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Metabolic syndrome 1.9 X more likely if senior women had less than 30 ng of Vitamin D – Oct 2017

Vitamin D deficiency is associated with metabolic syndrome in postmenopausal women

Maturitas, online 18 October 2017, https://doi.org/10.1016/j.maturitas.2017.10.011
Eneida Boteon Schmitt, Jorge Nahas-Neto, Flavia Bueloni-Dias, Priscila Ferreira Poloni, Claudio Lera Orsatti, Eliana Aguiar Petri Nahas,


Highlights

  • Vitamin D deficiency and obesity are important public health issues.
  • Several studies of the general population have shown an inverse relationship between vitamin D levels and metabolic syndrome (MetS), diabetes and insulin resistance. However, data for postmenopausal women are sparse and contradictory.
  • We evaluated the association between vitamin D deficiency and metabolic syndrome in postmenopausal women.
  • Vitamin D deficiency in postmenopausal women was associated with a higher prevalence of metabolic syndrome.
  • Women with vitamin D deficiency had a higher risk of hypertriglyceridemia and low levels of high-density lipoprotein than those with adequate levels.

Objective: To evaluate the association between vitamin D (VD) deficiency and risk factors for metabolic syndrome (MetS) in postmenopausal women.

Study design: Observational, cross-sectional cohort study.

Main outcome measures
In this study, 463 women, aged 45-75 years, with amenorrhea >12 months, without VD supplementation or established cardiovascular disease were included. Clinical and anthropometric data were collected. Biochemical parameters, including total cholesterol (TC), HDL, LDL, triglycerides, glucose, insulin and 25-hydroxyvitamin-D [25(OH)D] were measured. Women meeting three or more of the following criteria were diagnosed with MetS: waist circumference >88 cm, triglycerides ≥150 mg/dL, HDL <50 mg/dL, blood pressure ≥130/85 mmHg and glucose ≥100 mg/dL. Serum 25(OH)D levels were classified as sufficient (≥30 ng/mL), insufficient (20–29 ng/mL) or deficient (< 20 ng/mL). ANOVA, chi-square test and logistic regression (odds ratio, OR) were used for statistical analysis.

Results
Serum 25(OH)D levels were sufficient in 148 women (32.0%), insufficient in 151 (32.6%) and deficient in 164 (35.4%). Women with low 25(OH)D levels had higher TC, triglycerides, insulin and HOMA-IR levels (p < 0.05). MetS was detected in 57.8% (182/315) of women with hypovitaminosis D (insufficient and deficient) and in 39.8% (59/148) of those with sufficient VD​​ (p = 0.003).
In a multivariate logistic regression analysis, a low 25(OH)D level (<30 ng/mL) was significantly associated with

  • MetS (OR 1.90, 95%CI = 1.26-2.85),
  • high triglyceride levels (OR 1.55, 95%CI = 1.13-2.35), and
  • low HDL levels (OR 1.60, 95%CI = 1.19-2.40) (p < 0.05)

compared with women with sufficient 25(OH)D levels, after adjusting for age, time since menopause, body mass index, smoking and physical exercise. The mean concentration of 25(OH)D decreased with increasing numbers of MetS components (p = 0.016).

Conclusions
VD deficiency in postmenopausal women was associated with a higher prevalence of MetS. Women with VD deficiency had a higher risk of MetS, hypertriglyceridemia and low HDL than those with adequate levels.

 Download the PDF from VitaminDWiki
Image
Note: It appears from the PDF that the four MS components are
insulin, fasting glucose, hypertriglyceridemia, arterial hypertension
There are various MS lists on the internet - example:
hypertension, dyslipidemia, insulin resistance, hyperinsulinemia, glucose intolerance, and obesity

Created by admin. Last Modification: Saturday May 25, 2019 11:41:15 GMT-0000 by admin. (Version 17)

Attached files

ID Name Comment Uploaded Size Downloads
9561 MS Components.jpg admin 20 Mar, 2018 20:45 20.69 Kb 141
9560 Vitamin D deficiency is associated with metabolic syndrome in postmenopausal women.pdf PDF 2017 admin 20 Mar, 2018 20:44 272.87 Kb 74
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