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Cancer Chemotherapy and vitamin D – Review March 2013

Vitamin D: Pharmacokinetics and Safety When Used in Conjunction with the Pharmaceutical Drugs Used in Cancer Patients: A Systematic Review

Cancers 2013, 5(1), 255-280; doi:10.3390/cancers5010255
Deborah A. Kennedy 1 , Kieran Cooley 1 , Becky Skidmore 1 Heidi Fritz 1 , Tara Campbell 1 email and Dugald Seely 1,2, dseely at ccnm.edu
1 Canadian College of Naturopathic Medicine, 1255 Sheppard Avenue East, Toronto, Ontario, M2K 1E2, Canada 2 Ottawa Integrative Cancer Centre, 29 Bayswater Avenue, Ottawa, Ontario, K1Y 2E5, Canada

Vitamin D has reported anti-cancer and anti-inflammatory properties modulated through gene transcription and non-genomic signaling cascades. The purpose of this review was to summarize the available research on interactions and pharmacokinetics between vitamin D and the pharmaceutical drugs used in patients with cancer. Hypercalcemia was the most frequently reported side effect that occurred in high dose calcitriol.

The half-life of 25(OH)D3 and/or 1,25(OH)2D3 was found to be impacted by cimetidine; rosuvastatin; prednisone and possibly some chemotherapy drugs.

No unusual adverse effects in cancer patients; beyond what is expected from high dose 1,25(OH)2D3 supplementation, were revealed through this review.

While sufficient evidence is lacking, supplementation with 1,25(OH)2D3 during chemotherapy appears to have a low risk of interaction. Further interactions with vitamin D3 have not been studied.

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See also VitaminDWiki

see wikipage: http://www.vitamindwiki.com/tiki-index.php?page_id=396

Attached files

ID Name Comment Uploaded Size Downloads
2191 Chemo A3.jpg admin 12 Mar, 2013 66.84 Kb 2502
2190 Chemo and vitamin D.jpg admin 12 Mar, 2013 46.40 Kb 2236
2189 cancers-05-00255.pdf admin 12 Mar, 2013 617.25 Kb 848