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Vitamin D is only of only 2 ways to easily prevent NAFLD (380,000 people) – Oct 2021


Associations of Nutritional, Lifestyle, and Metabolic Factors With Non-alcoholic Fatty Liver Disease: An Umbrella Review With More Than 380,000 Participants

Front Nutr. 2021 Sep 17;8:642509. doi: 10.3389/fnut.2021.642509. eCollection 2021.
Yang Xia 1 2, Qijun Wu 1 2, Huixu Dai 1 2, Jiale Lv 1 2, Yashu Liu 1 2, Hui Sun 1 2, Yuting Jiang 1 2, Qing Chang 1 2, Kaijun Niu 3, Yuhong Zhao 1 2

Subset of tables - looking only at prevention factors
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Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is the most common liver injury. We performed this umbrella review of meta-analyses to summarize the evidence on the associations of nutritional, lifestyle, and metabolic factors with NAFLD.

Methods: We searched the PubMed, Embase, and Web of Science databases from inception until July 2, 2020, to identify meta-analyses of observational studies which explored the associations of nutritional, lifestyle, and metabolic factors with NAFLD. Evidence levels were assessed using summary effect sizes, 95% prediction intervals, between-study heterogeneity, evidence of small-study effects, and evidence of excess significance bias for each meta-analysis. (No. of PROSPERO, CRD42020200124).

Results: Twenty two risk or protective factors from 10 published meta-analyses were included and studied. Three risk factors (sugar-sweetened beverage consumption, serum fetuin-A, and waist circumference) with highly suggestive levels of evidence and three risk factors (soft drink consumption, former smoking, and body mass index) with suggestive levels of evidence were identified.

Only two protective factors (physical activity and serum vitamin D level [among adults in Western countries]) with suggestive levels of evidence were identified. Furthermore, other six risk factors and two protective factors with weak levels of evidence were identified.

Conclusions: We found varying levels of evidence of associations of nutritional, lifestyle, and metabolic factors and NAFLD. The results suggest that nutritional and lifestyle management should be considered as a major primary preventive strategy for NAFLD. Moreover, considering the low quality of included meta-analyses and limited area of research topics, future high-quality original studies and meta-analyses should be performed to study these associations.


VitaminDWiki pages with NON-ALCOHOLIC or NAFLD in title (23 as of July 2022)

This list is automatcially updated

Items found: 23
Title Modified
Non-alcoholic fatty liver disease: 75 percent of overweight adults and type II diabetics – Aug 2022 16 Jul, 2022
NAFLD not reduced by 1680 IU of vitamin D plus Omega-3 (no surprise) – RCT Jan 2022 24 Jan, 2022
NAFLD was no longer associated with low vitamin D after “adjusting’ for obesity – May 2021 02 Nov, 2021
Liver Inflammation (NAFLD) is prevented by Vitamin D – review May 2015 05 Oct, 2021
Non-Alcoholic Fatty Liver Disease (NAFLD) treated by Vitamin D (20,000 IU weekly after loading dose) – RCT June 2016 05 Oct, 2021
Vitamin D is only of only 2 ways to easily prevent NAFLD (380,000 people) – Oct 2021 05 Oct, 2021
NAFLD somewhat treated in children with 2,000 IU Vitamin D daily – RCT Aug 2021 30 Aug, 2021
Strong association of non alcoholic fatty liver disease and low vitamin D 28 Oct, 2020
Non-alcoholic Fatty Liver Disease (NAFLD) treated by Vitamin D (in rats this time) – Dec 2019 04 Dec, 2019
Non-alcoholic fatty liver disease and the Vitamin D Receptor – editorial Sept 2019 29 Sep, 2019
NAFLD associated with low vitamin D (in children too) – meta-analysis Aug 2019 06 Aug, 2019
Severe Non-Alcoholic fatty liver disease treated by Omega-3 – RCT April 2018 02 Mar, 2019
Non-alcoholic Fatty Liver Disease (4 in 10 seniors) and Vitamin D 26 Aug, 2018
NAFLD is treated by Vitamin D, Omega-3, Curcumin, Silymarinm, etc. Aug 2018 26 Aug, 2018
Non-Alcoholic Fatty Liver Disease treated by Omega-3 – three meta-analysis 2016-2017 13 Aug, 2017
Non-Alcoholic Fatty Liver Disease treated by Omega-3 – meta-analysis Oct 2016 13 Aug, 2017
Non-alcoholic fatty liver disease associated with much lower vitamin D – Aug 2014 24 Jul, 2016
Non-alcoholic fatty liver disease (NAFLD) reduced somewhat by 50,000 IU vitamin D every 2 weeks – RCT Sept 2014 13 Jul, 2016
Sarcopenia and non-alcoholic fatty liver disease (vitamin D not mentioned) – Sept 2013 07 Mar, 2015
Hepatitis C, non-alcoholic fatty liver disease and vitamin D deficiency – Dec 2014 31 Dec, 2014
Non-alcoholic fatty liver disease associated with low vitamin D – independent of BMI – June 2014 31 Dec, 2014
Fatty liver disease (NAFLD), metabolic syndrome, and perhaps vitamin D – June 2013 24 Mar, 2014
Fatty liver disease (NAFLD) and the importance of vitamin D – Oct 2012 25 Jul, 2013

VitaminDWiki Meta-analyses with NON-ALCOHOLIC or NAFLD in title (4 as of April 2022)

This list is automatcially updated

Items found: 2

Created by admin. Last Modification: Saturday July 16, 2022 13:46:12 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
16370 Risk NAFLD.jpg admin 05 Oct, 2021 21:45 43.70 Kb 91
16369 NAFLD prevention.jpg admin 05 Oct, 2021 21:45 32.36 Kb 97
16368 NAFLD vitamin D protection.pdf PDF 2021 admin 05 Oct, 2021 21:44 1.05 Mb 83
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