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Vitamin D improves Sinovac vaccine (fast innate response) - July 2022

The Role of Vitamin D for Modulating the T Helper 1 Immune Response After the Coronavac Vaccination - July 2022

Journal of Interferon & Cytokine ResearchVol. 42, No. 7 Research Reports,
https://doi.org/10.1089/jir.2021.0218   PDF is behind a $51 paywall

The purpose of this study was to observe the role of vitamin D levels with T helper 1 (Th1)-type cytokines, such as interferon γ (IFN-γ) and interleukin-12 (IL-12) efficacy, in those who had already received 2 injections of inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) vaccines (CoronaVac). We also observed if these cytokines played any significance in the CoronaVac effectiveness for preventing coronavirus disease 2019 (Covid-19) infection.
One hundred ninety-four volunteers were monitored for 8 months upon receiving 2 inactivated SARS-CoV2 vaccination injections (CoronaVac, Sinovac Life Sciences). The rate of confirmed Covid-19 infections was the primary outcome.
Six to 7 weeks after the second vaccine injection, and blood samples were obtained to measure the serum vitamin D, IFN-γ, and IL-12 levels.
Low vitamin D level was defined if vitamin D level <30 ng/mL.
Subjects with low vitamin D had lower IFN-γ and IL-12 levels (P = 0.04 and P = 0.04, respectively). The receiver operating characteristics curve analysis revealed that the area under curve for IFN-γ was 0.59, whereas IL-12 was 0.59 for predicting the low vitamin D levels.

During follow-up, a higher incidence of Covid-19 infections was observed in subjects with low IFN-γ levels (P = 0.03). Kaplan–Meier survival analysis revealed that the cumulative hazard of confirmed Covid-19 cases was increased in subjects with low IFN-γ levels (log-rank test, P = 0.03). We concluded that lower vitamin D level was correlated with a lower Th1 immune response, whereas the adequate IFN-γ level was required to obtain better CoronaVac effectiveness.

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Enhanced protective immune response to PCV2 subunit vaccine by co-administration of recombinant porcine IFN-γ in mice
Wang, YP; Liu, D; Guo, LJ; Tang, QH; Wei, YW; Wu, HL; Liu, JB; Li, SB; Huang, LP; Liu, CM

  • COVID-19 vaccine research and development: ethical issues, Wibawa, T
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  • Mucosal IgA and IFN-γ+ CD8 T cell immunity are important in the efficacy of live Salmonella enteria serovar Choleraesuis vaccines

Zhu, L; Zhao, X; Yin, Q; Liu, X; Chen, X; Huang, C; Suo, X

Thymus helper = innate immune system = immediately kill invader

vs adpative immuse system which does not recongize variants and reaction is delayed by several days

Sinovac is as effective as m-RNA by 3 shot 9 nothing about Vitamin nore mutations) - April 2022


Note: Vitamin D is known to improve effectiveness of most inactivated vaccines

Sinovac: CoronaVac is used in 56 countries


VitaminDWiki pages containing INNATE in title (12 as of Aug 2022)

Items found: 14

Created by admin. Last Modification: Wednesday August 24, 2022 20:37:30 GMT-0000 by admin. (Version 13)

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