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5000 IU of vitamin D in daily bread resulted in 50 ng and improved quality of life– May 2014

Vitamin d fortified bread improves pain and physical function domains of quality of life in nursing home residents.

J Med Food. 2014 May;17(5):625-31. doi: 10.1089/jmf.2012.0210.
Costan AR1, Vulpoi C c.vulpoi at yahoo.fr, Mocanu V.
1 Department of Endocrinology, Grigore T. Popa University of Medicine and Pharmacy , Iasi, Romania .

Abstract Nursing home residents have severe vitamin D deficiency and increased risk of falls and fractures. These individuals may need 125 μg of vitamin D3 to achieve desirable 25-hydroxyvitamin D [25(OH)D] concentrations to improve overall health. We evaluated health-related quality of life (HRQoL) in 45 nursing home residents (28 women and 17 men, aged 58-89 years) with 25(OH)D concentrations <50 nM who consumed daily one bun that had been fortified with 125 μg vitamin D3. The Romanian version of Questionnaire of the European Foundation for Osteoporosis (QUALEFFO-41) was applied at baseline and after 12 months. Data were analyzed using repeated measures analyses of variance (ANOVA).

After one year supplementation, serum 25(OH)D reached optimal status (>75 nM) and bone health has improved significantly. Nursing home residents who consumed daily bread fortified with 125 μg vitamin D3 reported significant (P=.02 for the effect of time) improvement in HRQoL (total score of QUALEFFO-41). The interaction time x treatment was also statistically significant on pain (P=.04), daily activities (P=.02), and locomotion (P=.04). To ensure the serum concentrations of 25(OH)D recommended by medical groups for bone- and general-health in the older nursing residents, the practical experience shows that much higher amounts of vitamin D3 are required. Fortification of bread and cereals is a feasible way to improve vitamin D nutrition.
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Average level achieved = 125 nmol = 50 ng

Questionnaire of the European Foundation for Osteoporosis

English version is attached at the bottom of this page

See also VitaminDWiki

Bread Fortification

VitaminDWiki Fortification pages with BREAD in title

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Note: the 2014 and 2009 entries appear to be the same study

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Attached files

ID Name Comment Uploaded Size Downloads
15288 Food fortificantion 5,000 IU daily in bread.pdf admin 20 Mar, 2021 147.32 Kb 392
3927 Qualeffo41-questionnaire-England_0_0.pdf admin 20 May, 2014 138.04 Kb 1862