Prevalence of vitamin D deficiency in rheumatoid arthritis and association with disease activity and cardiovascular risk factors: data from the COMEDRA study.
Clin Exp Rheumatol. 2016 Sep 30. [Epub ahead of print]
Cecchetti S1, Tatar Z1, Galan P2, Pereira B3, Lambert C3, Mouterde G4, Sutton A5, Soubrier M6, Dougados M7.
Vitamin D deficiency levels
|10-30 ng||< 10 ng|
Noted. There is probably an error: 59% + 56% is > 100%
See also VitaminDWiki
- Every patient with rheumatoid arthritis had low vitamin D, severity was proportional to degree of deficiency – June 2014
- Active Rheumatologic disease was 5X more likely with low vitamin D – June 2013
- Rheumatoid Arthritis strongly associated with low vitamin D – meta-analysis April 2016
- Rheumatoid arthritis is 40 percent more likely if vitamin D Receptor problem – 2 meta-analyses 2015
- Overview Rheumatoid Arthritis and vitamin D
1Department of Rheumatology, Clermont-Ferrand University Hospital, France.
2Paris 13 University, Sorbonne Paris Cité, Nutritional Epidemiology Research Unit, INSERM (U1153), Bobigny, France.
3Biostatistics Department, Clermont-Ferrand University Hospital, France.
4Department of Rheumatology, Lapeyronie Hospital, Montpellier 1 University, EA2415, Montpellier, France.
5Biochemistry Department, Jean Verdier Hospital, APHP, Bondy; Paris 13 University, Sorbonne Paris Cité, Laboratory for Vascular Translational Science, INSERM (U1148), Bobigny, France.
6Department of Rheumatology, Clermont-Ferrand University Hospital, France. msoubrier at chu-clermontferrand.fr.
7Paris Descartes University, Department of Rheumatology, Hôpital Cochin, Assistance Publique, Hôpitaux de Paris, INSERM (U1153), Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France.
The relationship between vitamin D and rheumatoid arthritis (RA) activity remains controversial. RA is a cardiovascular risk factor. A low level of vitamin D may increase blood pressure (BP) and decrease HDL-cholesterol.
We aimed to determine the prevalence of vitamin D deficiency in RA patients compared to controls, and also to investigate the relationship between vitamin D and RA activity, and between vitamin D and cardiovascular risk factors.
Patients in the COMEDRA study with established inactive RA (1987 ACR criteria) were matched with subjects from the NUTRINET-SANTE cohort (age, gender, latitude, sampling season). Vitamin D deficiency was defined as <10 ng/mL, and insufficiency as 10 to 29.9 ng/mL.
Eight hundred and ninety-four RA patients were analysed, of which 861 were matched with controls. The prevalence of vitamin D insufficiency and deficiency was lower in RA patients than in controls: 480 (55.8%) vs. 508 (59%) and 31 (3.6%) vs. 45 (5.23%), respectively; p=0.04. There was an inverse correlation between vitamin D levels and RA activity assessed by DAS28-CRP (p=0.01), SDAI (p<0.001) and CDAI (p=0.001), but not DAS28-ESR after adjustment for age, gender, inclusion season, body mass index (BMI), vitamin D supplementation, disease duration, RF or anti-CCP status and RA treatments. Vitamin D levels were inversely correlated with BMI (p<0.001), but not with BP, total cholesterol, LDL-cholesterol, HDL-cholesterol or blood glucose.
This study demonstrates that vitamin D is inversely correlated with RA activity and BMI, but not with other cardiovascular risk factors.