PLoS ONE 8(6): e66627. doi:10.1371/journal.pone.0066627
Stephen T. Goldring, Chris J. Griffiths, Adrian R. Martineau, Stephen Robinson, Christina Yu,
Sheree Poulton, Jane C. Kirkby, Janet Stocks, Richard Hooper, Seif O. Shaheen, John O. Warner, Robert J. Boyle
Observational studies suggest high prenatal vitamin D intake may be associated with reduced childhood wheezing.
We examined the effect of prenatal vitamin D on childhood wheezing in an interventional study.
We randomised 180 pregnant women at 27 weeks gestation to either no vitamin D, 800 IU ergocalciferol daily until delivery or single oral bolus of 200,000 IU cholecalciferol, in an ethnically stratified, randomised controlled trial. Supplementation improved but did not optimise vitamin D status. Researchers blind to allocation assessed offspring at 3 years. Primary outcome was any history of wheeze assessed by validated questionnaire. Secondary outcomes included atopy, respiratory infection, impulse oscillometry and exhaled nitric oxide. Primary analyses used logistic and linear regression.
We evaluated 158 of 180 (88%) offspring at age 3 years for the primary outcome. Atopy was assessed by skin test for 95 children (53%), serum IgE for 86 (48%), exhaled nitric oxide for 62 (34%) and impulse oscillometry of acceptable quality for 51 (28%). We found no difference between supplemented and control groups in risk of wheeze [no vitamin D: 14/50 (28%); any vitamin D: 26/108 (24%) (risk ratio 0.86; 95% confidence interval 0.49, 1.50; P = 0.69)]. There was no significant difference in atopy, eczema risk, lung function or exhaled nitric oxide between supplemented groups and controls.
Prenatal vitamin D supplementation in late pregnancy that had a modest effect on cord blood vitamin D level, was not associated with decreased wheezing in offspring at age three years.
Trial Registration Controlled-Trials.com ISRCTN68645785
Reduction in Inflammation almost was statistically significant
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Many studies have shown that 200,000 IU of vitamin D is not enough.
- Near the end of pregnancy 50,000 IU vitamin D weekly was great – RCT April 2013
- Overview Loading of vitamin D which has the following
A very commonly prescribed loading dose in the US is 50,000 IU per week for 8 weeks, for a total of 400,000 IU
- All Megadose vitamin D items
195 itemsSingle dose of 200,000 IU of vitamin D during pregnancy did not reduce wheezing 3 years later – June 2013 9219 visitors, last modified 18 Feb, 2015,