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Overview Alcohol and Vitamin D

VitaminDWiki references

VitaminDWiki pages containing ALCOHOL in title (24 as of Oct 2021)

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Items found: 25
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Non-alcoholic fatty liver disease: 75 percent of overweight adults and type II diabetics – Aug 2022 16 Jul, 2022
Overview Alcohol and Vitamin D 09 Feb, 2022
Non-Alcoholic Fatty Liver Disease (NAFLD) treated by Vitamin D (20,000 IU weekly after loading dose) – RCT June 2016 05 Oct, 2021
Strong association of non alcoholic fatty liver disease and low vitamin D 28 Oct, 2020
Non-alcoholic Fatty Liver Disease (NAFLD) treated by Vitamin D (in rats this time) – Dec 2019 04 Dec, 2019
Non-alcoholic fatty liver disease and the Vitamin D Receptor – editorial Sept 2019 29 Sep, 2019
Severe Non-Alcoholic fatty liver disease treated by Omega-3 – RCT April 2018 02 Mar, 2019
Non-alcoholic Fatty Liver Disease (4 in 10 seniors) and Vitamin D 26 Aug, 2018
Alcoholic liver cirrhosis treated by 1,000 IU of vitamin D – July 2018 03 Jul, 2018
Getting vitamin D during pregnancy is even more important than avoiding alcohol 07 Feb, 2018
Non-Alcoholic Fatty Liver Disease treated by Omega-3 – three meta-analysis 2016-2017 13 Aug, 2017
Non-Alcoholic Fatty Liver Disease treated by Omega-3 – meta-analysis Oct 2016 13 Aug, 2017
Alcohol while pregnant lowers the vitamin D levels in Winter and Spring – Jan 2017 02 Mar, 2017
Alcoholic liver disease 8X more likely among alcoholics if very low vitamin D – May 2015 29 Nov, 2016
Alcoholics with low vitamin D get more bone fractures -Jan 2011 01 Nov, 2016
Non-alcoholic fatty liver disease associated with much lower vitamin D – Aug 2014 24 Jul, 2016
Non-alcoholic fatty liver disease (NAFLD) reduced somewhat by 50,000 IU vitamin D every 2 weeks – RCT Sept 2014 13 Jul, 2016
Sarcopenia and non-alcoholic fatty liver disease (vitamin D not mentioned) – Sept 2013 07 Mar, 2015
Hepatitis C, non-alcoholic fatty liver disease and vitamin D deficiency – Dec 2014 31 Dec, 2014
Non-alcoholic fatty liver disease associated with low vitamin D – independent of BMI – June 2014 31 Dec, 2014
Cancer incidence in 87 countries is related to food, smoking, alcohol, GDP, and UVB - Jan 2014 08 Jan, 2014
Hypothesis: Low vitamin D is one of the causes of muscle weakness in alcoholics – Dec 2012 31 Jul, 2013
Vitamin D intervention stopped bone loss in those mice getting too much alcohol – Aug 2012 31 Jul, 2013
Alcoholics have osteoporosis – Nov 2010 31 Jul, 2013
Hypothesis lack of vitamin D leads to depression leads to alcohol use 31 Jul, 2013

Chronic Alcohol Consumption reduces Vitamins, such as D - March 2022

Vitamin Supplements as a Nutritional Strategy against Chronic Alcohol Consumption? An Updated Review
"Alcohol use disorder affects about 7.2% of people older than 12 years old"
 Download the PDF from VitaminDWiki

Low Calcium associated with alcohol craving - Nov 2016 (note: low Ca may be due to low Vitamin D)

Association of plasma calcium concentrations with alcohol craving: New data on potential pathways
 Download the PDF from VitaminDWiki
Seems like there are 2 simple solutions: increase Calcium intake and increase Calcium absorption (vitamin D)
Wonder if they have been tried?

Adding Calcium reduced alcohol craving - RCT Feb 2021

850 mg of Caclium DOI: 10.1159/000512763

Pattern and cause of fractures in patients who abuse alcohol: what should we do about it?- 2013

Postgrad Med J. 2013 Jul 26. doi: 10.1136/postgradmedj-2013-131990.
Kelly KN, Kelly C., Liverpool Medical School, Liverpool, UK.

