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How Vitamin D prevents Hyperglycemia – Sept 2020

The Molecular Mechanisms by Which Vitamin D Prevents Insulin Resistance and Associated Disorders.

International Journal of Molecular Sciences, 10 Sep 2020, 21(18) DOI: 10.3390/ijms21186644
Szymczak-Pajor I1, Drzewoski J2, Śliwińska A1


Overview Diabetes and vitamin D contains the following

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 485 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

  • Appears that >2,000 IU will Prevent
  • Appears that >4,000 IU will Treat , but not cure
  • Appears that Calcium and Magnesium are needed for both Prevention and Treatment
    • which are just some of the vitamin D cofactors

Number of articles in both categories of Diabetes and:

  • Dark Skin 23;   Intervention 53;   Meta-analysis 34;   Obesity 29;  Pregnancy 40;   T1 (child) 38;  Omega-3 11;  Vitamin D Receptor 21;  Genetics 11;  Magnesium 19    Click here to see details

Diabetic Epidemic

  • Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
    Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
    That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
    Chart from the web (2018?)

 Download the PDF from VitaminDWiki
Many charts

Numerous studies have shown that vitamin D deficiency is very common in modern societies and is perceived as an important risk factor in the development of insulin resistance and related diseases such as obesity and type 2 diabetes (T2DM). While it is generally accepted that vitamin D is a regulator of bone homeostasis, its ability to counteract insulin resistance is subject to debate. The goal of this communication is to review the molecular mechanism by which vitamin D reduces insulin resistance and related complications. The university library, PUBMED, and Google Scholar were searched to find relevant studies to be summarized in this review article. Insulin resistance is accompanied by chronic hyperglycaemia and inflammation. Recent studies have shown that vitamin D exhibits indirect antioxidative properties and participates in the maintenance of normal resting ROS level.
Appealingly, vitamin D reduces inflammation and regulates Ca2+ level in many cell types. Therefore, the beneficial actions of vitamin D include diminished insulin resistance which is observed as an improvement of glucose and lipid metabolism in insulin-sensitive tissues

Created by admin. Last Modification: Wednesday December 2, 2020 18:55:21 GMT-0000 by admin. (Version 3)

Attached files

ID Name Comment Uploaded Size Downloads
14652 The Molecular Mechanisms.pdf PDF 2020 admin 02 Dec, 2020 18:53 784.43 Kb 167
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