about 300 health

01:4X publications listed at WWE become of

01:4X which 210 are related to vitamin D with

01:5X 78% of these also on ultraviolet

01:5X radiation in human health and 41 to diet

01:5X and disease please welcome Bill Graham

02:0X thank you I'm delighted to be back here

02:0X again I really have enjoyed this

02:1X organization I like cork you invited me

02:1X into it about 12 or 13 years ago and

02:1X I've didn't involve ever since but don't

02:1X come to meetings very often now because

02:1X it's I'm in the San Francisco and it's a

02:2X long way down here and back let's see

02:2X there you go

02:2X I do receive funding from biotech pharmacal

02:3X that's a vitamin company as a

02:3X supplier of research grade vitamin D for

02:3X health professionals and consumers they

02:3X have a website biotech for McHale calm

02:4X so I'm going to discuss a number of

02:4X topics related to vitamin D this evening

02:4X first of all the vitamin D physiology

02:4X then I'm gonna put the binding

02:5X recommendations right up in front

02:5X because I think that's what you're most

02:5X interested in then I'll tell you why if

02:5X I'd be is important in terms of which

02:5X health outcomes are related to low

03:0X vitamin D whereas the Bundy policy

03:0X hitted so my latest research on how

03:0X vitamin D clinical trial should be

03:1X conducted and then tell you where to go

03:1X for additional information so vitamin d3

03:2X that's cholecalciferol can be made in

03:2X the skin or obtained from a food of

03:2X supplements there's also a vitamin d3

03:2X aerial cuss difficult which is made from

03:3X mushrooms or yeast or fun gene that's

03:3X not as effective as vitamin d3 it

03:3X doesn't last as long and it's not clear

03:4X that it has the same health benefits but

03:4X some people were vegans want to have no

03:4X animal products and all vitamin d3 is

03:4X made from animal products or almost all

03:4X there is a power plant source vitamin d3

03:5X but the vegans often want to go with a

03:5X d2 the liver converts vitamin d3 to – – –

03:5X hydroxy vitamin d3 by adding a hydroxyl

04:0X group and this is what is measured when

04:0X you go to the doctor's office and wonder

04:0X what your your blood level of vitamin D

04:1X is the half-life of this 25 hydroxy

04:1X Vaadin D is about two and a half

04:1X weeks now a kidney converts the 25

04:2X hydroxy body to 125 diet dihydroxy of

04:2X vitamin D and this this and the

04:3X parathyroid hormone PTH helped keep

04:3X serum calcium within a tight range the

04:3X 125 increases calcium absorption from

04:4X the intestines whereas a PTH increases

04:4X calcium absorption from the bones so we

04:4X have sort of a push and pull and so it's

04:4X there's not a direct correlation between

04:5X the amount of 25 and 125 but the more 25

04:5X you have the more 125 you can make there

05:0X are other actions of vitamin D and

05:0X that's what I primarily study most of

05:0X the action of vitamin D is through the

05:0X 125 entering the vine D receptors which

05:1X are coupled to chromosomes in there

05:1X every cell of the body when activated

05:1X the VTR's control the expression of many

05:2X genes up regulating most of them down

05:2X regulating others and it turns out that

05:2X not only a kidney can convert the 25 to

05:2X 125 but also other organs as needed

05:3X so for example you cancer someplace the

05:3X cells in that organ can also convert the

05:3X 25 to 125 and the skin it can convert 25

05:4X to 125 now Von D also fights bacterial

05:4X and some viral infections by inducing

05:5X production of Catholics seitan that's

05:5X the polypeptide with antimicrobial and

05:5X anti endotoxin properties fine B also

05:5X induces reduces inflammation by reducing

06:0X a production of pro-inflammatory

06:0X cytokines which are chemical messengers

06:0X to underscore the importance of vitamin

06:1X D for human health I note that skin

06:1X pigmentation varies globally depending

06:1X on where people live for hundreds to

06:1X thousands of years for example the the

06:2X Aborigines in Australia are very

06:2X dark-skinned their ancestors were from

06:2X the force of the Indonesia where

06:2X where they were brown-skinned but when

06:3X they got to Australia with no trees to

06:3X cover them they needed a very dark skin

06:3X to protect them from the very very

06:3X intense UV so dark skin in the tropics

06:4X reduces the risk of free radical

06:4X formation and skin cancer as well as

06:4X protecting against folate destruction

06:4X and folate is very important for

06:5X pregnancy and for pregnancy now as

06:5X humans moved out of Africa started

06:5X moving in northward they had to develop

07:0X lighter skin in order to make enough

07:0X vitamin D from the from the less intense

07:0X UV and they didn't need the protection

07:0X of the dark pigment against the free

07:1X radicals and full of destruction what

07:1X would happen they would get more

07:1X infectious diseases like tuberculosis

07:1X they would also get more rickets and

07:2X poor bone formation and so then the

07:2X pelvic cavity wouldn't be large enough

07:2X to let a feed on an infant come out in

07:2X the birth process and they hadn't

07:3X invented c-sections thousands of years

07:3X ago now Nina Jablonski and George

07:3X Chaplin and made a career out of going

07:4X around the world and measuring the un--

07:4X UV exposed pigment in many peoples

07:4X around the world and they have this

07:5X developed this map of skin pigmentation

07:5X they see very dark in the tropics where

07:5X you have no trees brown lighter color in

08:0X the tropical forest and very light in

08:0X the high latitudes so now let's go to

08:0X recommendations which I gave a talk in

08:1X Hungary last month and after I gave all

08:1X the information about what the benefits

08:1X are all I wanted to know was well how

08:1X much do I need how much should i what

08:1X should my level be so in 2011 the

08:2X Institute of Medicine announced that

08:2X adults up to the age of 7 years old

