Vitamin D mitigates age-related cognitive decline through the modulation of pro-inflammatory state and decrease in amyloid burden
Teresita L Briones and Hala Darwish
Journal of Neuroinflammation 2012, 9:244 doi:10.1186/1742-2094-9-244
Published: 25 October 2012
Increasing evidence shows an association between the use of vitamin D and improvement in age-related cognitive decline. In this study, we investigated the possible mechanisms involved in the neuroprotective effects of vitamin D on age-related brain changes and cognitive function.
Male F344 rats aged 20 months (old) and 6 months (young) were used and randomly assigned to either vitamin D supplementation or no supplementation (control). A total of n = 39 rats were used in the study. Rats were individually housed and the supplementation group received a subcutaneous injection of vitamin D (1, alpha25-dihydroxyvitamin D3) 42 I.U./Kg for 21 days. Control animals received equal volume of normal saline. Behavioral testing in water maze and spontaneous object recognition tasks started on day 14. Levels of interleukin (IL)-1beta and IL-10 were quantified to assess inflammatory state. Also, beta amyloid (Abeta) clearance and Abeta load were measured.
Our results show that:
- 1) aged rats demonstrated significant learning and memory impairment overall compared to younger animals. However, the age-related decline in learning and memory was ameliorated by the supplementation of vitamin D.
No vitamin D effect on learning and memory was seen in the young animals;
- 2) the pro-inflammatory cytokine IL-1beta is significantly increased while the anti-inflammatory cytokine IL-10 is significantly decreased in the aged rats compared to the young animals; but this age-related change in inflammatory state was mitigated by vitamin D supplementation.
No effects of vitamin D were seen on the IL-1beta and IL-10 expression in the young rats;
- 3) vitamin D increased Abeta clearance and decreased amyloid burden in the aged rats
while no significant difference was seen between the young animal groups.
Our data suggest that vitamin D supplementation modulated age-related increase in pro-inflammatory state and amyloid burden. It is possible that these effects of vitamin D mediated the decrease memory impairment seen in the aged rats making it a useful therapeutic option to alleviate the effects of aging on cognitive function.
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