Vitamin D deficiency increases the risk of peripheral neuropathy in Chinese patients with type 2 diabetes.
He, Rui; Hu, Yanyun; Zeng, Hui; Zhao, Jun; Zhao, Jungong; Chai, Yimin; Lu, Fengdi; Liu, Fang; Jia, Weiping
Diabetes/Metabolism: Research & Reviews. AN: 01445403-900000000-99835. online before print, 22 June 2016
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Overview Diabetes and vitamin D contains the following summary
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
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- Sedentary people get less sun / Vitamin D
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Elderly also spend less time outdoors and have more clothes on - All items in category Diabetes and Vitamin D
537 items: both Type 1 and Type 2 Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- 90% less T2 Diabetes in the group having lots of Vitamin D
- Appears that Magnesium helps both Prevention and Treatment
- Many diabetics would be better treated if Gut-Friendly Vitamin D were used
Number of articles in both categories of Diabetes and:
'This list is automatically updated''- Dark Skin
24 ; Intervention 56 ; Meta-analysis 38 ; Obesity 35 ; Pregnancy 44 ; T1 (child) 39 ; Omega-3 11 ; Vitamin D Receptor 24 ; Genetics 12 ; Magnesium 27 Click here to see details Some Diabetes studies
- Type 2 Diabetes treated by Vitamin D (often 50,000 IU weekly) – meta-analysis July 2023
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- Incidence of Type-2 Diabetes increased 3X in 30 years (by the way, Vitamin D helps) – July 2022
- Vitamin d treats Type II Diabetes in many ways (14 article review) - Sept 2021
- T2 Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021
- Diabetes helped somewhat by weekly 50,000 IU of vitamin D (5 ways to improve) – RCT Aug 2021
50 ng of Vitamin D fights Diabetes
- Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
- Diabetes 5X less likely if more than 50 ng of Vitamin D – April 2018
T1 Diabetes
- T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
- Type 1 Diabetes is prevented and treated by Vitamin D – review of 16 studies – Sept 2019
- Type 1 Diabetes prevention with Vitamin D and Omega-3 – Symposium April 2019
Pre-Diabetes
- 4X reduction in prediabetes progressing to T2D if more than 50 ng of vitamin D – RCT March 2023
- Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021
- Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020
Diabetes, Metabolic Syndrome and Magnesium - many studies
Background: Vitamin D deficiency was reported to be associated with diabetic peripheral neuropathy. But the association in Chinese population and the screening value of vitamin D deficiency for diabetic peripheral neuropathy were unknown.Methods: A total of 861 patients with type 2 diabetes were recruited in this cross-sectional study. Vitamin D deficiency was defined as serum circulating 25-hydroxyvitamin D(25(OH)D) level < 20 ng/mL. Peripheral neuropathy was evaluated by neurological symptoms, neurological signs, neurothesiometer and electromyogram.
Results: The patients with diabetic peripheral neuropathy had significantly lower serum 25(OH)D concentration (15.59 +/- 7.68 ng/mL) and higher prevalence of vitamin D deficiency (80%) than patients with signs of diabetic peripheral neuropathy (17.66 +/- 7.50 ng/mL; 64.5%) and non-DPN patients (18.35 +/- 6.60; 61.7%) (all p < 0.01). Spearman's correlation analysis showed that serum circulating 25(OH)D level was closely associated with DPN (r = 0.121) and signs of DPN (r = 0.111) (both p < 0.01). After adjusting for all potential confounders,
VDD was still linked with increased risk of DPN [odds ratio 2.59 (1.48-4.53)] (p < 0.01). Logistical regression analysis further revealed that VDD was an independent risk factor for DPN (beta = 0.88) (p < 0.01). Receiver operating characteristic analysis indicated that serum 25(OH)D < 17.22 ng/mL hinted the signs of DPN and serum 25(OH)D < 16.01 ng/mL predicted the occurrence of DPN (both p < 0.01).
Conclusions: Vitamin D deficiency is an independent risk factor for diabetic peripheral neuropathy and may be a potential biomarker for peripheral neuropathy in Chinese patients with type 2 diabetes.
Copyright (C) 2016 John Wiley & Sons, Ltd. (C) 2016 John Wiley & Sons, Ltd
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