Photodermatol Photoimmunol Photomed. 2016 Mar 23. doi: 10.1111/phpp.12241. [Epub ahead of print]
Upala S1,2, Sanguankeo A1,2.
1Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, N.Y, USA.
2Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Vitamin D deficiency is associated with a number of autoimmune diseases. We completed a meta-analysis of observational studies to establish whether there was a relationship between hypovitaminosis D and the autoimmune skin disease vitiligo.
Comprehensive search was applied in the MEDLINE and EMBASE databases from their inception to December 2015. Inclusion criteria were observational studies that assessed 25-hydroxyvitamin D (25(OH)D) levels in adults with vitiligo. The main outcome was the mean difference in serum 25(OH)D level between patients with vitiligo and controls.
Our search strategy identified 383 articles; seventeen studies met the criteria for full-length review and seven studies, containing the data of 1,200 patients, were included in a random-effects model meta-analysis. The pooled mean difference in serum 25-hydroxyvitamin D concentration between patients with vitiligo and controls was -7.45 ng/mL (95% confidence interval, -12.99 to -1.91, P-value=0.01). The between-study heterogeneity (I2 ) was 96%, P=value<0.001.
This meta-analysis identifies a significant relationship between low 25-hydroxyvitamin D levels and vitiligo, but does not prove causation. Our findings emphasize the importance of measuring 25-hydroxyvitamin D levels in patients with vitiligo. Further studies will be needed to establish whether vitamin D supplementation in this population improves the outcome of vitiligo. This article is protected by copyright. All rights reserved.
- Vitiligo (spotty skin coloring) is 4 X more likely if poor Vitamin D Receptor – meta-analysis July 2018
- Vitiligo (loss of skin pigment) treated by narrowband UVB
- 35,000 IU vitamin D daily for 6 months helped ALL psoriasis suffers (106 ng) – Brazil March 2013
Many Vitiligo patients helped by Vitamin D - including oral, topical, and injection
- Skin whitening cream (RD) may cause blotchy skin, 5,000 Vitamin D can treat it – RCT Feb 2018
Two out of 16 vitiligo patients showed no repigmentation of the affected areas;
four patients showed 1–25% repigmentation,
five patients showed 26–50% repigmentation,
five patients showed 51–75% repigmentation and
none showed more than 75% repigmentation of the affected areas
- Investigation of vitamin D levels in patients with vitiligo vulgaris 2014
"25 patients with vitiligo vulgaris and in 41 controls."
The mean levels of vitamin D in patient 15 ng and the control group 14 ng
"There was no significant difference in vitamin D levels between patients who had family history of vitiligo (5 patients, 20%) and those that did not. "