Loading...
 
Toggle Health Problems and D

Vitamin D improves Sinovac vaccine (fast innate response) - July 2022


The Role of Vitamin D for Modulating the T Helper 1 Immune Response After the Coronavac Vaccination - July 2022

Journal of Interferon & Cytokine ResearchVol. 42, No. 7 Research Reports,
https://doi.org/10.1089/jir.2021.0218   PDF is behind a $51 paywall

The purpose of this study was to observe the role of vitamin D levels with T helper 1 (Th1)-type cytokines, such as interferon γ (IFN-γ) and interleukin-12 (IL-12) efficacy, in those who had already received 2 injections of inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) vaccines (CoronaVac). We also observed if these cytokines played any significance in the CoronaVac effectiveness for preventing coronavirus disease 2019 (Covid-19) infection.
One hundred ninety-four volunteers were monitored for 8 months upon receiving 2 inactivated SARS-CoV2 vaccination injections (CoronaVac, Sinovac Life Sciences). The rate of confirmed Covid-19 infections was the primary outcome.
Six to 7 weeks after the second vaccine injection, and blood samples were obtained to measure the serum vitamin D, IFN-γ, and IL-12 levels.
Low vitamin D level was defined if vitamin D level <30 ng/mL.
Subjects with low vitamin D had lower IFN-γ and IL-12 levels (P = 0.04 and P = 0.04, respectively). The receiver operating characteristics curve analysis revealed that the area under curve for IFN-γ was 0.59, whereas IL-12 was 0.59 for predicting the low vitamin D levels.

During follow-up, a higher incidence of Covid-19 infections was observed in subjects with low IFN-γ levels (P = 0.03). Kaplan–Meier survival analysis revealed that the cumulative hazard of confirmed Covid-19 cases was increased in subjects with low IFN-γ levels (log-rank test, P = 0.03). We concluded that lower vitamin D level was correlated with a lower Th1 immune response, whereas the adequate IFN-γ level was required to obtain better CoronaVac effectiveness.

References
  • COvid-19 and high-dose VITamin D supplementation TRIAL in high-risk older patients (COVIT-TRIAL): study protocol for a randomized controlled trial, Annweiler, C; Beaudenon, M; Gautier, J; Simon, R; Dubée, V; Gonsard, J; Parot-Schinkel E;, COVIT-TRIAL study group
  • Effect of 25-hydroxyvitamin D status on serological response to influenza vaccine in prostate cancer patients, Chadha, MK; Fakih, M; Muindi, J; Tian, L; Mashtare, T; Johnson, CS; Trump, D
  • The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome. Chong, WP; Ip, WK; Tso, GH; Ng, MW; Wong, WH; Law, HK; Yung, RW; Chow, EY; Au, KL; Chan, EY; Lim, W; Peiris, JS; Lau, YL
  • Modulation of inflammatory and immune responses by vitamin D, Colotta, F; Jansson, B; Bonelli, F
  • Vitamin D supplementation ameliorates arthritis but does not alleviates renal injury in pristane-induced lupus model, Correa Freitas, E; Evelyn Karnopp, T; de Souza Silva, JM; Cavalheiro do Espírito Santo, R; da Rosa, TH; de Oliveira, MS; da Costa Gonçalves, F; de Oliveira Francine, H; Schaefer Pedro, G; Monticielo Odirlei, A
  • T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial
  • Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages. Fabri, M; Stenger, S; Shin, DM; Yuk, JM; Liu, PT; Realegeno, S; Lee, HM; Krutzik, SR; Schenk, M; Sieling, PA; Teles, R; Montoya, D; Iyer, SS; Bruns, H; Lewinsohn, DM; Hollis, BW; Hewison, M; Adams, JS; Steinmeyer, A; Zügel, U; Cheng, G; Jo, EK; Bloom, BR; Modlin, RL
  • Development of an inactivated vaccine candidate for SARS-CoV-2, Gao, Q; Bao, L; Mao, H; Wang, L; Xu, K; Yang, M; Li, Y; Zhu, L; Wang, N; Lv, Z; Gao, H; Ge, X; Kan, B; Hu, Y; Liu, J; Cai, F; Jiang, D; Yin, Y; Qin, C; Li, J; Gong, X; Lou, X; Shi, W; Wu, D; Zhang, H; Zhu, L; Deng, W; Li, Y; Lu, J; Li, C; Wang, X; Yin, W; Zhang, Y; Qin, C
  • Effectiveness of an inactivated SARS-CoV-2 vaccine in Chile, Jara, A; Undurraga, EA; González, C; Paredes, F; Fontecilla, T; Jara, G; Pizarro, A; Acevedo, J; Leo, K; Leon, F; Sans, C; Leighton, P; Suárez, P; García-Escorza, H; Araos, R
  • Calcitriol-mediated reduction in IFN-γ output in T cell large granular lymphocytic leukemia requires vitamin D receptor upregulation Kulling, PM; Olson, KC; Olson, TL; Hamele, CE; Carter, KN; Feith, DJ; Loughran, TP
  • Interleukin-12: an update on its immunological activities, signaling and regulation of gene expression, Liu, J; Cao, S; Kim, S; Chung, EY; Homma, Y; Guan, X; Jimenez, V; Ma, X
  • CD4+ T cells: differentiation and functions, Luckheeram, RV; Zhou, R; Verma, AD; Xia, B
  • Current state of vaccine development and targeted therapies for COVID-19: impact of basic science discoveries, Marian, AJ
  • COVID-19: virology, biology and novel laboratory diagnosis, Mohamadian, M; Chiti, H; Shoghli, A; Biglari, S; Parsamanesh, N; Esmaeilzadeh, A
  • The relationship between Th1/Th2 balance and 1α,25-dihydroxyvitamin D3 in patients with nasal polyposis; Ozkara, S; Keles, E; Ilhan, N; Gungor, H; Kaygusuz, I; Alpay, HC
  • Baseline serum vitamin A and D levels determine benefit of oral vitamin a&D supplements to humoral immune responses following pediatric influenza vaccination; Patel, N; Penkert, RR; Jones, BG; Sealy, RE; Surman, SL; Sun, Y; Tang, L; DeBeauchamp, J; Webb, A; Richardson, J; Heine, R; Dallas, RH; Ross, AC; Webby, R; Hurwitz, JL
  • COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses
  • The Ifng gene is essential for Vdr gene expression and vitamin D3-mediated reduction of the pathogenic T cell burden in the central nervous system in experimental autoimmune encephalomyelitis, a multiple sclerosis model; Spanier, JA; Nashold, FE; Olson, JK; Hayes, CE
  • Low levels of vitamin D were associated with coagulopathy among hospitalized coronavirus disease-19 (COVID-19) patient: a single centered study in Indonesia; Susianti, H; Wahono, CS; Rahman, PA; Pratama, MZ; Wulanda, IA; Hartanti, KD; Dewi, ES; Handono, K

