Calcium/vitamin D supplementation, serum 25-hydroxyvitamin D concentrations, and cholesterol profiles in the Women's Health Initiative calcium/vitamin D randomized trial
Menopause March 2014
Schnatz, Peter F. DO, FACP, FACOG, NCMP; Jiang, Xuezhi MD, FACOG, NCMP; Vila-Wright, Sharon MD; Aragaki, Aaron K. MS; Nudy, Matthew BS; O’Sullivan, David M. PhD; Jackson, Rebecca MD; LeBlanc, Erin MD, MPH; Robinson, Jennifer G. MD, MPH; Shikany, James M. DrPH; Womack, Catherine R. MD; Martin, Lisa W. MD; Neuhouser, Marian L. PhD; Vitolins, Mara Z. DrPH, MPH, RD; Song, Yiqing MD, ScD; Kritchevsky, Stephen PhD; Manson, JoAnn E. MD, DrPH, NCMP
Objective: The objective of this study was to evaluate whether increased serum 25-hydroxyvitamin D3 (25OHD3) concentrations, in response to calcium/vitamin D (CaD) supplementation, are associated with improved lipids in postmenopausal women.
Methods: The parent trial was a double-blind, randomized, placebo-controlled, parallel-group trial designed to test the effects of CaD supplementation (1,000 mg of elemental calcium + 400 IU of vitamin D3 daily) versus placebo in postmenopausal women. Women from the general community, including multiple sites in the United States, were enrolled between 1993 and 1998. This cohort included 300 white, 200 African-American, and 100 Hispanic participants who were randomly selected from the Women's Health Initiative CaD trial. Serum 25OHD3 and lipid (fasting plasma triglycerides TG, high-density lipoprotein cholesterol HDL-C, and calculated low-density lipoprotein cholesterol LDL-C) levels were assessed before and after CaD randomization.
Results: There was a 38% increase in mean serum 25OHD3 concentrations after 2 years (95% CI, 1.29-1.47, P < 0.001) for women randomized to CaD (24.3 ng/mL postrandomization mean) compared with placebo (18.2 ng/mL).
Women randomized to CaD had a 4.46-mg/dL mean decrease in LDL-C (P = 0.03). Higher concentrations of 25OHD3 were associated with higher HDL-C levels (P = 0.003), along with lower LDL-C and TG levels (P = 0.02 and P < 0.001, respectively).
Conclusions: Supplemental CaD significantly increases 25OHD3 concentrations and decreases LDL-C. Women with higher 25OHD3 concentrations have more favorable lipid profiles, including increased HDL-C, lower LDL-C, and lower TG. These results support the hypothesis that higher concentrations of 25OHD3, in response to CaD supplementation, are associated with improved LDL-C.
Wonder how much reduced Cholesterol there would have been if a lot of vitamin D had been used.
Cholesterol category in VitaminDWiki starts with the following
- Less cholesterol in diet resulted in less vitamin D in blood (in mice) – Feb 2016
- Vitamin D levels are (again) associated with HDL cholesterol levels – Feb 2018
- More cholesterol is associated with more vitamin D – June 2013
- Cholesterol, Vitamins D3 and K2, heart disease, sulfates, LDL, – Masterjohn Interview Jan 2013
- Most Profitable Pill in Medical History Is Based on Flawed Science (Statins) May 2019
- Kids have recently reduced both cholesterol and vitamin D – Aug 2012
- Cholesterol is needed to produce both Vitamin D and Cortisol 2011?
- Cholesterol reduced by Vitamin D plus Calcium – RCT March 2014
- Eating less cholesterol is harmless other than it causes vitamin D deficiency – June 2011
- Vitamin D bioavailability is associated with cholesterol – Jan 2011
- Vitamin D increases HDL
- Overview Cholesterol and vitamin D
- Cholesterol and vitamin D book - 2009
- Proof that Vitamin D Works which includes this study as proof #41
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