08:2X should have 600 ru per day over 70 years

08:3X they should have editor ru per day and

08:3X that 20 nanograms per milliliter vitamin

08:3X D concentration was 25 hydroxy vitamin E concentration

08:4X was just fine well it turns out that

08:4X that was a not a very sound study first

08:5X of all they were this was funded by the

08:5X Food and Drug Administration and the

08:5X National assistive health and Health

08:5X Canada and the two US organizations

09:0X worked very closely with Big Pharma and

09:0X also one of the organizers one of the

09:0X people on the committee had planned

09:1X another major vitamin E clinical trial

09:1X where people could take we're gonna take

09:1X 2000 IU of vitamin D per day in the

09:1X treatment arm but they got all my in the

09:2X treatment or the control arm could take

09:2X as much as the Institute of Medicine

09:2X recommended so in order not to sabotage

09:2X her clinical trial she pushed I think

09:3X very hard for these recommendations but

09:3X in order to reach these recommendations

09:3X they did three things which which are

09:3X not very scientific

09:4X first of all they ignored all non

09:4X skeletal effects they ignored cancer

09:4X cardiovascular disease autoimmune

09:4X diseases respiratory infections etc

09:4X second they demanded published

09:5X randomized controlled clinical trials of

09:5X a vitamin D and at a time when they did

09:5X a study all I could point to was

10:0X clinical trials for bone health

10:0X the third thing they did was they took a

10:0X study from Germany which looked at

10:0X people who died in automobile accidents

10:1X so they're healthy people just happen to

10:1X die prematurely and in the study they

10:1X they looked at the osteoid amount of the

10:2X bones noted as the unn mineralized

10:2X calcium in the bones sort of liquid or

10:2X gelatin life and they also compared the

10:3X 25 hydroxy vitamin D concentrations with

10:3X with the amount of this poor bone

10:3X mineralization and what they did was

10:3X they ignored the findings between 20 and

10:4X 30 nanograms in terms of they still had

10:4X a few at that point who had on

10:4X mineralized bone but they said that

10:5X wasn't important that most of the people

10:5X with underlies bone were below 20

10:5X nanograms so we're gonna stick with 20

10:5X he has been shown in many comments later

11:0X on that that was a major mistake and I

11:0X think the Institute of Medicine now

11:0X realizes that yeah but it took quite a

11:0X few years then I realized that now in

11:0X 2011 The Endocrine Society led by

11:1X Michael Holick team led by Michael

11:1X Holick published a recommendation for

11:1X dealing with a vitamin D deficiency now

11:1X it's the first one the Institute of

11:2X Medicine was for the general public healthy or not

11:2X the endocrine Society was dealing with

11:2X with people being treated by doctors

11:2X fortified in D deficiency so they

11:3X recommended a 1000 2000 IU per day of

11:3X item d2 or d3 and a serum vitamin e

11:3X concentration of around 30 nano grams

11:4X per milliliter at least they considered

11:4X 20 deficient between 20 and 30

11:4X insufficient above 30 sufficient however

11:5X there are finally advocacy organizations

11:5X which I'll name at the end who have

11:5X looked carefully at the the general

11:5X literature that comes out on a daily and

12:0X a weekly basis and have some of these

12:0X people have written peer-reviewed papers

12:0X on the benefits of item D and they've

12:0X looked at people with higher

12:1X concentrations and and how much better

12:1X they do in terms of athletic performance

12:1X or lack of disease and they're

12:1X recommending around 2,000 to 5,000 IU

12:2X per day vitamin d3 not skipping vitamin

12:2X d2 and a serum concentration of around

12:2X 40 to 60 nano grams per milliliter

12:2X one of the reasons for saying 40 to 60

12:3X is that looking at healthy Africans

12:3X modern-day Africans who are outdoors

12:3X every day with dark skin with with some

12:4X clothing I mean they're not not just

12:4X annoying Clause but they have a fair

12:4X amount of clothing on they have around

12:4X forty five nanograms per milliliter

12:5X serum 25 hydroxy vitamin D and so you

12:5X have these three recommendations so well

13:0X now just to show a picture here

13:0X Roger bouillon on the on the left is one

13:0X of the most prominent finally

13:0X researchers in Europe believe he's in

13:1X Belgium he's a lot of European leaders

13:1X are the 20 nanograms per milliliter camp

13:2X Michael Holick on the other hand is the

13:2X leader of the 13 anagram plus camp now

13:2X there are three sources of vitamin D the

13:3X sunlight is the primary source this map

13:3X this is a shows on the bottom is a month

13:4X of the year from from January through

13:4X December along the y-axis you have the

13:4X latitude from zero the tropics up to 90

13:5X degrees at the top and the colors

13:5X indicate how much time you have to be in

14:0X the Sun in order to make I see how much

14:0X well let's see if you okay if it's red

14:1X you cannot make any vitamin D if it's in

14:1X the blue the purple range you can make

14:2X some vitamin E it's gonna take longer

14:2X like maybe up to half an hour an hour to

14:2X be in the Sun and if it's black you can

14:2X make it fairly easily so we're about 30

14:3X degrees north latitude here so in the

14:3X winter we have a difficult time making

14:3X vitamin D but by March or April through

14:4X about October we can make a fair amount

14:4X of vitamin D and this this map was 400 – -

14:4X IU of a per day of vitamin D now if you

14:5X need 2,000 to 4,000 5,000 IU per day

14:5X this is the this scale would be changed

14:5X also it turns out that there's there's a

14:5X shadow rule the dermatologist like to

15:0X tell you if your shadow is shorter than

15:0X you are stay out of the Sun or cover up

15:0X or use sunscreen the vitamin E advocates

15:0X like to say unless your shadow is

15:1X shorter than you are you're not gonna