VitaminDWiki: The benefits of Vitamin D include
  1. Increased bone density – offsetting decrease in BMD by alcohol
  2. Decrease chance of falling – increases muscle response vs alcohol decreasing muscle
  3. Might even reduce the need for alcohol – less depression

Alcohol abuse is increasing in the UK and contributes significantly to the rising number of acute hospital admissions.
The effects are increasingly seen among younger people who binge drink.
The effects of excess alcohol on the skeleton have attracted far less attention than those on other organs, but the risk of fractures at important sites, such as the hips and vertebrae, is greatly increased in alcoholics.
This is partly owing to reductions in bone mineral density, but other factors such as an increased rate of falls play an important part.
The contribution of excess alcohol consumption to the risk of fractures is recognised in the widely available fracture assessment tool (FRAX). The mechanisms of fracture in alcohol abusers are complex and involve direct effects on bone cells, and indirect effects, mediated by alcohol, on the endocrine system, pancreas and cytokine system. Poor nutrition, with a reduction in body mass index and vitamin D levels, often contributes significantly. Prevention and treatment of fractures in alcohol abusers has received limited attention, and there are surprisingly few therapeutic trials to guide clinical intervention. Abstinence has been shown to improve markers of bone turnover within 2 months. However, compliance with oral therapeutic agents is often poor, and bisphosphonates may be contraindicated in patients with alcoholic liver disease and varices. The emergence of newer therapeutic options may facilitate controlled prospective studies of the role of parenteral agents in providing protection against both primary and secondary osteoporotic fractures among patients with alcohol abuse.

Putative role of vitamin D in the mechanism of alcoholism and other addictions - a hypothesis Nov 2020

Acta Neuropsychiatrica, 12 Nov 2020, :1-27, DOI: 10.1017/neu.2020.41
Galyuk TM1, Loonen AJM2

OBJECTIVE:Vitamin D deficiency may be a clinical problem in patients with addictions. The authors systematically searched for studies addressing vitamin D and addiction and develop a hypothesis which can direct future research of the possible mechanistic role of vitamin D in the process of addiction.

METHODS:Systematic review of the literature found in PubMed and EMBASE followed by narrative review combined with clinical experiences leading to hypotheses for future research.

RESULTS:Only five articles were identified about a role of vitamin D in the pathophysiology of addiction. Their results are in line with a possible influence of vitamin D in dopaminergic transmission. The cerebral vitamin D status depends upon the functionality of genetic variants of Vitamin D Receptor (VDR) and other involved genes. Routine serum calcidiol levels may not adequately reflect cerebral vitamin D status. Uncertainty exists regarding appropriate calcidiol blood levels and proper dosages for affecting the central nervous system (CNS).

CONCLUSIONS:The putative pathophysiological role of vitamin D in substance abuse has been insufficiently studied which calls to more studies how to measure cerebral vitamin D status in clinical practice. Research is indicated whether vitamin D supplementation should use higher dosages and aim to reach higher calcidiol serum levels. Measuring dopaminergic functioning within the prefrontal cortex as reflected by neuropsychological tests selected as suitable could be a suitable proxy for the cerebral vitamin D status when studying the pharmacogenomics of this functionality in patients.

Drinkers of alcohol 2X more likely to have pain if low vitamin D – Nov 2020

Association Between Serum 25-Hydroxyvitamin D Concentrations and Chronic Pain: Effects of Drinking Habits
J Pain Res. 2020 Nov 19;13:2987-2996. doi: 10.2147/JPR.S277979. eCollection 2020.
Keita Suzuki 1, Hiromasa Tsujiguchi 1 2 3, Sakae Miyagi 3 4, Thao Thi Thu Nguyen 2, Akinori Hara 1 2 3, Haruki Nakamura 2, Yukari Shimizu 5, Koichiro Hayashi 1, Yohei Yamada 1, Phat Minh Nguyen 2, Yuichi Tao 2, Takayuki Kannon 3 6, Atsushi Tajima 3 6, Hiroyuki Nakamura 1 2 3
 Download the PDF from VitaminDWiki

Purpose: Although the explanation for inconsistencies in the reported association between serum 25-hydroxyvitamin D 25(OH)D levels and chronic pain (CP) has not yet been determined, understanding this discrepancy is necessary for the development of vitamin D supplementation as an effective treatment for CP. The aim of this cross-sectional study was to examine the relationship between 25(OH)D concentrations and CP according to drinking habits in Japanese subjects.

