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Vitamin D and Age-Related Macular Degeneration (and 2 AMD meta-analyses) – Oct 2017

Nutrients 2017, 9(10), 1120; doi:10.3390/nu9101120, 13 October 2017
Alfredo Garcia Layana 1,* , Angelo Maria Minnella 2OrcID, Gerhard Garhöfer 3, Tariq Aslam 4,5OrcID, Frank G. Holz 6, Anita Leys 7, Rufino Silva 8,9,10,11OrcID, Cécile Delcourt 12, Eric Souied 13 and Johanna M. Seddon 14,15

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AMD expected to increase about 30% in a decade (adjusted for age)

The estimated prevalence and incidence of late stage age related macular degeneration in the UK
British Journal of Ophthalmology 2012;96:752-756
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13X higher risk of AMD if smoke 20 pack years (i.e. 2 packs a day for 10 years)

  • Incidence of and Risk Factors Associated With Age-Related Macular Degeneration: Four-Year Follow-up From the ALIENOR Study
    May 2018, doi: 10.1001/jamaophthalmol.2018.0504.
     Download the PDF from VitaminDWiki

 Download the PDF from VitaminDWiki

In recent years, the relationship between vitamin D and health has received growing attention from the scientific and medical communities. Vitamin D deficiencies have been repeatedly associated with various acute and chronic diseases, including age-related macular degeneration (AMD). Its active metabolite, 1α,25-dihydoxy vitamin D, acts as a modulator of cell proliferation, differentiation and apoptosis, and cumulative data from experimental and observational studies suggest that relatively a lower vitamin D status could be a potential risk factor for the development of early and/or late AMD. Herein, we made a narrative review of the mechanisms linking a potential role of vitamin D with the current concepts of AMD pathophysiology.

Created by admin. Last Modification: Friday June 14, 2019 21:08:20 GMT-0000 by admin. (Version 21)

Attached files

ID Name Comment Uploaded Size Downloads
11563 AMD 20 pack years.pdf PDF 2018 admin 15 Mar, 2019 00:36 242.05 Kb 119
11556 AMD UK.pdf admin 14 Mar, 2019 22:40 230.27 Kb 100
11555 Late AMD 10 years.jpg admin 14 Mar, 2019 22:39 30.54 Kb 252
9212 AMD.pdf PDF 2017 admin 18 Jan, 2018 10:52 1.13 Mb 211
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