15:1X make much vitamin D so that means you

15:1X want to go out in your solar noon you

15:1X want to go out in the in the summer

15:1X spring summer and fall you want to

15:2X expose as much of your body as possible

15:2X you want to one of the reasons for going

15:2X out midday in addition is that the ratio

15:2X of UVA to UVB changes the shorter the

15:3X wavelength the more scattering there is

15:3X in the atmosphere and the way you can

15:3X tell that is the sky is blue and clouds

15:4X are orange so as a sunset sunrise the

15:4X Sun goes the sun rays go through a very

15:4X very large path and the shorter

15:4X wavelengths are scattering the

15:5X wavelengths much more rapidly than they

15:5X are the long wavelengths so the orange

15:5X gets to the clouds the blue gets to the

15:5X sky well UVB is much shorter than the

16:0X blue and so it's scattered even more in

16:0X fact even if you're under an umbrella

16:0X you're going to get UVB impinging on you

16:0X from the sides the the the the diffuse

16:1X scattering but the UVB the UVA is going

16:1X to be less scatter than UVB in fact UVB

16:1X is about three to five percent of total

16:2X UV and the rest is UVA

16:2X the problem with UVA is that it

16:2X penetrates the skin deeper and is more

16:2X important more responsible for melanoma

16:3X and basal cell carcinoma then UVB is so

16:3X if you went out morning evening you're

16:3X more likely to get melanoma but no

16:4X vitamin D so I was in a hungry last month

16:4X went over there ten conferences in

16:4X Warsaw and Thessaloniki and stopped off

16:5X in Budapest and found this this like a

16:5X porcupine with sign under saying Sun so

16:5X the Sun is one way to get your your your

17:0X vitamin D but you can also get it from a

17:0X solarium the indoor tanning booths maybe

17:0X have two to four percent UVB in the UV

17:1X if you go in for tanning you're going to

17:1X see how much longer they need to for

17:1X vitamin D production it turns out that

17:1X after you make that up to 20 thousand

17:1X international units of vitamin D from

17:2X whole body exposure in a Sun and half an

17:2X hour to an hour the body's that the UV

17:2X starts destroying the metabolites of

17:2X vitamin D so he can never make too much

17:3X vitamin D in the Sun now the other

17:3X sources of vitamin D are supplements and

17:3X diet and in terms of diet its animal

17:4X products like seafood but it turns out

17:4X that that a study in England found that

17:4X the people with the highest vitamin D

17:5X concentrations were not the fish eaters

17:5X it was the meat eaters the vegans had

17:5X the lowest amount the vegetarians a

17:5X little bit higher but there is about a

18:0X 1/8 nanogram per milliliter difference

18:0X between the meat eaters and the vegans

18:0X the reason is that meat has vitamin D as

18:0X 25 hydroxy vitamin D so most of the food

18:1X tables that talk about vitamin D do not

18:1X read do not include that in the study so

18:2X all these food frequency tables and how

18:2X much find here get from fewer eggs and

18:2X from your milk and so on they would find

18:2X about 250 to 300 IU per day in the American diet

18:3X not counting what's in a meat

18:3X and of course 250 and 300 are you per

18:3X day is not enough to to do much now

18:3X there are other effects of UV exposure

18:4X one thing you do is you get beta

18:4X endorphins which help reduce pain and

18:4X help you feel better

18:5X in fact the dermatologists realize that

18:5X people often go to tanning beds on a

18:5X regular basis because they get an

18:5X endorphin high and the claim is that

19:0X they're getting addicted to tanning

19:0X because of the beta endorphins mike my

19:0X thought is that anything that has

19:0X long-term benefits nature and sometimes

19:1X provides short-term benefits to make you

19:1X understand that their long-term benefits

19:1X and so I think there's a you know should

19:1X be applauded rather than criticize

19:2X another thing is you can release my

19:2X trick oxide subcutaneous nitrogen

19:2X compounds which can lead to lower blood

19:2X pressure in fact if you look at the

19:3X latitudinal distribution of blood

19:3X pressure it's lowest in the tropics and

19:3X highest in the high latitudes of course

19:3X that could also be related to dietary

19:3X factors but but it could be related to

19:3X some what - to UV there are some we'll

19:4X see multiple sclerosis has a very

19:4X pronounced latitudinal effect and four

19:4X years of thought that that was because

19:5X of vitamin D production but now both

19:5X human studies and and animal studies

19:5X have indicated that there are benefits

19:5X of UV aside from vitamin D production

20:0X that reduced the risk of multiple

20:0X sclerosis of course there are other

20:0X effects you can reset your biological

20:0X clock through the blue light around 420

20:1X nanometers I found out when I went to

20:1X say Sweden in February I was there for

20:1X two weeks and never got on Swedish time

20:1X and last month I was in in Warsaw for a

20:2X week and it rained every day and I did

20:2X not get on Warsaw time finally in in

20:2X Budapest I started with sunlight I start

20:2X to get over on the European time also

20:3X turns out that as I was so later than

20:3X just getting outside and exercising is

20:3X very beneficial and has health effects you

20:4X tentative of vitamin D so those most

20:4X likely to have low vitamin E

20:4X concentrations are those spending most

20:4X time indoors this will also include

20:5X those who have do shift work and sleep

20:5X during the day because they work at

20:5X night not being the Sun nurse solar noon

20:5X went with sufficient body surface

20:5X exposed dark-skinned people I'm working

21:0X on a manuscript on the health benefits

21:0X of vitamin D for dark-skinned people in

21:0X the United States we're going to Bruce

21:0X Ames on this and see if the average the

21:1X mean casa

21:1X 25 hydroxy vitamin d concentration for white

21:1X adult American Americans is around 21 ?

