Vitamin D increases Prostaglandins which increases a wide variety of pains – 2018

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See also VitaminDWiki

• Overview Pain and Vitamin D
• Widespread pain, arthritis pain and muscle pain are associated with low vitamin D – meta-analysis March 2018
• https://vitamindwiki.com/Search+Results?hl=en&oe=UTF-8&ie=UTF-8&btnG=Google+Search&googles.x=0&googles.y=0&q=Prostaglandins&domains=vitamindwiki.com&sitesearch=vitamindwiki.comSearch VitaminDWiki for PROSTAGLANDINS 391 items as of April 2018
• Menstrual Pain (PMS) reduced by vitamin D – RCT 2012, 2014, 2016

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Pain - chronic category in VitaminDWiki

Starts with the following

167 items in category Chronic pain

See also

• Overview Pain and Vitamin D
• Percentage of people with pain increased 25 percent in 18 years – Jan 2019
• Pain not reduced by 60,000 IU monthly vitamin D (need 50,000 IU weekly) – RCT Aug 2023
• Overview Fibromyalgia or Chronic Fatigue and vitamin D
• Overview Rheumatoid Arthritis and vitamin D
• Shingles and vitamin D
• Shin splints decrease with vitamin D
• Migraine and Vitamin D
• Headache category 82 items
• "musculoskeletal pain" 490 items as of Aug 2023
• "chronic fatigue" 185 items as of Jan 2017
• Category Back Pain 44 items
• 7 pain studies in VitaminDWiki with KNEE in the title as of Aug 2023 (see below)
• Opioid OR Opiate OR Morphine in the title 10 pages as of June 2021

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Prostaglandins: Definition, Function, and Associated Conditions Self-Hacked Jan 2018

(Nothing about Vitamin D)
Negative Effects of High Prostaglandin Levels
Prostaglandins (PGD2) Can Increase Allergies
High PGE2 Levels May Decrease the Ability to Fight Cancer
High Prostaglandins May Contribute To Inflammation-Related Pain
High Prostaglandins May Cause Migraines and Headaches
High Prostaglandin Levels Cause Menstrual Cramps
High PGE2 Levels May Play a Part in Osteogenesis Imperfecta
High PGE2 Levels Are Linked to Celiac Disease
High PGE2 Levels are Linked to ALS
High PGE2 Levels May Play a Role in Reflux Esophagitis
High PGE2 Levels May Play a Role in Deformity of Nails and Fingers
High PGD2 Levels May Play a Role in Male Pattern Baldness
High PGE2 Levels are Linked to Depression
High PGE2 Levels are Linked to Alzheimer’s Disease
High PGD2 Levels are Linked to Kidney Failure
High PGE2 Levels are Linked to Schizophrenia

Health Benefits of High Prostaglandin Levels
Prostaglandins Protect the Gut and Help Against Ulcers
Prostaglandins Protect the Heart
Prostaglandins Induce Labor
Prostaglandins (PGE2) Can Calm Allergies
PGE2 and PGF2α May Improve Sperm Function

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Low Vitamin D increases Prostaglandins – 2015

Vitamin D and Pain: Vitamin D and Its Role in the Aetiology and Maintenance of Chronic Pain States and Associated Comorbidities
Pain Research and Treatment, Vol 2015, Article ID 904967, 12 pages, http://dx.doi.org/10.1155/2015/904967
Edward A. Shipton and Elspeth E. Shipton
Department of Anaesthesia, University of Otago, Christchurch, Corner of Riccarton and Hagley Avenues, Christchurch 8042, New Zealand

 Download the PDF from VitaminDWiki

The emergence of new data suggests that the benefits of Vitamin D extend beyond healthy bones. This paper looks at Vitamin D and its role in the aetiology and maintenance of chronic pain states and associated comorbidities. The interfaces between pain and Vitamin D and the mechanisms of action of Vitamin D on pain processes are explored. Finally the association between Vitamin D and pain comorbidities such as sleep and depression is investigated. The paper shows that Vitamin D exerts anatomic, hormonal, neurological, and immunological influences on pain manifestation, thereby playing a role in the aetiology and maintenance of chronic pain states and associated comorbidities. More research is necessary to determine whether Vitamin D is useful in the treatment of various pain conditions and whether or not the effect is limited to patients who are deficient in Vitamin D.

Clipped from PDF
4.3.3. Vitamin D and Prostaglandins
Vitamin D influences prostaglandin action by inhibiting COX-2 expression and by stimulating 15-prostaglandin dehydrogenase (15-PGDH) expression [102]. The enzyme 15-PGDH degrades prostaglandins and inhibits prostaglandin-E2 receptor (PGE2) subtypes and prostaglandin-F2 alpha receptor subtypes (Box 2) [102]. Prostaglandins have a direct effect on sensory neurones by lowering the firing threshold, increasing the number of action potentials elicited by a depolarizing stimulus, and enhancing SP and CGRP release [103]. Prostaglandins mediate neuropathic pain in the spinal cord via PGE2 depolarising wide dynamic range neurones [27].

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2,000 IU of vitamin D reduced the prostaglandin cascade in Breast Cancer - 2013

Vitamin D favorably alters the cancer promoting prostaglandin cascade
Anticancer Res. 2013 Sep;33(9):3861-6.
Qin W1, Smith C, Jensen M, Holick MF, Sauter ER.
1 11937 U.S. Hwy 271, Tyler, TX, U.S.A. edward.sauter at uthct.edu.

BACKGROUND:
Preclinical studies suggest that 1,25-dihydroxyvitamin D [1,25(OH)2D] and celecoxib inhibit prostaglandins (PGs) associated with cancer through different mechanisms. We determined if there was synergy in their use.

PATIENTS AND METHODS:
A total of 36 healthy women received daily for one month/menstrual cycle: placebo, 400 international units (IU) vitamin D-3, 2,000 IU vitamin D-3, or 2,000 IU vitamin D-3 plus 400 mg celecoxib. Serum and nipple aspirate fluid (NAF) were analyzed for PGE2 and transforming growth factor (TGF)β1 and -2; serum for 25(OH)D (total, -D-2, -D-3), plasma for celecoxib; and mammary duct RNA for cyclooxygenase (COX)2.

RESULTS:
25(OH)D-3 increased (p<0.01) only in the groups receiving 2,000 IU vitamin D-3. PGE2 decreased in the breast (p=0.01) only after receiving 2,000 IU vitamin D-3; 2,000 IU vitamin D-3 alone was more effective in decreasing PGE2 than 2,000 IU vitamin D-3 plus celecoxib (p=0.018). COX2 expression decreased only in the breasts of women taking 2,000 IU vitamin D-3. Change in circulating 25(OH)D-3 correlated with change in TGFβ2 in the breast.

CONCLUSION: Vitamin D-3 reduces the PG cascade and increases TGFβ2 in a dose-dependent fashion. Adding celecoxib did not provide synergy.

PMID: 24023320