Low cord-serum 25-hydroxyvitamin D levels are associated with poor lung function performance and increased respiratory infection in infancy
PLoS One. 2017; 12(3): e0173268. PMCID: PMC5340372
Shen-Hao Lai,1,2,3 Sui-Ling Liao,2,3,4 Ming-Han Tsai,2,3,4 Man-Chin Hua,2,3,4 Chih-Yung Chiu,2,3,4 Kuo-Wei Yeh,1,2,3 Tsung-Chieh Yao,#1,2,3,* and Jing-Long Huang#1,2,3,*
7X increased Respiratory problems within 6 months if cord level vitamin D level as low (Less than the mean of 13.8 ng/mL)
- Respiratory tract infections in childhood – vitamin D is needed, no consensus of how much – Oct 2015
- Respiratory distress after preterm birth is more likely if low vitamin D – review April 2015
- All preemies with Chronic Lung Disease had low vitamin D levels– July 2015
- Acute Lower Respiratory Infections in Children - associated with low vitamin D – meta-analysis Dec 2014
- Respiratory Tract visits 2.5 less likely with vitamin D: Pregnancy 2000 IU, Infant 800 IU – RCT Oct 2014
- Acute lower respiratory infection 5X more frequent with low vitamin D intake – June 2012
- Vitamin D response time is 3-6 months, not much benefit in first 4 months – RCT July 2017
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Perinatal vitamin D deficiency is associated with a higher risk of wheezing in childhood. However, the relationship between vitamin D levels and lung function in infancy has not been investigated. The aim of this study was to investigate the impact of perinatal vitamin D levels on respiratory function and disease outcome in infancy.
Materials and methods
Full-term infants without any chronic diseases or major anomalies were enrolled in the Prediction of Allergies in Taiwanese Children cohort study. Maternal and cord blood were collected for determining the 25(OH)D level. Questionnaires were recorded at birth and 6 months of age. Infant lung function, including tidal breathing analysis, respiratory mechanics, and forced tidal expiration, was tested at 6 months of age.
A total of 122 mother—infant pairs were enrolled in this study, and 71 infants underwent lung function testing at 6 months of age. 25(OH)D levels in maternal and cord serum were highly correlated (r2 = 0.457, p < 0.0001). Infants with lower cord serum 25(OH)D levels (< 13.7 ng/ml) had higher resistance of respiratory system (p < 0.01) and a higher risk of a respiratory tract infection before the age of 6 months (p < 0.01).
Although a high correlation was found between maternal and cord vitamin D levels, the effect on respiratory outcome was different. Our study is the first to show that low cord 25(OH)D levels significantly relationship with poorer lung function performance and higher likelihood of a respiratory tract infection before 6 months of age.