21:2X nanograms per milliliter of course our

21:2X seasonal variation is gonna be a factor

21:2X of 2 between summer and winter for

21:2X Hispanics is more like 21 nanograms and

21:3X for black Americans and more like 1 ?

21:3X nanograms so yeah in Africa they had all

21:4X the vitamin E they needed but not here

21:4X in the United States those who are

21:4X overweight or obese I generally have

21:4X much lower body concentrations than

21:4X those who are normal weight wearing

21:5X sunscreen or even wearing using skin

21:5X lightening cream reduces the vitamin E

21:5X production and it turns out older folks

22:0X over the age of 60 and perhaps even

22:0X little bit younger have less of the 7 d

22:0X high high low cholesterol in a thinner

22:0X skin that that is converted to two

22:1X vitamin D and salami didn't may need to

22:1X stay in the Sun two to three to four

22:1X times longer to make the same amount of

22:1X vitamin D so there are values of

22:2X measuring 25 hydroxy vitamin D and also

22:2X turns out that even if you take a

22:3X thousand or 2,000 I you if I marry per

22:3X day there's a large variation in the

22:3X response to to vitamin D some people may

22:4X make twice as much 25 from the same out

22:4X of oral vitamin D and turns out it

22:4X depends on whether you take it with a

22:5X large meal so it goes slow

22:5X intestines whether you're taking more

22:5X magnesium to help conversion 225 etc etc

22:5X so if you really want to know where your

23:0X your concentration is you really ought

23:0X to have your 25 hydroxy vitamin D

23:0X measured you can have your doctor do it

23:0X but you can also go to grassroots health

23:1X net or the Van Dien Council org and both

23:1X of them sell a blood spot kit and you

23:2X get a little Lance you draw three or

23:2X four spots of blood and put it on a card

23:2X there's dried blood just sent back to

23:2X them they they sent it to a laboratory

23:2X and they it's very accurate they use

23:3X Hema they use an average Hema crit value

23:3X for the entire population around well so

23:3X if your Hema crypt is somewhat different

23:4X from from normal that might be a slight

23:4X error but I've checked it out some time

23:4X ago and when I was taking more like

23:4X $5,000 per day and I got 65 67 and 6 -?