Enhanced protective immune response to PCV2 subunit vaccine by co-administration of recombinant porcine IFN-γ in mice
Wang, YP; Liu, D; Guo, LJ; Tang, QH; Wei, YW; Wu, HL; Liu, JB; Li, SB; Huang, LP; Liu, CM

  • COVID-19 vaccine research and development: ethical issues, Wibawa, T
  • Immune effect of a Newcastle disease virus DNA vaccine with IL-12 as a molecular adjuvant delivered by electroporation, Xie, P; Li, Y; Li, Y; Liang, J; Xiang, B; Lin, Q; Jin, J; Ding, C; Xu, C; Ren, T
  • Enhanced protective immunity to CSFV E2 subunit vaccine by using IFN-γ as immunoadjuvant in weaning piglets, Zhang, H; Wen, W; Zhao, Z; Wang, J; Chen, H; Qian, P; Li, X
  • Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18–59 years: a randomized, double-blind, placebo-controlled, phase 1/2 clinical trial. Zhang, Y; Zeng, G; Pan, H; Li, C; Hu, Y; Chu, K; Han, W; Chen, Z; Tang, R; Yin, W; Chen, X; Hu, Y; Liu, X; Jiang, C; Li, J; Yang, M; Song, Y; Wang, X; Gao, Q; Zhu, F
  • Mucosal IgA and IFN-γ+ CD8 T cell immunity are important in the efficacy of live Salmonella enteria serovar Choleraesuis vaccines

Zhu, L; Zhao, X; Yin, Q; Liu, X; Chen, X; Huang, C; Suo, X


Thymus helper = innate immune system = immediately kill invader

vs adpative immuse system which does not recongize variants and reaction is delayed by several days


Sinovac is as effective as m-RNA by 3 shot 9 nothing about Vitamin nore mutations) - April 2022

Economist


Note: Vitamin D is known to improve effectiveness of most inactivated vaccines


Sinovac: CoronaVac is used in 56 countries

https://covid19.trackvaccines.org/vaccines/7/


VitaminDWiki pages containing INNATE in title (12 as of Aug 2022)

Items found: 14






Created by admin. Last Modification: Wednesday August 24, 2022 20:37:30 GMT-0000 by admin. (Version 13)

Attached files

ID Name Comment Uploaded Size Downloads
18319 Sinovac 1 2 3.jpg admin 24 Aug, 2022 74.93 Kb 78