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Metabolic Syndrome 3X less likely in college students with enough vitamin D – June 2014

Vitamin D Status and Risk of Metabolic Syndrome among Non-diabetic Young

Clinical Nutrition
Chiao-Yu Huang, Mda, bretthuang at ntu.edu.tw, Hao-Hsiang Chang, MD, MSca, Chia-Wen Lu, MD, MSca, Fen-Yu Tseng, MD, PhDb, Long-Teng Lee, MD, PhDa, Kuo-Chin Huang, MD, PhDa, c, d (Professor)

Background and Aims
Low vitamin D status has been linked to obesity, insulin resistance, and metabolic syndrome. In the present study, we aimed to explore the nature and strength of the relationship between vitamin D and metabolic syndrome among non-diabetic young adults.

This was a campus-based cross-sectional study of 355 non-diabetic young adult graduate students (233 males and 132 females; mean age, 23.5±2.4 years) in Northern Taiwan. We measured and tested the association of serum 25-hydroxyvitamin D levels with metabolic syndrome and cardio-metabolic parameters.

A total of 24(6.8%) recruited young adults had metabolic syndrome. There were decreasing trends of body mass index (BMI), Homeostasis Model of Assessment - Insulin Resistance(HOMA-IR) and prevalence of metabolic syndrome across increasing tertiles of vitamin D levels irrespective of age and sex (P for trend <0.05). Without adjusting for BMI or HOMA-IR, the odds of having metabolic syndrome decreased across increasing tertiles of vitamin D levels (P for trend 0.021). The odds ratio of having metabolic syndrome was 0.26 (95% confidence interval: 0.08-0.85, P =0.025) for the highest vs. the lowest tertile of vitamin D levels. However, further adjustments for BMI and HOMA-IR largely removed the inverse association of vitamin D status with metabolic syndrome and its individual components.

Among non-diabetic young adults, the potential inverse relationship between vitamin D status and metabolic syndrome may be attributable to the conjunctive effects of individual obesity and insulin resistance.

See also VitaminDWiki

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