23:5X nanograms per milliliter depending on

23:5X the blood spot test

23:5X and two of the wet chemistry labs so I

24:0X think they're quite a Qi accurate

24:0X grassroots health also has a program

24:0X where you can have your your 25 hydroxy

24:0X dividing measured every six months and

24:1X you're then entered into a scientific

24:1X study they want you to stay in it for

24:1X about five years they'll ever ask your

24:1X health question how's your health what

24:1X did you did you fall did you get sick

24:1X etc etc and they've actually used these

24:2X results in several peer-reviewed

24:2X publications so now we get into the

24:2X benefits why you really want vitamin D

24:3X I'm gonna skip bones because I really

24:3X haven't study bones that was sort of the

24:3X classical vitamin D area and it's been

24:3X the last almost two decades now that the

24:4X non skeletal effects have become very

24:4X important and that's what I've studied

24:4X so there's cancer there's respiratory

24:4X tract infections there's adverse

24:5X pregnancy and birth outcomes premature

24:5X death autism and ADHD dental caries poor

24:5X sleep cognitive dysfunction Alzheimer

25:0X disease erectile dysfunction and low testosterone

25:0X so there's said to be something for

25:0X everybody in here if not you your

25:0X children or your grandchildren so the

25:1X the first link between UV exposure and

25:1X lower risk of cancer was made by the

25:1X brothers cedric and frank garland who as

25:2X beginning graduate students at johns

25:2X hopkins school of public health and

25:2X knights en 74 saw a map something like

25:2X this it only had five color scales

25:3X instead of ten but they saw that there

25:3X was lower colon cancer in the southwest

25:3X in higher colon cancer in northeast they

25:3X just driven driven from Sandy Hill to

25:4X Maryland and then it was very sunny in

25:4X the southwest and not very sunny in the

25:4X Northeast so they hypothesized that

25:4X since the primary the

25:5X largest physiological effect of sunlight

25:5X is widen D production that bottom D must

25:5X reduce the risk of cancer well it took

26:0X them six years to get that paper

26:0X published and then it was an in a

26:0X British Journal which is finally finally

26:0X published in but nobody really took much

26:1X notice of it in 1985 they show that

26:1X dietary vitamin D was linked to low

26:1X cancer risk in 1989 they showed that low

26:2X serum 25 hydroxy vitamin is linked to

26:2X low colon cancer risk

26:2X they also extended this to breast cancer

26:2X and ovarian cancer somebody else did

26:3X prostate cancer and lymphoma but you can

26:3X understand that since no I was gonna get

26:3X rich selling vitamin D or selling

26:4X sunlight that the medical system had

26:4X just sort of said not much so I came

26:4X along in 1999 after doing some work

26:4X mentioned on on dietary factors and I

26:5X saw these new maps that were published

26:5X by the National Institutes of Health and

26:5X I saw all the read of the Northeast

27:0X except for prostate cancer was in the

27:0X northwest and I said gee maybe I can

27:0X explain this based on dietary factors

27:0X well I took two weeks to realize that we

27:1X eat the same food countrywide except in

27:1X the South would have Allah barbecue now

27:1X if you look at these you'll see very

27:1X similar patterns breast

27:1X again high mortality rates in the Northeast

27:2X but you have some also some high breast

27:2X cancer rates along the West Coast turns

27:2X out that along the coast you have more

27:2X clouds and fog and so people are not

27:3X getting as much UVB along the coast that

27:3X they were inland so breast cancer is not

27:3X quite as strong a link between UVB

27:3X Vaughn B and in reduced risk as colon

27:4X cancer for kidney cancer you'll see down

27:4X in Louisiana some hot spots that's

27:4X because of the chemicals in the chemical

27:5X manufacturing there stomach cancer you

27:5X sees a lot of red along the Mexican border

27:5X that's because of hygiene and much more

27:5X h pylori in among mexicans so we get

28:0X more stomach cancer prostate cancer is weird

28:0X you see the red now is shifted more to

28:0X the northwest and the blue more to the

28:1X southeast it turns out that both low and

28:1X high 25 hydroxy vitamin D have about the

28:1X equal risk for prostate cancer there's

28:2X some benefit of Von D in fighting

28:2X aggressive prostate cancer but it turns

28:2X out that that calcium is an important

28:3X risk factor for prostate cancer and

28:3X since one of the benefits of the effects

28:3X of vitamin D is to increase absorption

28:3X of calcium it could be that there's a

28:4X sort of a trade-off between having too

28:4X much vitamin D and inducing too much

28:4X calcium absorbtion that may play a role

28:5X here it's still being debated by the the

28:5X in the peer review literature I don't

28:5X have a definitive answer on that but so

28:5X what I did I got the NASA data for UVB

29:0X at the surface for July 1992 and you see

29:0X it's very asymmetrical the the highest

29:1X rates are in the southwest Arizona New

29:1X Mexico the lowest rates are northeast

29:1X and the reason you have higher UVB in

29:1X the west and an East is that the surface

29:1X elevation tends to be higher we have

29:2X more mountains and and even the arm like

29:2X the Nevada desert is higher than

29:2X then than a sea level and then you have

29:2X the westerly winds have to cross the

29:3X Rocky Mountains and in doing so they

29:3X pushed the tropopause higher and make

29:3X the stratospheric ozone layer thinner

29:3X and it's the ozone in the stratosphere

29:3X that blocks the UVB so you have less

29:4X absorption unless scattering in the

29:4X atmosphere so you have more UVB here in

29:4X the east you also have more clouds and

29:5X aerosols which is not reflected in this

29:5X map but but also plays a role so from

29:5X ecological studies we found about 15 to

30:0X 20 types of cancer that are reduced from

30:0X UVB exposure and we think and we have

30:1X evidence for a lot of these that higher

30:1X 25 hydroxy vine D levels are correlated

30:1X with lower cancer risk

30:1X so either incidence or mortality rates

30:2X so it's colon esophageal laryngeal oral

30:2X pharyngeal rectal small intestine the

30:2X female cancers breast in the material

30:3X ovarian and Evolver urogenital bladder

30:3X kidney prostate and testicular

30:3X miscellaneous organs gallbladder lung

30:3X pancreatic and thyroid and the blood

30:4X cancers lymphoma leukemia non-hodgkins lymphoma

30:4X now how much vitamin what's the

30:5X correlation between 25 hydroxy vitamin D

30:5X and cancer incidence well I made this is

30:5X sort of a graphical meta-analysis now

31:0X I've taken 11 studies from seven

31:0X countries and merge them together by

31:1X adjusting the the odds ratio with

31:1X respect to the 25 hydroxy Von D so

31:1X they're all laying the same line and now

31:2X the units here are Nana moles per liter

