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UV (perhaps Nitric Oxide) better than vitamin D at preventing obesity in rats on a high-fat diet – Nov 2014

Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin D in mice fed a high-fat diet.

Diabetes. 2014 Nov;63(11):3759-69. doi: 10.2337/db13-1675.
Geldenhuys S 1, Hart PH 1, Endersby R 1, Jacoby P 1, Feelisch M 2, Weller RB 3, Matthews V 4, Gorman S 5.
1 Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia.
2 Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, U.K.
3 University of Edinburgh, MRC Centre for Inflammation Research, Edinburgh, Scotland.
4 Laboratory for Metabolic Dysfunction, Harry Perkins Institute of Medical Research, Centre for Medical Research, The University of Western Australia, Perth, Western Australia, Australia.
5 Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia shelley.gorman at telethonkids.org.au.

The role of vitamin D in curtailing the development of obesity and comorbidities such as the metabolic syndrome (MetS) and type 2 diabetes has received much attention recently. However, clinical trials have failed to conclusively demonstrate the benefits of vitamin D supplementation. In most studies, serum 25-hydroxyvitamin D [25(OH)D] decreases with increasing BMI above normal weight. These low 25(OH)D levels may also be a proxy for reduced exposure to sunlight-derived ultraviolet radiation (UVR).

Here we investigate whether UVR and/or vitamin D supplementation modifies the development of obesity and type 2 diabetes in a murine model of obesity.
Long-term suberythemal and erythemal UVR significantly suppressed

  • weight gain,
  • glucose intolerance,
  • insulin resistance,
  • nonalcoholic fatty liver disease measures; and
  • serum levels of fasting insulin,
  • glucose, and
  • cholesterol

in C57BL/6 male mice fed a high-fat diet.
However, many of the benefits of UVR were not reproduced by vitamin D supplementation. In further mechanistic studies, skin induction of the UVR-induced mediator nitric oxide (NO) reproduced many of the effects of UVR.
These studies suggest that UVR (sunlight exposure) may be an effective means of suppressing the development of obesity and MetS, through mechanisms that are independent of vitamin D but dependent on other UVR-induced mediators such as NO.

PMID: 25342734


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 Download the PDF from VitaminDWiki.

Supplementary Data online


Vitamin D supplementation = 2,280 IU/kg of feed = an OK amount

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Attached files

ID Name Comment Uploaded Size Downloads
4790 UV Obesity 3C.jpg admin 31 Dec, 2014 14:31 26.84 Kb 521
4789 UV Obesity 3B.jpg admin 31 Dec, 2014 14:30 38.34 Kb 523
4787 UV Obesity 3A.jpg admin 31 Dec, 2014 14:26 45.15 Kb 528
4786 Ultraviolet radiation suppresses obesity and symptoms.pdf PDF 2014 admin 31 Dec, 2014 14:16 1.78 Mb 521
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