Patients and methods: We distributed invitation letters to 2314 individuals older than 40 years in Shika town, a rural area in Japan, and 724 subjects (386 females; mean age: 63.9 ± 10.4 years) were recruited. CP was defined as persistent pain lasting at least 3 months in any part of the body. Serum concentrations of 25(OH)D, a biomarker of the vitamin D status, were measured using a radioimmunoassay. A serum 25(OH)D level <20 ng/mL was defined as serum 25(OH)D deficiency. Drinking habits were assessed using a self-administered questionnaire. There were three choices, "rarely drink", "sometimes" and "everyday". Respondents who answered "rarely drink" were labelled as non-drinkers and the others as drinkers.

Results: The prevalence of CP was 40.6%. A significant interaction between CP and drinking habits on 25(OH)D concentrations was observed (p = 0.098). A one-way analysis of covariance was performed to compare 25(OH)D concentrations between the subjects with and without CP in each drinking group, and the serum 25(OH)D levels of subjects with CP were significantly lower than those without CP among drinkers (p = 0.007).
Alcohol A logistic regression analysis revealed a correlation between serum 25(OH)D deficiency and CP in drinkers after adjustments for several confounding factors (odds ratio: 0.499; 95% confidence interval: 0.268 - 0.927; p = 0.028).

Conclusion: The present results suggest that low serum 25(OH)D concentrations are associated with the development of CP in drinkers.

Google Scholar allintitle:(alcohol "vitamin d") -alcoholic 64 entries as of Nov 2022


  • Vitamin D and alcohol: A review of the current literature - 2017 https://doi.org/10.1016/j.psychres.2016.10.051
    • Not a consistant association
  • Association between Fok I vitamin D receptor gene (VDR) polymorphism and impulsivity in alcohol-dependent patients - 2014 Image

New York Times Overview of Alcohol and Health - Dec 2015 (nothing about vitamin D)

Alcohol’s Effect on Health: What the Science Says

  • Nice review of many studies over the past 25 years. including Randomized Controlled Trials
  • "Moderate consumption of alcohol is generally safe, as long as it doesn't lead to abuse, and may even be healthful for some people"
  • "Synthesizing all this, there seems to be a sizable amount of evidence that moderate alcohol consumption is associated with decreased rates of cardiovascular disease, diabetes and death. It also seems to be associated with increased rates, perhaps to a lesser extent, of some cancers, especially breast cancer, as well as some other diseases or conditions. The gains from improved cardiovascular disease deaths seem to outweigh all of the losses in other diseases combined. The most recent report of the U.S.D.A. Scientific Advisory Panel agrees with that assessment."

Huge variation in average daily alcohol consumption - Washington Post, Dec 2015 (nothing about Vitamin D)

Americans are drinking themselves to death at record rates

Nutrient deficiencies due to Alcoholism- 2005

Psychiatric Implications of Nutritional Deficiencies in Alcoholism
GrassrootsHealth Sept 2021


  • Alcohol and Native Americans Wikipedia
    • 4X higher death rate for directly realted alcohol problems: traffic collisions,liver disease. homicide, suicide, and falls
    • also hearing and vision problems, kidney and bladder problems, pneumonia, tuberculosis, dental problems, and pancreatitis
    • among American Indians and Alaska Natives, the rate of fetal alcohol spectrum disorder is 5.6 per 1,000 live births.
      • ~25X higher than typical

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Created by admin. Last Modification: Thursday November 17, 2022 10:17:15 GMT-0000 by admin. (Version 91)

Attached files

ID Name Comment Uploaded Size Downloads
17239 Chronic Alcohol Consumption.pdf PDF 2022 admin 16 Mar, 2022 13:49 1.30 Mb 326
16342 Alcoholics poor VDR.jpg admin 02 Oct, 2021 18:53 22.70 Kb 1793
16197 Alchol deficiencies.jpg admin 07 Sep, 2021 21:27 26.23 Kb 1830
14773 Alcohol Calcium.jpg admin 24 Dec, 2020 16:07 57.18 Kb 2068
14772 Alcohol and Calcium.pdf admin 24 Dec, 2020 16:00 424.93 Kb 338
14623 Pain and drinking.pdf PDF 2020 admin 27 Nov, 2020 16:16 2.07 Mb 373
6273 Washington Post Alcohol.jpg admin 22 Dec, 2015 21:17 69.84 Kb 2693