31:2X you divide by 2.5 to get nanograms per

31:2X milliliter so what you see is below

31:2X about 20 nanograms you get a steep rise

31:3X in the risk and when you get out to

31:3X about 40 nano grams you still have some

31:3X reduced risk but you're slowing down

31:4X the the the the increase the reduction

31:4X in odds ratio the the dash dash lines

31:5X and outside shield a 95% confidence

31:5X intervals there was this is the

31:5X uncertainty from the measurements

32:0X I mean sorry we have a this slope like

32:0X this and this seems to be typical for

32:0X other health outcomes as well although

32:0X for some diseases you may be a threshold

32:1X at twenty or thirty nanograms more than

32:1X forty or fifty nanograms like for cancer

32:1X and now we have results from this was a

32:2X recent clinical trial conducted into

32:2X Nebraska with postmenopausal women with

32:2X an average BMI of about 31 and a

32:3X baseline 25 hydroxy vitamin D of around

32:3X 33 nanograms

32:4X body mass index BMI so these were obese

32:4X people on average with high 25 hydroxy

32:4X but indeed there were about a I think

32:5X was a thousand women involved for four

32:5X years and they were given $2,000 per day

33:0X plus about a gram of calcium or placebo

33:0X or yeah or placebo and it turns out that

33:1X in the clinical trial in the

33:1X intention-to-treat they had one more

33:1X cancer case in the treatment arm then

33:1X then would be the case if they had less

33:2X than a one in 20 chance that this was a

33:2X an effect found by chance there was a P

33:2X was less P was 0.06 instead of 0.05 and

33:3X so when the papers published JAMA said

33:3X on news release saying clinical trial

33:3X shows that vitamin D does not

33:3X significantly reduce the risk of cancer

33:4X but the people at Creighton University

33:4X along with with people from grassroots

33:4X health and Keith beggarly said now wait

33:4X a minute if we look at the serum 2X 33:5X hydroxy of

33:5X the most the most recent measurement

33:5X before they developed cancer we find

33:5X that those that had between 40 and and

34:0X 80 nanograms per milliliter has

34:0X significantly reduced risk of cancer

34:0X compared to those with less than 4 -“

34:1X nanograms familiar but since they have

34:1X not specified this as an outcome in the

34:1X protocol JAMA made them put it in the

34:1X online appendix the supplementary files

34:2X which was not seen by most people

34:2X Creighton University however issued a

34:2X press release saying see we found a

34:2X benefit and so we had the two competing

34:3X press releases and that who have people

34:3X saw both were a little confused for

34:3X cardiovascular disease here's another

34:3X observational study meta-analysis

34:4X showing that below 20 nanograms per

34:4X milliliter there's an increased risk of

34:4X cardiovascular disease unfortunately

34:4X there have been no clinical trials that

34:5X have confirmed that giving people

34:5X vitamin D and reduce the risk of

34:5X cardiovascular disease so the question

34:5X is is this maybe because they are out of

35:0X doors more maybe they're exercising more

35:0X out of doors maybe they're eating

35:0X different diet or is there vitamin D

35:0X maybe it's a long-term vitamin D effect

35:1X and if you do a two to four year study

35:1X you don't find the effect so this is

35:1X still sort of up in the air about

35:1X cardiovascular disease seasonal

35:2X influenza dr. John Connell who runs the

35:2X vitamin D council proposed in 2006 that

35:2X influenza was largely seasonal due to

35:3X seasonal variations and UVB doses he had

35:3X been given being giving his he worked at

35:3X a task Adaro hospital for the clinically

35:3X insane he'd been giving his patients

35:4X 5000 IU per day and in 2004-2005 when an

35:4X influenza epidemic came through the area

35:4X his patients were largely spared so they

35:5X got him thinking about well maybe

35:5X vitamin D does reduce the risk of

35:5X influenza in fact shortly after his

35:5X papers published the results of a

36:0X clinical trial involving postmenopausal

36:0X women in Long Island was was reanalyzed

36:0X and they found that indeed those taking

36:0X $2,000 per day had very few influenza or

36:1X cold events whereas those taking 800 had

36:1X several and those taking 400 are you had

36:1X quite a few so that was one clinical

36:1X trial that that showed that yes finally

36:2X done reduce did reduce the risk of

36:2X influenza and then a one involving

36:2X Japanese school children show that it

36:2X reduced type a but not type B influenza

36:2X I might add that cold temperature and

36:3X low humidity also in contribute to the

36:3X seasonality because the influenza virus

36:3X lives better in a cold dry environment

36:4X so that's why it can be passed from

36:4X person to person in the winter but on

36:4X the other hand it's the volunteers can

36:4X help you induce Catholic sidon to fight

36:4X the influenza pregnancy clinical trials

36:5X in South Carolina found that pregnant

36:5X women have better pregnancy and birth

36:5X outcomes by taking 4060 400 IU per day

36:5X of 1 D 3 and reaching 40 nanograms per

37:0X milliliter 25 for dr. c ymd the reason

37:0X is that above 40 nanograms

37:0X the 125 dihydroxy of vitamin D

37:1X concentration is stabilized

37:1X leaving to improve gene expression and

37:1X there's ever a period of life when gene

37:1X expressions important is during the

37:2X fetal development period so the benefits

37:2X of IMD during pregnancy includes reduced

37:2X risk of primary c-section delivery on

37:2X c-section delivery

37:2X well vaginal delivery is important to

37:3X give the the infant the the gut biome it

37:3X needs to to get off to healthy immune

37:3X start reduced risk of gestational

37:3X diabetes reduce risk of preterm birth

37:4X and for the infants reduced risk of low

37:4X for gestational weight reduced risk of

37:4X autism and reduced risk of asthma this

37:5X is from the studies in South Carolina

37:5X and it's showing that below below twenty

37:5X six point five nanograms per milliliter

37:5X there's a reduction in the gestational

38:0X age above that there seems to be a

38:0X plateau so here's another benchmark for

38:0X pregnant women in terms of overall age

38:1X adjusted mortality rate standard Garlin

38:1X and company advertised

38:1X analyzed 32 observational studies and

38:2X found that it took 36 nanograms per

38:2X milliliter before the mortality rates

38:3X plateaued and you see there's a pretty

38:3X much a linear rise to twice the

38:3X mortality rate at lower local of 1 -?

38:4X nanograms familiar as adult mortality so

38:4X I've done my own analysis where I looked

38:5X at disease rates in in various countries

38:5X and the observational studies for the

38:5X relationship between 25 hydroxy body and

39:0X the incidence or mortality rate and

39:0X found that if everyone well the global

39:0X average 25 hydroxy varney is around 2 -?

