- Effect of vitamin D3 administration on chemotherapy response in advanced stage nasopharyngeal carcinoma patients receiving cisplatin-based regimen
- Vitamin D increases the efficacy of cisplatin on bladder cancer cell lines - Nov 2022
- A vitamin D-based strategy overcomes chemoresistance in prostate cancer - July 2024
- Two doses of 100,000 IU vitamin D shortened Chemo skin recovery time for 2 weeks to 2 days - Dec 2022
- 29+ VitaminDWiki pages have CHEMOTHERAPY in the title
- 4+ VitaminDWiki pages have CISPLATIN in the title
- VitaminDWiki – Cancer - After diagnosis category contains:
Effect of vitamin D3 administration on chemotherapy response in advanced stage nasopharyngeal carcinoma patients receiving cisplatin-based regimen
International Journal of Otolaryngology Sciences 2024; 6(1): 06-11 https://doi.org/10.33545/26649225.2024.v6.i1a.10
Rini Kartika Dewi, Made Setiamika and Hadi Sudrajad
Introduction: Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from epithelial cells of the nasopharynx. Cisplatin is the first-line drug for chemotherapy in NPC patients. Chemoresistance is a major cause of oral cancer progression and mortality. Research has revealed the anticancer properties of vitamin D, suggesting that it can impede the development of cancer. This study is to determine the effect of vitamin D3 administration on chemotherapy response in advanced NPC patients who were receiving Cisplatin-based chemotherapy.
Methods: This research is an analytic observational study with a pretest-posttest sectional design. The research sample was NPC Stage III and IV patients in Sub-Oncology of Otorhinolaryngology-Head and Neck Surgery clinic undergoing neoadjuvant chemotherapy, whose chemotherapy response was assessed based on two groups, namely the neoadjuvant chemotherapy group and neoadjuvant chemotherapy with 1000 IU Vitamin D3 premedication.
Results: This study involved 32 patients with NPC stage III and IV, with 75% male and 25% female. The average age was 49 years. Most of the patients were in stage IV, which was 87.5%, while stage III was 12.5%. The neoadjuvant chemotherapy group had 56.3% with positive chemotherapy responses and 43.8% negative responses, while the neoadjuvant chemotherapy group with Vit D3 premedication had 93.8% with positive responses, and 6.3% negative responses. The statistical test results obtained p = 0.037, which means that there was a significant effect of vitamin D3 administration on chemotherapy response in advanced NPC patients who were receiving Cisplatin-based chemotherapy.
Conclusion: Administration of Cisplatin-based Neoadjuvant chemotherapy with 1000 IU vitamin D3 premedication has an effect 2.33 times more effective in increasing chemotherapy response compared to neoadjuvant therapy alone.
Download the PDF from VitaminDWiki
Vitamin D increases the efficacy of cisplatin on bladder cancer cell lines - Nov 2022
Mol Biol Rep 50, 697–706 (2023). https://doi.org/10.1007/s11033-022-08044-2 PDF behind paywall
A vitamin D-based strategy overcomes chemoresistance in prostate cancer - July 2024
https://doi.org/10.1111/bph.16492 FREE PDF
Two doses of 100,000 IU vitamin D shortened Chemo skin recovery time for 2 weeks to 2 days - Dec 2022
High-Dose Vitamin D for the Management of Toxic Erythema of Chemotherapy in Hospitalized Patients
FREE PDF
29+ VitaminDWiki pages have CHEMOTHERAPY in the title
The list is automatically updated
4+ VitaminDWiki pages have CISPLATIN in the title
The list is automatically updated
VitaminDWiki – Cancer - After diagnosis category contains:
- Most cancers reduce vitamin D levels
- Most cancer treatments (chemo, radiation) further lower Vitamin D
- Higher levels of vitamin D minimize many side-effects of cancer therapy
- High levels of vitamin D augment many chemotherapies
- High levels of vitamin D augment cancer immunotherapies
- High levels of vitamin D can kill some cancer cells 1,720 items 12/2023
- Some cancers deactivate the vitamin D receptor
Example VitaminDWiki Studies
- Cancer and Vitamin D - many studies
- Easiest way to treat cancer – take Vitamin D – Nov 2022
- Even after a Cancer diagnosis Vitamin D improves survival – meta-analysis Aug 2022
- Vitamin D is synergistic with many Cancer therapies (radiation in this case) – Aug 2021
- Vitamin D prevents and treats cancer in many ways – May 2021
- Cancer patients need more vitamin D, even those who are supplementing – observational study June 2021
- Metastatic Cancer probably reduced by vitamin D - many studies
- Colorectal Cancer treatment aided by omega-3 plus weekly Vitamin D – RCT Sept 2019
- Radiation therapy, used to treat some cancers, causes less damage if use Vitamin D (or Melatonin) – Aug 2022
- Vitamin D is synergistic with many Cancer therapies (radiation in this case) – Aug 2021
- Vitamin D prevents and treats cancer in many ways – May 2021
- Palliative care is helped by Vitamin D - many studies
- 4X less of one chemo needed after vitamin D receptor activation - June 2020
Breast Cancer
- Breast Cancer survivors with high vitamin D were 3.3 X less likely to have metastases – May 2023
- Breast Cancer survival: 44% with just 10,000 IU of vitamin D per week, 33% with placebo – RCT Dec 2023
- Breast cancer recurred twice as often if have less than 20 ng of vitamin D – Dec 2018
- Breast Cancer chemotherapy 2.7 X more likely to be successful if not vitamin D deficient – Dec 2017