Obstructive sleep apnea and objective short sleep duration are independently associated with the risk of serum vitamin D deficiency
PLOS ONE, Published: July 7, 2017 https://doi.org/10.1371/journal.pone.0180901
Ronaldo D. Piovezan , Camila Hirotsu, Marcia C. Feres, Fatima D. Cintra, Monica L. Andersen, Sergio Tufik, Dalva Poyares
- Sleep Apnea patients – 98 percent had low vitamin D – Feb 2016
- Sleep disorders cured by 60-80 ng of vitamin D and some B vitamins – March 2013
- Sleeps disorders nicely treated by Vitamin D (50,000 IU bi-weekly) – RCT May 2017
- The Better Sleep Vitamin (Vitamin D) – nice 3 dollar book Feb 2015
- Poor sleep associated with 2X increase risk of Metabolic problems (both low Vitamin D) – May 2019
- 4.5X more likely to catch a cold if low sleep - hypothesis - due to low vitamin D
- Longer time to fall to sleep in winter unless eat salmon (vitamin D and Omega-3) – May 2014
- More screen time, less sleep (probably due to less vitamin D) – Feb 2015
- Sleep Apnea 171 items as of Sept 2017
Studies demonstrate an association between vitamin D (25(OH)D) deficiency and sleep disturbances, such as obstructive sleep apnea (OSA) and short sleep duration. However, to date, no studies have concurrently and objectively evaluated the effect of these factors on 25(OH)D.
To evaluate whether OSA and objective short sleep duration are independently associated with reduced 25(OH)D in an adult population sample.
A cross-sectional study included 657 individuals from the city of Sao Paulo, Brazil, as part of the ERA project. Participants fulfilled questionnaires and underwent clinical evaluation, polysomnography and blood sample collection for 25(OH)D quantification. OSA was classified into three categories (mild, moderate and severe). The risk of 25(OH)D deficiency was considered as levels<30 ng/mL. Short sleep duration was defined as total sleep time<6 hours.
The risk of 25(OH)D deficiency was observed in 59.5% of the sample, affecting more individuals of the female gender, obese, with African American ethnicity, and those that were smokers, sedentary and presented hypertension and diabetes. In the final logistic model adjusted for age, gender, ethnicity, obesity, smoking, hypertension, diabetes, sedentary lifestyle, seasonality and creatinine serum levels, both OSA and short sleep duration showed significant independent associations with the risk of 25(OH)D deficiency (moderate OSA: OR for 25(OH)D<30 = 2.21, 95% CI: 1.35–3.64, p<0.01; severe OSA: OR for 25(OH)D<30 = 1.78, 95% CI: 1.06–3.00, p = 0.03; short sleep duration: OR for 25(OH)D<30 = 1.61, 95% CI: 1.15–2.26, p = 0.01). After a subgroup analysis, similar results were observed only in participants ≥50 years.
OSA and short sleep duration are independently associated with the risk of 25(OH)D deficiency in an adult population. Age-related changes in vitamin D metabolism and the frequency of sleep disorders may be involved in these associations. Future studies exploring whether 25(OH)D levels may modulate OSA and sleep curtailment-related outcomes are needed.