39:1X nanograms it turns out because of skin

39:1X pigmentation varying no matter whether

39:1X you where you live the population

39:1X average is around 22 nanograms unless

39:1X you're in the Middle Eastern country and

39:2X where to any close then it's gonna be

39:2X lower if you're african-american it's

39:2X gonna be lower and so on but anyway if

39:2X you increase from 22 to 44 nanograms it

39:3X appears that the vitamin d sensitive

39:3X mortality rate would reduce by about 2 -? percent

39:3X and that's accounts for about half of a

39:3X and the deaths and so this would lead to

39:4X a life expectancy increase in about two years

39:4X athletic performance again John Cornell

39:4X wrote a paper I think into 2009 and he

39:5X went through a number of reasons why he

39:5X thought that there'd be better athletic

39:5X performance for one thing he point out

39:5X that the Mexican Olympics 1968 had a lot

40:0X of World Records and a lot of people had

40:0X gone there to to practice before had to

40:0X get used to the altitude he thought it

40:0X was not the altitude but the UVB and the

40:1X vitamin D so he published this 2009 in a

40:1X sports medicine journal and as a result

40:1X the Chicago Blackhawks became the first

40:2X vitamin team in modern professional

40:2X sports became the first time the team in

40:2X modern professional sports history and

40:2X according to John sources the Black Hawk

40:3X team physician became began diagnosing and treating

40:3X finding efficiency in all blackhawk

40:3X players about 18 months ago written in

40:3X 2010 and apparently most players were

40:4X taking 5,000 IU per day after losing

40:4X many seasons last year the Blackhawks

40:4X came out of nowhere to get the Western

40:4X Conference Finals

40:4X this year they're playing even better so

40:5X one thing is going to do is reduce their

40:5X risk of influenza and Kohl's and all

40:5X sorts of other respiratory infections

40:5X the other thing is going to do is reduce

40:5X the risk of stress fractures another

41:0X thing a faster healing of wounds so very

41:0X important

41:0X Don and I to John also wrote the first

41:1X paper on vitamin D and the risk of

41:1X autism I worked with him in 2013 we got

41:1X the Provost data for children ages 6 to

41:2X 17 years as a function of state I looked

41:2X at those versus UVB doses in the summer

41:2X for the well actually of October and

41:2X found that there was an inverse

41:3X correlation between UVB and risk of

41:3X autism it turns out that African

41:3X Americans have higher rates of autism

41:3X than white Americans their darker skin

41:4X making less vitamin D and there are

41:4X mechanisms to explain why find D

41:4X deficiency in both in in in utero and

41:5X early life would lead to increased risk

41:5X of autism ADHD it has a pattern which

42:0X you see the lower rates in the Southwest

42:0X higher rates in the east and northeast

42:0X again as sort of looks like the UVB

42:1X inverse of UVB dental carries it turns

42:1X out that there were data from the 20s

42:1X 30s and 40s if I plotted the the the

42:2X dental health rank versus UVB dose you

42:2X see that below about 6.5 kilojoules per

42:3X meter squared there was a linear slope

42:3X upwards and above that there was a

42:3X plateau in fact even a paper from 186 -?

42:3X showed that if you looked at the Union

42:4X Army soldiers those from Maine and New

42:4X Hampshire had lost quite a few teeth

42:4X why time you got to Kentucky or so they

42:4X had most of T still intact so even then

42:5X there was an effect of UV on dental health

42:5X in fact the first clinical trial on

42:5X vitamin D was for children in England in

43:0X 1928 giving them body and looking at

43:0X dental caries and they found that yes

43:0X they reduce the risk of dental caries

43:0X and the woman doing this study said that

43:1X the bacteria were dead

43:1X she didn't know why but we know why now

43:1X and this here shows that that there were

43:1X a number of studies never clinical

43:2X trials in the 30s and 40s

43:2X we showed a 50% reduction in dental

43:2X caries for children taking a vitamin

43:2X game sleep turns out that raising 2 -?

43:3X hydroxido into 60 to 70 grams per

43:3X milliliter does improve sleep however

43:3X the women doctor gummy enact doing this

43:3X study found that after two years the

43:4X people who started reporting systemic

43:4X pain one of her patients helped her

43:4X realize that it was because they were

43:5X becoming a vitamin D vitamin B deficient

43:5X the back gut bacteria producing finally

43:5X when you sleep you restore the body

43:5X through methylation and methylation

43:5X requires B vitamins and so they're using

44:0X up some of the vitamins in the gut and

44:0X when she gave them be 104 which has the

44:0X multiple beef in a couple months they

44:0X got the gut back in shape and pain went

44:1X away and they were fine there's also

44:1X fine the verbal fluency cognitive decline

44:1X there's Alzheimer's disease and dementia

44:2X this looks like below 20 nanograms

44:2X there's a problem erectile dysfunction

44:2X below 20 nanograms per milliliter

44:3X testosterone there's a study involving

44:3X obese people in Austria and they found

44:3X that by giving them vitamin D they did

44:3X increase their testosterone in fact I've

44:4X myself and two other men taking high

44:4X doses of vitamin D found that when they

44:4X were up around 60 or 70 nanograms per

44:4X milliliter that they got the

44:4X testosterone up so it's a in fact that

44:5X could help improve athletic performance

44:5X because testosterone helps muscles

44:5X surgery turns out that people who go

45:0X into surgery with higher 25 hydroxy

45:0X Vandy recover more quickly

45:0X wounds heal faster burns heal faster so

45:1X whereas widened D policy headed well we

45:1X have four or five or six major one D

45:1X supplementation trials which will

45:2X complete data collection this year next

45:2X year and then analyze the results they

45:2X generally use about 2000 IU per day or

45:3X $100,000 per month and these studies as

45:3X imperfect as they are will provide the

45:3X basis for the next recommendations I was

45:4X just in Warsaw this is a committee

45:4X reviewing posters by the mrs. Michael

45:4X Holick in front looking carefully at

45:4X that posters so I published a paper

45:5X recently saying why the clinical trial

45:5X should be based on vitamin D on 2 -?

