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Vitamin D sachets in India – fewer than a third had the stated amount – Nov 2013

Disparity in cholecalciferol content of commercial preparations available in India.

Indian J Endocrinol Metab. 2013 Nov;17(6):1100-3. doi: 10.4103/2230-8210.122638.
Khadgawat R1, Ramot R1, Chacko KM2, Marwaha RK2.

BACKGROUND: High prevalence of vitamin D deficiency (VDD) has been reported throughout the India for all age groups. Increased awareness about VDD among treating physicians has led to increased prescriptions of vitamin D preparations. Based on our experience of varied clinical and radiological response with different vitamin D formulations, we decided to assess cholecalciferol content of commonly available vitamin D formulations.

MATERIALS AND METHODS: We measured cholecalciferol content of 14 commercial preparations (two in the form of tablets and 12 as sachet) available in Indian market. Lab analysis was carried out in Shriram Institute for Industrial Research by high-performance liquid chromatography.

RESULTS: Of the total 14 samples analyzed only 4 (28.57%) were found to be within the acceptable ranges from -90 to +125% as defined by Indian Pharmacopia while 5 (35.7%) had higher and 5 (35.7%) had lower than the acceptable range. The percentage variation in cholecalciferol content as observed from the printed ranged widely from -91% to +65%.

CONCLUSIONS: Our study shows a high degree of variability in cholecalciferol content of commercial preparations available in the Indian pharmaceutical market. This variation has many clinical implications as it may lead both, under treatment as well as vitamin D toxicity.


PMID: 24381892

A few examples of 60,000 IU sachets in India

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$6 for 8 packages of 60,000 IU in India (via ebay - no shipping cost)

PDF is attached at the bottom of this page

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Attached files

ID Name Comment Uploaded Size Downloads
4142 D-sol sachet.jpg admin 13 Jul, 2014 15:38 14.57 Kb 25486
4141 India sachet 5.jpg admin 12 Jul, 2014 22:21 30.57 Kb 21462
4140 India sachet 4.jpg admin 12 Jul, 2014 22:20 67.36 Kb 22090
4139 India sachet 3.jpg admin 12 Jul, 2014 22:20 56.35 Kb 25849
4137 India sachet 1.jpg admin 12 Jul, 2014 22:20 73.11 Kb 34101
3491 India Dose.jpg admin 07 Jan, 2014 12:30 93.48 Kb 22560
3490 India dose.pdf PDF - 2013 admin 07 Jan, 2014 12:30 86.62 Kb 1508
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