Anti-inflammatory effects of vitamin D and resistance training in men with type 2 diabetes mellitus and vitamin D deficiency: a randomized, double-blinded, placebo-controlled clinical trial
Journal of Diabetes & Metabolic Disorders, pp 1–9 https://doi.org/10.1007/s40200-019-00416-z
Ali Dadrass Khalid Mohamadzadeh Salamat Email author Kamaladdin Hamidi Kamal Azizbeigi
Lots of Vitamin D benefit is often found when Vitamin D levels get >30 ng
In this study 50,000 IU of vitamin D failed to get >30 ng in 12 weeks
There are 8 ways they could have had more success
Diabetics often have poor gut function
Any of many gut-friendly forms of Vitamin D would likely have had much more benefit
- Vitamin D fails to prevent Type 2 Diabetes (unaware of 8 proven ways) June 2019
- Diabetic inflammation reduced by Calcium and 50,000 IU of vitamin D in 8 weeks – RCT
- Inflammation is reduced by each of the following: Vitamin D, Omega-3, Diet
- How Vitamin D reduces inflammation, improves immunity and fights autoimmunity – review Dec 2018
Overview Diabetes and vitamin D contains the following
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on
- All items in category Diabetes and Vitamin D
426 items: both Type 1 and Type 2
Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- Appears that Calcium and Magnesium are needed for both Prevention and Treatment
which are just some of the vitamin D cofactors
Objectives: The present study aimed to investigate the anti-inflammatory effects of vitamin D and resistance training in men with type 2 diabetes mellitus and vitamin D deficiency.
Design: This study was a randomized, placebo-controlled, double-blinded clinical trial.
Trial registration code: IRCT20190204042621N1
Forty-eight patients with type 2 diabetes aged 40–65 (from a total of 52 volunteers in Ardabil diabetes clinic) were randomly assigned to either the vitamin D supplementation with resistance training group (VD + RT: n = 12), the resistance training group (RT: n = 12), the vitamin D supplementation group (VD: n = 12), or the control group (CON: n = 12).
The subjects in VD group took vitamin D supplements at 50000 IU per 2 weeks for 3 months; the subjects in RT group exercised 3 times per week for 12 weeks; and the subjects in VD + RT group participated in both treatments. Subjects in CON group were asked to maintain normal daily life pattern for the duration of the study.
Serum Interleukin-6 (IL-6), Tumor Necrosis Factor-alpha (TNF-α) and C-reactive protein (CRP) levels were determined at pre and post-test and the data were compared among the four groups and between two tests (4 × 2) using two-way ANOVA with repeated measures.
- IL-6 decreased significantly (P = 0.001) in all groups (
- VD + RT = % -71.73,
- RT = % -65.85,
- VD = % -61.70).
- TNF-α decreased significantly (P = 0.001) in VD + RT (% -44.90) and RT (% -40) groups.
- CRP showed no significant change in any group (P > 0.05).
Results demonstrated that vitamin D supplementation in addition to resistance training had positive effects on some inflammatory markers in T2D and vitamin D deficient men. Vitamin D supplementation was especially effective when it was complemented with exercise training.
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