Journal of the Neurological Sciences, Volume 345, Issues 1–2, 15 October 2014, Pages 184–188 DOI: 10.1016/j.jns.2014.07.040
Kristin Elfa, Håkan Askmarkb, Ingela Nygrenb, Anna Rostedt Pungaa
- 16 ng/mL = mean vitamin D level ( ALL < 30 ng/mL)
- Diabetic Neuropathy sometimes can be reversed by vitamin D
- Diabetic neuropathy and low vitamin D, especially in blacks - July 2011
- Diabetics are 2.7 X more likely to get peripheral neuropathy if low vitamin D – meta-analysis Dec 2014
- Diabetic neuropathy least likely if have 30-40 ng of vitamin D – Oct 2015
- Autoimmunity and Optimal Vitamin-D – Stochastic Chemical Dynamic correlation – June 2014
- Impact of vitamin D on immune function: lessons learned from genome-wide analysis – April 2014
- Autoimmune category listing with associated searches
- Overview Diabetes and vitamin D contains the following summary
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on
- All items in category Diabetes and Vitamin D
449 items: both Type 1 and Type 2
Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- Appears that Calcium and Magnesium are needed for both Prevention and Treatment
- which are just some of the vitamin D cofactors
Number of articles in both categories of Diabetes and:
- Dark Skin
22 ; Intervention 49 ; Meta-analysis 28 ; Obesity 26 ; Pregnancy 39 ; T1 (child) 34 ; Omega-3 10 ; Vitamin D Receptor 18 ; Genetics 10 ; Magnesium 18 Click here to see details
- ALL patients with autoimmune peripheral neuropathies (PNP) had vitamin D deficiency.
- Vitamin D levels were lower in patients with PNP than in healthy controls.
- Motor neuron disease patients had comparable vitamin D status to healthy controls.
- We suggest monitoring of vitamin D status in PNP patients.
T cells are important in the immunopathology of immune-mediated peripheral neuropathies (PNP) and activated vitamin D regulates the immune response through increasing the amount of regulatory T cells. An association between vitamin D deficiency and polyneuropathy has been stipulated; hence we assessed whether patients with primary immune-mediated PNP have low vitamin D [25(OH)D] levels.
Plasma levels of 25(OH)D were analyzed in 26 patients with primary immune-mediated PNP, 50 healthy matched blood donors and 24 patients with motor neuron disease (MND). INCAT score was assessed in patients with Guillain–Barré syndrome and chronic inflammatory demyelinating polyneuropathy. ALSFRS-R score was applied to MND patients and the modified Rankin (mRankin) scale compared disability among patient groups.
Mean 25(OH)D value in PNP patients was 40 ± 16 nmol/l, compared to 69 ± 21 nmol/l in healthy blood donors (p < 0.001). MND patients had a higher mean 25(OH)D than PNP patients (59 ± 26 nmol/L; p = 0.006) and comparable levels to healthy blood donors (p = 0.15). Mean 25(OH)D value was not higher in PNP patients with pre-existing vitamin D3 supplementation of 800 IU/day (N = 6; 35 ± 18 nmol/L) than in unsupplemented PNP patients (42 ± 16 nmol). INCAT score ranged from 0 to 10 (mean 3.5) and ALSFRS-R ranged from 11 to 44 (mean 31). mRankin score was more severe in MND patients (mean 3.5) compared to PNP patients (mean 2.1).
All patients with primary immune-mediated PNP were diagnosed with vitamin D deficiency and they had significantly lower 25(OH)D values than healthy control persons and MND patients. We suggest monitoring of vitamin D status in patients with autoimmune PNP, since immune cells are responsive to the ameliorative effects of vitamin D.
Guillain–Barre syndrome; Chronic inflammatory demyelinating polyneuropathy; CIDP; GBS; Vitamin D; AutoimmuneALL autoimmune peripheral neuropathy patients had low vitamin D levels – Oct 2014
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