Loading...
 
Translate Register Log In Login with facebookLogin and Register

Metabolic Syndrome 3.5 X more likely if both Vitamin D and Estrogen are low (senior women)– June 2019

The synergistic effects of vitamin D and estradiol deficiency on metabolic syndrome in Chinese postmenopausal women.

Menopause. 2019 Jun 10. doi: 10.1097/GME.0000000000001370.
Huang H1,2, Guo J3,2, Chen Q4, Chen X4, Yang Y1, Zhang W5, Liu Y6, Chen X1, Yang D1.
1 Reproductive Medical Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
2 HH and JG equally contributed to this work and should be regarded as co-first authors.
3 Reproductive Medical Center, Beijing Chao Yang Hospital, Capital Medical University, Beijing, China.
4 Health Examination Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
5 Department of Environmental Health Sciences, University at Albany, State University of New York, NY.
6 Pediatric Department, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

VitaminDWiki



Image Image


Items in both categories Metabolic Syndrome and Intervention are listed here:

Items in both categories Metabolic Syndrome and Women are listed here:

Charts and description at Grassroots Health

Image

Image

OBJECTIVE:
Recent studies show that vitamin D (VitD) deficiency is associated with metabolic syndrome (MetS). Current evidence suggests that estrogen and VitD have similar physiological functions and potentially interact with bone health. We investigated the association between estradiol (E2) and 25-hydroxyvitamin-D 25(OH)D with MetS and its components in Chinese postmenopausal women.

METHODS:
In this cross-sectional study, we examined 616 postmenopausal women (aged 49-86 y) from southern China who were not taking estrogen and VitD/calcium supplements. At the end of data collection, serum E2 and 25(OH)D were measured for each participant. MetS was defined according to the 2006 International Diabetes Federation standard.

RESULTS:
There was a positive correlation between 25(OH)D and E2. Higher 25(OH)D was associated with a favorable lipid profile, blood pressure, and glucose level. E2 was negatively associated with cholesterol, triglycerides, and blood pressure. The odds ratio for MetS was 2.19 (95% CI, 1.19-4.01, P value for trend=0.009) for deficient compared with sufficient women after multivariable adjustment. This association remained unchanged after further adjusting for E2 levels. After stratified analysis by VitD status, low E2 increased MetS risk in women with VitD deficiency (odds ratio = 3.49, 95% CI, 1.45-8.05 for the lowest vs the highest tertile).

CONCLUSIONS:
These results suggest a synergistic role of VitD and E2 deficiency in MetS in Chinese postmenopausal women.

Created by admin. Last Modification: Tuesday June 25, 2019 13:45:05 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
12199 Metaboic Sy Vit D.jpg admin 25 Jun, 2019 10:35 55.09 Kb 45
12198 MS Estrogen Vit D.jpg admin 25 Jun, 2019 10:35 64.60 Kb 76
See any problem with this page? Report it (FINALLY WORKS)