Wheezing and asthmatic children have weaker Vitamin D responses - May 2022


Vitamin D replacement in children with acute wheeze: a dose-escalation study

ERJ Open Research 2022 8: 00609-2021; DOI: 10.1183/23120541.00609-2021
Christos Stefanidis, Andrew Bush, Christopher Newby, Chinedu Nwokoro, Susan Liebeschuetz, Imogen P. Skene, Christopher J. Griffiths, Adrian R. Martineau

Vitamin D supplementation at the current UK recommended level (400 IU·day−1) or enhanced supplementation (1000 IU·day−1) failed to achieve adequate levels of vitamin D (>75 nmol·L−1) in vitamin-D-insufficient children with acute wheeze https://bit.ly/3J43Ouo

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To the Editor:

Meta-analyses report protective effects of vitamin D supplementation against asthma exacerbations and acute respiratory infections in adults [1–3], but data relating to effects of vitamin D on risk of preschool wheeze and asthma attacks in childhood are more limited [4]. In preparation for a randomised controlled trial (RCT) of vitamin D in children with recurrent preschool wheeze or school-age asthma, we carried out a dose-escalation study to find the daily vitamin D3 supplementation regimen that is most effective in elevating circulating 25-hydroxyvitamin D (25(OH)D) concentrations in these children. We hypothesised that daily oral vitamin D3 supplementation of 1000 IU would be more effective than 400 IU (UK recommendation [5]) in elevating the circulating 25(OH)D concentration to ≥75 nmol·L−1 at 3 months in vitamin-D-insufficient children with recurrent preschool wheeze or school-age asthma.

Children were recruited from primary and secondary care if they were aged 1–4 years with ≥2 self-reported episodes of acute wheeze requiring unscheduled healthcare attendances in the preceding year (preschool children), or aged 5–12 years with doctor-diagnosed asthma and ≥1 self-reported asthma attack requiring an unscheduled healthcare attendance in the preceding year (school children). Exclusion criteria were baseline 25(OH)D level ≥75 nmol·L−1, concurrent vitamin D supplementation, or a history of other chronic or acute respiratory or systemic conditions.
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15+ VitaminDWiki pages have WHEEZING in the title

This list is automatically updated

Items found: 15
Title Modified
Vitamin D levels are low during Recurrent Wheezing - Feb 2024 24 Feb, 2024
Asthma by age 7 if wheezing before preschools and poor vitamin D Receptor - May 2023 21 Dec, 2023
Recurrent Wheezing in children is associated with low Vitamin D – several studies 04 Sep, 2022
Wheezing and asthmatic children have weaker Vitamin D responses - May 2022 19 May, 2022
Vitamin D reduces RTI, Omega-3 reduces wheezing or asthma – March 2022 11 Apr, 2022
Viral infection wheezing 24X more likely if less than 15 ng of Vitamin D – Dec 2019 04 Apr, 2020
Gene which predicts wheezing is associated with low vitamin D – Oct 2019 18 Oct, 2019
Black infant recurrent wheezing rate dropped from 42 percent to 31 percent with just 400 IU of vitamin D – RCT Dec 2018 06 Dec, 2018
Recurrent wheeze 2X more likely if endotoxin (on some bacteria) and low vitamin D – May 2016 15 Dec, 2017
Wheezing reduced 35 percent if vitamin D added during pregnancy – April 2015 10 May, 2016
2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015 09 Sep, 2015
Infant wheezing 40 percent less likely if mother supplemented with vitamin D, vitamin E, or Zinc – meta-analysis Aug 2015 25 Aug, 2015
Children who wheezed were 2.7X more likely to have little vitamin D – April 2014 18 Apr, 2015
Vitamin D and wheeze – especially in seniors – Aug 2011 26 Apr, 2014
Single dose of 200,000 IU of vitamin D during pregnancy did not reduce wheezing 3 years later – June 2013 30 Jun, 2013

Study should have increased the dose size with increased weight or age

1000 IU per 25 lbs.jpg
Example: 1000 IU at 25 lbs, 3,000 IU at age 9


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