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Single dose of 200,000 IU of vitamin D during pregnancy did not reduce wheezing 3 years later – June 2013

Prenatal Vitamin D Supplementation and Child Respiratory Health: A Randomised Controlled Trial

PLoS ONE 8(6): e66627. doi:10.1371/journal.pone.0066627
Stephen T. Goldring, Chris J. Griffiths, Adrian R. Martineau, Stephen Robinson, Christina Yu,
Sheree Poulton, Jane C. Kirkby, Janet Stocks, Richard Hooper, Seif O. Shaheen, John O. Warner, Robert J. Boyle


Observational studies suggest high prenatal vitamin D intake may be associated with reduced childhood wheezing.
We examined the effect of prenatal vitamin D on childhood wheezing in an interventional study.

We randomised 180 pregnant women at 27 weeks gestation to either no vitamin D, 800 IU ergocalciferol daily until delivery or single oral bolus of 200,000 IU cholecalciferol, in an ethnically stratified, randomised controlled trial. Supplementation improved but did not optimise vitamin D status. Researchers blind to allocation assessed offspring at 3 years. Primary outcome was any history of wheeze assessed by validated questionnaire. Secondary outcomes included atopy, respiratory infection, impulse oscillometry and exhaled nitric oxide. Primary analyses used logistic and linear regression.

We evaluated 158 of 180 (88%) offspring at age 3 years for the primary outcome. Atopy was assessed by skin test for 95 children (53%), serum IgE for 86 (48%), exhaled nitric oxide for 62 (34%) and impulse oscillometry of acceptable quality for 51 (28%). We found no difference between supplemented and control groups in risk of wheeze [no vitamin D: 14/50 (28%); any vitamin D: 26/108 (24%) (risk ratio 0.86; 95% confidence interval 0.49, 1.50; P = 0.69)]. There was no significant difference in atopy, eczema risk, lung function or exhaled nitric oxide between supplemented groups and controls.

Prenatal vitamin D supplementation in late pregnancy that had a modest effect on cord blood vitamin D level, was not associated with decreased wheezing in offspring at age three years.
Trial Registration Controlled-Trials.com ISRCTN68645785

Reduction in Inflammation almost was statistically significant

PDF is attached at the bottom of this page

Comment by VitaminDWiki

Many studies have shown that 200,000 IU of vitamin D is not enough.

See also VitaminDWiki

Attached files

ID Name Comment Uploaded Size Downloads
2672 Inflamation.jpg admin 30 Jun, 2013 13:09 22.65 Kb 3792
2671 200,000 IU wheezing.pdf PDF 2013 admin 30 Jun, 2013 13:08 993.14 Kb 933