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Metabolic Syndrome indicators inversely proportional to vitamin D below 46 ng – Nov 2018

Inverse Relationship between Metabolic Syndrome and 25-Hydroxyvitamin D Concentration in Elderly People without Vitamin D deficiency

Scientific Reports volume 8, Article number: 17052 (2018) https://doi.org/10.1038/s41598-018-35229-2
Chun-Min Wang, Chin-Sung Chang, Yin-Fan Chang, Shin-Jiuan Wu, Ching-Ju Chiu, Meng-Tzu Hou, Chuan-Yu Chen, Ping-Yen Liu & Chih-Hsing Wu

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Vitamin D vs number of Metabolic Syndrome Features

    Note: Could not find a list of the 5 MS features

Vitamin D status is inversely associated with the prevalence of metabolic syndrome (MetS). Whether this is true in the elderly without vitamin D deficiency is rarely investigated. Our data source is a cross-sectional survey of 1,966 community-dwelling elderly Taiwanese in 2012. An overnight fasting blood were obtained for biochemistry variables. Vitamin D deficiency was defined as serum 25-hydroxyvitamin D3 [25(OH)D] concentration <20 ng/mL. MetS is defined using modified ATP-III criteria. Of 523 participants without vitamin D deficiency (Men/Women = 269/254, age = 76.0 ± 6.2 years old [65–102 years old]), mean 25(OH)D was 44.0 ± 11.1 ng/mL, and the MetS prevalence of MS was 46.5%. Serum 25(OH)D was negatively associated with osteocalcin, the homeostatic model assessment insulin resistance (HOMA-IR) index, body mass index (BMI), and glycated hemoglobin A1c. Participants with more MetS features have lower serum 25(OH)D and osteocalcin. Binary logistic regression models showed that 25(OH)D, physical activity, and osteocalcin were negatively independent MetS factors, but that the HOMA-IR index, BMI, and being female were positively independent factors. The risk of MetS was progressively lower along with the increased 25(OH)D concentration, even above 60 ng/mL. In conclusion, a low 25(OH)D concentration is an independent risk factor for MetS in elderly people without vitamin D deficiency.

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Attached files

ID Name Comment Uploaded Size Downloads
10873 Number of MS features.jpg admin 19 Nov, 2018 22.24 Kb 686
10871 Metabolic syndrome associated with vitamin D.pdf admin 19 Nov, 2018 1.26 Mb 657