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Time-release of Vitamin D near bone - Dec 2021

Enteric Coated Oral Delivery of Hydroxyapatite Nanoparticle for Modified Release Vitamin D3 Formulation

Journal of Nanomaterials Vol 2021, Article ID 9972475, 9 pages https://doi.org/10.1155/2021/9972475
Ranga K. Dissanayake rangad at sjp.ac.lk 7 K. D. C. Perera,2 W. P. T. D. Perera ,2 W. P. S. L. Wijesinghe,2
and Janitha M. Unagolla3

  • 1 Department of Pharmacy and Pharmaceutical Sciences, Faculty of Allied Health Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda 10250, Sri Lanka
  • 2 Sri Lanka Institute of Nanotechnology, Nanotechnology and Science Park, Mahenwatte, Pitipana, Homagama 10206, Sri Lanka 3Department of Bioengineering, College of Engineering, University of Toledo, Toledo, OH 43607, USA


Vitamin D3 (VD) and calcium phosphate play a vital role in bone homeostasis. Factors such as obesity or gastrointestinal problems can render the use of pure VD and calcium phosphate supplements ineffective. This study investigated the possibility of using VD-loaded hydroxyapatite nanoparticles for the codelivery of VD and Ca3(PO4)2. Due to the high affinity of Ca3(PO4)2 for bone tissue, HA is an ideal delivery system to deliver VD to target tissue. Herein, HA nanoparticles were synthesized and loaded with VD using a vacuum evaporation method. The synthesized HA-VD nanoparticles were morphologically and chemically characterized by SEM, FTIR, and TGA. The system exhibited a two-stage release pattern, which includes a first-day burst release (35%) and sustained release for a further ten days. The cytocompatibility and cell penetrative ability of the nanoparticle system were assessed in vitro using preosteoblast cells: the system is nontoxic and well-tolerated. Finally, the VD-loaded HA nanoparticles were coated with a gastroresistant polymer, hypromellose phtalate-55 (HP-55) in order to protect the pH-sensitive HA from degradation at lower pHs. A coaxial electrospray technique was employed to achieve this. In all, the tested HA-VD system is a viable alternative for codelivery of VD, Ca2+, and PO43- to their target tissues.

VitaminDWiki observations

This appears to release Vitamin D over the period of a week near the bones.
This gets around problems of vitamin D bioavailability due to poor gut, no gal bladder, and poor liver.
Do not know if this is commercially available
Nanoemulsion for of vitamin D applied topically or swished in the mouth has similar capabilities
Mucosal membranes (mouth, lungs, nose, intestines, etc) can activate Vitamin D – July 2020
Sublingual Vitamin D sometimes is better than tablet – April 2020

Topical Vitamin D contains

Topical is one of the many ways of increasing the vitamin D in your body
Topical is 2X to 50X more expensive than oral form
Topical is great for those who not want to swallow pillls nor fortifiy their food/drink with Vitamin D
Topical is one of the many gut-friendly forms of vitamin D (good bioavailability for those with poor guts
Topical is especially good form to apply directly to skin problems:
    - i.e. Psoriasis  Warts  Burns  Acne  Eczema  Wounds  (lasts about a day)
    The skin, like most tissues of the body, can fully-activate Vitamin D locally - no liver nor kidney needed.
Provides perhaps 100X higher concentration of Vitamin D to that portion than if same dose were taken orally
There were > 700 topical Vitamin D products on Amazon Aug, 2019
     Creams. oils, patches, nanoemulsions, etc.
Suspect that topical Vitamin D is best absorbed where the skin gets Vitamin D naturally
- - - face and hands vs the back or the inside of arms
Nanoemulsions can also be applied topically under the tongue and inhaled

Topical Vitamin D provides more benefits than oral sometimes - many studies

VitaminDWiki - Fast-acting forms of Vitamin D

Vitamin D going thru the gut takes about a day to become activated
Fast-acting Vitamin D takes about 4 hours to become activated
Fast-acting is needed for medical emergencies, treating cold, treating flu, etc,

  • Topical - cream, spray, oil on skin
  • Sublingual vitamin D
  • Mouth-wash - put powder of 50,000 IU capsules in 1/4 teaspoon of water
    Swallow when done - after a few minutes
    Alternately - use Nanoemulsion form as a mouthwash
  • Inhaled - via lungs
  • Semi-activated Vitamin D
    • is fast, but slight over-dosing might cause Calcium problems

VitaminDWiki pages with NANOEMULSION in title

This list is automatcially updated

Items found: 17
Title Modified
Vitamin D: liposomal and nanoemulsion forms - Chat-GPT Dec 2023 30 Dec, 2023
Nanoemulsion Vitamin D is faster and better - many studies 06 Oct, 2023
Fast responses to Vitamin D – loading dose, nanoemulsion and Calcifediol – April 2023 15 Apr, 2023
Nanoemulsion Vitamin D faster and better (paywall) – RCT Dec 2021 02 Dec, 2021
COVID-19 defeated 3x faster by 420,000 IU Vitamin D nanoemulsion – RCT Nov 12, 2020 21 Sep, 2021
COVID-19 outpatients getting Quercetin nanoemulsion had excellent outcomes (Q increased Vitamin D in cells) – RCT – June 2021 30 Jul, 2021
Nanoemulsion Vitamin D may be a substantially better form 02 Jun, 2021
COVID-19 inflammation extinguished by 60,000 IU of vitamin D nanoemulsion daily for a week – RCT May 2021 22 May, 2021
Inhaling Vitamin D nanoemulsion through nose gets lots more to the brain (mice) – July 2020 03 Aug, 2020
Vitamin D nanoemulsion, with comments on COVID-19 – June 2, 2020 04 Jun, 2020
Nanoemulsion vitamin D is again found to be the best liquid form (for rats in this case) – June 2019 20 Dec, 2019
Bioavailability of nanoemulsion formulations of Vitamin D3 – Nov 2019 20 Dec, 2019
Treat wounds, stop inflammation with nanoemulsion textile of Omega-3 and Resveratrol - Sept 2019 15 Aug, 2019
Vitamin D nanoemulsion etc. for fortification, pills, injections, topical and cancer – July 2019 18 Jul, 2019
Vitamin D nanoemulsion corrected deficiency and improved bones in 1 week (high dose in rats) – Jan 2019 05 Jan, 2019
Inhaled nanoemulsion of Vitamin D killed lung bacteria – Sept 2017 19 Apr, 2018
Nanoemulsions of vitamin D help reduce asthma markers in mice– Dec 2013 12 Dec, 2013

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Time-release of Vitamin D near bone - Dec 2021        
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