World J Diabetes. 2015 Jul 10;6(7):896-911.
Strange RC 1, Shipman KE 1, Ramachandran S 1.
1Richard C Strange, Institute for Science and Technology in Medicine, Keele University Medical School, England ST4 6QG, United Kingdom.
Despite the well-recognised role of vitamin D in a wide range of physiological processes, hypovitaminosis is common worldwide (prevalence 30%-50%) presumably arising from inadequate exposure to ultraviolet radiation and insufficient consumption. While generally not at the very low levels associated with rickets, hypovitaminosis D has been implicated in various very different, pathophysiological processes. These include putative effects on the pathogenesis of neoplastic change, inflammatory and demyelinating conditions, cardiovascular disease (CVD) and diabetes. This review focuses on the association between hypovitaminosis D and the metabolic syndrome as well as its component characteristics which are
- central obesity,
- glucose homeostasis,
- insulin resistance,
- hypertension and
- atherogenic dyslipidaemia.
We also consider the effects of hypovitaminosis D on outcomes associated with the metabolic syndrome such as
- diabetes and
- non-alcoholic fatty liver disease.
We structure this review into 3 distinct sections;
- the metabolic syndrome,
- vitamin D biochemistry and the putative association between hypovitaminosis D,
- the metabolic syndrome and cardiovascular risk.
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