45:5X hydroxy Von D because most the trials

46:0X are based on the assumptions used for

46:0X pharmaceutical drugs first of all that

46:0X the trial is a sole source of the agent

46:1X and second that there's a linear

46:1X dose-response relationship between the

46:1X agent and the health outcome

46:1X neither assumption is valid for vitamin

46:2X for vitamin D and also it turns out many

46:2X of the trials do not follow to measure

46:2X 25 hydroxy vitamin D they just you know

46:3X think you take the average healthy

46:3X person and so they get a healthy person

46:3X affect that there's no benefit of more

46:3X vitamin D here we show that from the

46:4X grassroots health data set that for

46:4X people taking any reporting that they're

46:4X taking any value of oral vitamin D that

46:5X there's about a 50 nanogram spread plus

46:5X or minus 15 intagram of the 25 hydroxy

46:5X vitamin D concentration that's why if

46:5X you really wanna know what your vitamin

47:0X E level is you gotta have it measured it

47:0X turns out that why do we need clinical

47:0X trials well observational studies could be

47:1X being using the 25 hydroxy of any

47:1X concentration as an indent of diet or of

47:1X UVB exposure it turns out for example

47:2X that meat consumption increases

47:2X literally from the from the tropics

47:2X highest consumption racer and the high

47:2X latitudes if you have mechanisms you

47:3X don't know how much how important Von D

47:3X is in reducing risk the health systems

47:3X most of clinical trials as a gold

47:3X standard we're now in the evidence-based

47:3X medicine

47:3X era as imperfect as it is but they're

47:4X trying in Budapest there's a lot of meat

47:4X being sold and so they get to increase

47:4X the risk of cancer and alt and

47:5X Alzheimer's disease but they're getting

47:5X some vitamin D so it's a bit of a

47:5X trade-off so anyway we're proposing that

47:5X all these trials be based on 25 hydroxy

48:0X Von D including the imaging beforehand

48:0X choosing the participants give enough

48:0X item D to raise 5 D levels high

48:0X measuring ans cetera et cetera

48:1X now why you've never heard about the

48:1X whole truth about vitamin D this is from

48:1X natural news.com well there's the

48:1X Federal Trade Commission that tells

48:2X tanning companies they cannot advertise

48:2X that tanning produces vitamin D big

48:2X pharma see is that as competition komen

48:3X Race for the Cure they don't want to

48:3X cure there they don't want to prevent

48:3X breast cancer they want to manage for

48:3X breast cancer the FDA they help sponsor

48:3X the Institute of Medicine report there's

48:4X oncologists who make fifty thousand

48:4X hundred thousand dollars in treating

48:4X cancer ten dollars a year for vitamin E

48:4X to prevent cancer no you don't want that

48:5X and the National Cancer Institute

48:5X so grassroots well okay I'm a co-author

48:5X on a book coming out shortly called

49:0X embrace the Sun mark Sorenson is the

49:0X primary author and dr. T who spoken here

49:0X before is doing a very careful text

49:0X editing Michael Holick wrote the

49:1X foreword for this this should be

49:1X available in November or December and

49:1X you can contact me and we can tell you

49:1X how to get it now for more information go to

49:2X med which has 27 million health

49:2X publications listed there you can

49:3X finally access with scholar.google.com

49:4X who spends all his waking hours making

49:4X bundy information accessible finding

49:4X counsel in nevada new society a society in cancer

49:5X thank you okay great thank you it's

49:5X really refreshing to hear someone talk

49:5X about being in the sun is it really good for you

50:0X we're gonna push a little bit beyond

50:0X where we would normally try to stop i

50:0X want to take a couple of questions if we

50:0X have them and then we need to start then

50:1X we can continue yeah after the

50:1X informally so any question i'm for the

50:1X group here right doesn't heal per day

50:2X but what are the consequences well the

50:2X primary consequence of too much of

50:2X vitamin D is hypercalcemia if you get

50:3X hypercalcemia you don't feel good and so

50:3X these people are taking fifty thousand

50:3X definitely feel fine they do have very

50:4X high 25 hydroxy Von D concentrations I

50:4X guess we'll just have to see what happens

50:4X it stores though the same 50,000 a year

50:5X saying but if you took it yeah if you

50:5X took it once a week or hmm

50:5X yeah the vitamin E can store in the fat

51:0X and the muscles the 25 has a short

51:0X half-life I'm hoping you would ask a

51:0X question first of all thank you for your

51:1X contributions to the scientific

51:1X community second of all so I have my

51:1X understanding is UVB is the best from 1 -?

51:1X a.m. to 4 p.m. and what would you

51:2X recommend like 20 to 25 minutes in the

51:2X sunlight well more like 10 to – ?

51:2X and it depends on how much skin you can

51:3X expose and your skin pigmentation so if

51:3X you're fair-skinned and mixed pros let's

51:3X say a young person exposing 10% of his

51:4X body can maybe make after you 20 or 30 I

51:4X you per per minute maybe so maybe 25 to

51:4X 15 minutes for a young person it might

51:5X be enough but if you can expose a

51:5X quarter of your body that's better you

51:5X cut down the time there are there are

51:5X UVB meters out that tell you how much

52:0X time you has been made thank you I'll

52:0X check that out okay one more quick okay

52:0X so that's Daly but if you only get out

52:1X once a week but you're out for six to

52:1X ten hours and the half-life is long

52:1X enough you can get enough that way also

52:1X correct yeah you can make twenty

52:2X thousand in a day so and you can store

52:2X the X and the half-life is two and a

52:2X half weeks and you can store the excess

52:2X vitamin D so that would probably do okay

52:3X that's good do you mind go ahead and ask

52:3X your question one on one or the one

52:4X where the people are taking and then

52:4X they're measuring the dosages about four

52:4X from the end or so is that published

52:4X somewhere that seems like a really

52:5X important okay we'll go ahead why don't

53:0X you go ahead and finish this one yeah

53:0X let's complete the evening thank you all

53:0X for coming we meet the third Thursday of

53:1X every month you