Toggle Health Problems and D

60,000 IU of vitamin D monthly is healthy and safe – RCT Aug 2022

Efficacy and safety of various oral regimens (three oral doses) and schedules (daily vs. monthly) of cholecalciferol in north Indian adults with low vitamin D status: Evidence from a randomized controlled trial

Br J Nutr. 2022 Aug 19;1-22. doi: 10.1017/S0007114522002641
Mohd Ashraf Ganie 1 2 , Shivani Sidana 1 , Mohammad Salem Baba 1 , Tajali Sahar 2 , Aafia Rashid 2 , Mir Mahmood Asrar 2 , R K Marwaha 3 , Ishfaq Ahmad Wani 2 , Riyaz A Misgar 1 , Imtiyaz Ahmad Wani 2

Vitamin D (VD) deficiency [serum 25(OH)D concentration of <20 ng/ml], in endemic proportions, demands a supplementation strategy with optimal dosing regimens. A randomised parallel-group, active-controlled trial was conducted among apparently healthy, VD deficient subjects, age 18-60 years who received 600 IU/day (Group A), 1000 IU/day (Group B ), 2000 IU/day (Group C) and 60,000 IU/month (Group D) of oral cholecalciferol. The intervention was carried in two phases (I&II) of 12 weeks each, with same dose, separated by a washout phase of 12 weeks. Serum 25(OH)D, iPTH, calcium (Ca), phosphorous (PO4), alkaline phosphatase (ALP), spot urine calcium/creatinine (Ca/Cr) was measured at baseline, 12, 24 and 36 weeks following the intervention and adverse events were recorded at each occurrence and at 12, 24 and 36 weeks. A statistically significant time-group interaction was found in serum 25(OH)D concentration (P<0.05). Serum 25(OH)D concentration increased significantly from baseline to 12 weeks (P<0.05) in all the groups with no change at 24 weeks but further increase at 36 weeks (P<0.05). At the end of study, group C had maximum increment in serum 25(OH)D concentration while as groups C and D (95%, and 90%) had higher proportion of subjects VD sufficient than groups A and B (65% and 78%) (Table 3) (P<0.05). No significant time-dose interactions were observed in serum iPTH, Ca, PO4 and ALP or Urine Ca/Cr ratio. Three subjects (two in group C and one in group D) developed transient hypercalciuria. Supplementation with daily 2000IU or monthly 60,000IU oral cholecalciferol among adults seems optimal and safe.
 Download the PDF from VitaminDWiki

VitaminnDWiki - Is 50 ng of vitamin D too high, just right, or not enough

VitaminnDWiki - 50K twice a month fights all of the following

Diabetes + Heart Failure + Chronic Pain + Depression + Autism + Breast Cancer + Colon Cancer + Prostate Cancer + BPH (prostate) + Preeclampsia + Premature Birth + Falls + Cognitive Decline + Respiratory Tract Infection + Influenza + Tuberculosis + Chronic Obstructive Pulmonary Disease + Lupus + Inflammatory Bowel Syndrome + Urinary Tract Infection + Poor Sleep + Growing Pain + Multiple Sclerosis + PMS + Schizophrenia + Endometriosis + Smoking    27 problems
   Note: Once a week also fights: COVID, Headaches, Colds, Fibromyalgia, Asthma, Hives, Colitis etc.

VitaminnDWiki - Optimum category contains

The RDA is barely enough for the bones to survive.
   Need an optimal level for the body to thrive

99 items in Optimum Vitamin D category

Example pages


VitaminnDWiki - Consensus Vitamin D category contains

68 Vitamin D consensus publications

Attached files

ID Name Comment Uploaded Size Downloads
18296 60,000 IU monthly is healthy and safe - RCT.pdf admin 19 Aug, 2022 383.26 Kb 189